Results 11 to 20 of about 59,620 (205)

Thermodynamic control of −1 programmed ribosomal frameshifting [PDF]

Nature Communications, 2019
Programmed ribosomal frameshifting (PRF) is an alternative translation strategy that causes controlled slippage of the ribosome along the mRNA, changing the sequence of the synthesized protein.
Lars V. Bock, Neva Caliskan, Natalia Korniy, Frank Peske, Marina V. Rodnina, Helmut Grubmüller   +5 more
doaj   +8 more sources

Evaluating ribosomal frameshifting in CCR5 mRNA decoding. [PDF]

Nature, 2022
Khan YA, Loughran G, Steckelberg AL, Brown K, Kiniry SJ, Stewart H, Baranov PV, Kieft JS, Firth AE, Atkins JF.   +9 more
europepmc   +5 more sources

On programmed ribosomal frameshifting: the alternative proteomes [PDF]

Frontiers in Genetics, 2012
Frameshifting results from two main mechanisms: genomic insertions or deletions (indels) or programmed ribosomal frameshifting. Whereas indels can disrupt normal protein function, programmed ribosomal frameshifting can result in dual-coding genes, each ...
Robin eKetteler
doaj   +3 more sources

Stem loop binding protein promotes SARS-CoV-2 replication via -1 programmed ribosomal frameshifting [PDF]

Signal Transduction and Targeted Therapy
The -1 programmed ribosomal frameshifting (-1 PRF) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for keeping the balance between pp1a and pp1ab polyproteins.
Tanxiu Chen, Ruimin Zhu, Tingfu Du, Hao Yang, Xintian Zhang, Zhixing Wang, Yong Zhang, Wenqi Quan, Bin Yin, Yunpeng Liu, Shuaiyao Lu, Xiaozhong Peng   +11 more
doaj   +2 more sources

Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation [PDF]

Nature Communications, 2021
Translational frameshifting is a mechanism that expands the coding capabilities of mRNA. Here, structures of 70S ribosome complexes with GTPase elongation factor G (EF-G), a +1-frameshifting-prone mRNA and tRNAs reveal the cooperation between the ...
Gabriel Demo, Howard B. Gamper, Anna B. Loveland, Isao Masuda, Christine E. Carbone, Egor Svidritskiy, Ya-Ming Hou, Andrei A. Korostelev   +7 more
doaj   +2 more sources

Identifying Inhibitors of −1 Programmed Ribosomal Frameshifting in a Broad Spectrum of Coronaviruses [PDF]

Viruses, 2022
Recurrent outbreaks of novel zoonotic coronavirus (CoV) diseases in recent years have highlighted the importance of developing therapeutics with broad-spectrum activity against CoVs.
Sneha Munshi, Krishna Neupane, Sandaru M. Ileperuma, Matthew T. J. Halma, Jamie A. Kelly, Clarissa F. Halpern, Jonathan D. Dinman, Sarah Loerch, Michael T. Woodside   +8 more
doaj   +2 more sources

The role of chikungunya virus capsid-viral RNA interactions in programmed ribosomal frameshifting [PDF]

Journal of Virology
Chikungunya virus (CHIKV) is a globally significant arthropod-borne virus that causes outbreaks in tropical and subtropical regions and is rapidly expanding in geographical range.
Jordan A. Farrington, Erin E. Rooney, Richard W. Hardy   +2 more
doaj   +2 more sources

Stimulation of ribosomal frameshifting by antisense LNA

Nucleic Acids Research, 2010
Abstract Programmed ribosomal frameshifting is a translational recoding mechanism commonly used by RNA viruses to express two or more proteins from a single mRNA at a fixed ratio. An essential element in this process is the presence of an RNA secondary structure, such as a pseudoknot or a hairpin, located downstream of the slippery ...
Yu, Chien-Hung, Noteborn, Mathieu H. M., Olsthoorn, René C. L.   +2 more
openaire   +4 more sources

Genome-wide CRISPR screens identify noncanonical translation factor eIF2A as an enhancer of SARS-CoV-2 programmed −1 ribosomal frameshifting

Cell Reports, 2023
Summary: Many positive-strand RNA viruses, including all known coronaviruses, employ programmed −1 ribosomal frameshifting (−1 PRF) to regulate the translation of polycistronic viral RNAs.
Lian-Huan Wei, Yu Sun, Junjie U. Guo
doaj   +2 more sources

Protein-directed ribosomal frameshifting temporally regulates gene expression [PDF]

Nature Communications, 2017
Programmed −1 ribosomal frameshifting (−1 PRF) is a mechanism whereby specific signals within mRNAs direct ribosomes to shift into an alternative reading frame.
Sawsan Napthine, Roger Ling, Leanne K. Finch, Joshua D. Jones, Susanne Bell, Ian Brierley, Andrew E. Firth   +6 more
doaj   +3 more sources