Results 101 to 110 of about 2,174,246 (295)

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Oligonucleotide sequences of specific genes of hamster and ribosomal gene of Leptospira.

, 2020
Oligonucleotide sequences of specific genes of hamster and ribosomal gene of Leptospira.
Josefa B. da Silva (8630073), Naiara M. Alcântara (8630055), Patricia A. E. Abreu (8630067), Gisele O. Souza (8630064), Silvio A. Vasconcellos (4920442), Eneas Carvalho (599871), Paloma L. D. Silva (8630052), Bruna F. Silva (8630058), Paulo L. Ho (364419), Fabiana Lauretti-Ferreira (6183170), Milena A. Akamatsu (3804889), Elizabeth A. L. Martins (8630070), Erika Nakajima (602173), Isabele Grabher (8630061)   +13 more
core   +1 more source

Epigenetics: The Functional Memory of Ribosomal Genes [PDF]

, 2007
The functional importance of Epigenetics arise from DNA sequencing programs that show the need for another code to explain the dynamics of gene expression patterns observed along cell differentiation and organism development. In this context, the study of ribosomal gene silencing is in fact an excellent model to better understand the relationships that
Viegas, Wanda, Silva, Manuela, Neves, Nuno   +2 more
openaire   +2 more sources

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Dissemination of -mediated linezolid resistance among species isolated from a teaching hospital in Beijing, China

Journal of International Medical Research, 2018
Objective The aim of the present study was to report the dissemination of cfr and fexA genes mediated by linezolid resistance among Staphylococcus species.
Jiyong Jian, Liang Chen, Zeqiang Xie, Man Zhang   +3 more
doaj   +1 more source

Characteristics and clustering of human ribosomal protein genes

BMC Genomics, 2006
Background The ribosome is a central player in the translation system, which in mammals consists of four RNA species and 79 ribosomal proteins (RPs). The control mechanisms of gene expression and the functions of RPs are believed to be identical. Most RP
Uechi Tamayo, Washio Takanori, Ishii Kyota, Yoshihama Maki, Kenmochi Naoya, Tomita Masaru   +5 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Epigeneitc silencing of ribosomal RNA genes by Mybbp1a

Journal of Biomedical Science, 2012
Background Transcription of the ribosomal RNA gene repeats by Pol I occurs in the nucleolus and is a fundamental step in ribosome biogenesis and protein translation.
Tan Bertrand, Yang Chang-Ching, Hsieh Chia-Ling, Chou Yin-Hsiang, Zhong Chang-Zheng, Yung Benjamin, Liu Hsuan   +6 more
doaj   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source