The highly conserved codon following the slippery sequence supports -1 frameshift efficiency at the HIV-1 frameshift site. [PDF]
PLoS ONE, 2015 HIV-1 utilises -1 programmed ribosomal frameshifting to translate structural and enzymatic domains in a defined proportion required for replication. A slippery sequence, U UUU UUA, and a stem-loop are well-defined RNA features modulating -1 frameshifting
Suneeth F Mathew +6 more
doaj +1 more source
Predicting ribosomal frameshifting efficiency [PDF]
Physical Biology, 2008 Many retroviruses use -1 ribosomal frameshifting as part of the mechanism in translational control of viral protein synthesis. Quantitative prediction of the efficiency of -1 frameshifting is crucial for understanding the viral gene expression. Here we investigate the free energy landscape for a minimal -1 programmed ribosomal frameshifting machinery ...
Song, Cao, Shi-Jie, Chen
openaire +2 more sources
Investigating the correlation between Xrn1-resistant RNAs and frameshifter pseudoknots
RNA Biology, 2023 Xrn1-resistant RNA structures are multifunctional elements employed by an increasing number of RNA viruses. One of such elements is the coremin motif, discovered in plant virus RNAs, of which the structure has been hypothesized to form a yet unelucidated
Ivar W. Dilweg +3 more
doaj +1 more source
Antisense-induced ribosomal frameshifting [PDF]
Nucleic Acids Research, 2006 Programmed ribosomal frameshifting provides a mechanism to decode information located in two overlapping reading frames by diverting a proportion of translating ribosomes into a second open reading frame (ORF). The result is the production of two proteins: the product of standard translation from ORF1 and an ORF1-ORF2 fusion protein.
Henderson, Clark M. +2 more
openaire +2 more sources
Regulation of programmed ribosomal frameshifting by co-translational refolding RNA hairpins. [PDF]
PLoS ONE, 2013 RNA structures are unwound for decoding. In the process, they can pause the elongating ribosome for regulation. An example is the stimulation of -1 programmed ribosomal frameshifting, leading to 3' direction slippage of the reading-frame during ...
Che-Pei Cho +4 more
doaj +1 more source
A three-stemmed mRNA pseudoknot in the SARS coronavirus frameshift signal. [PDF]
PLoS Biology, 2005 A wide range of RNA viruses use programmed -1 ribosomal frameshifting for the production of viral fusion proteins. Inspection of the overlap regions between ORF1a and ORF1b of the SARS-CoV genome revealed that, similar to all coronaviruses, a programmed -
Ewan P Plant +5 more
doaj +1 more source
Restriction of SARS-CoV-2 replication by targeting programmed -1 ribosomal frameshifting. [PDF]
Proc Natl Acad Sci U S A, 2021 Sun Y +11 more
europepmc +2 more sources
A drug screening toolkit based on the –1 ribosomal frameshifting of SARS-CoV-2
Heliyon, 2020 The –1 ribosomal frameshifting is vital for the translation of the open reading frame (ORF)1b in SARS-CoV-2. The products of ORF1b participate in viral replication. Therefore, changing the frameshift frequency reduces the survival of the virus.
Yanqiong Chen +8 more
doaj +1 more source
Bacterial riboproteogenomics : the era of N-terminal proteoform existence revealed [PDF]
, 2020 With the rapid increase in the number of sequenced prokaryotic genomes, relying on automated gene annotation became a necessity. Multiple lines of evidence, however, suggest that current bacterial genome annotations may contain inconsistencies and are ...
Fijalkowska, Daria +3 more
core +2 more sources
High-throughput interrogation of programmed ribosomal frameshifting in human cells
Nature Communications, 2020 Programmed ribosomal frameshifting—the slippage of the ribosome to an alternative frame — is critical for viral replication and cellular processes.
Martin Mikl, Yitzhak Pilpel, Eran Segal
doaj +1 more source