Results 81 to 90 of about 2,174,246 (295)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Mitochondrial and nuclear genes suggest that stony corals are monophyletic but most families of stony corals are not (Order Scleractinia, Class Anthozoa, Phylum Cnidaria) [PDF]

, 2008
Modern hard corals (Class Hexacorallia; Order Scleractinia) are widely studied because of their fundamental role in reef building and their superb fossil record extending back to the Triassic.
Carden Wallace, Chen Chaolun Allen, Dai, Chang-Feng, Dai Chang-Feng, Collins Allen, Chuang, Yao-Yang, Fukami Hironobu, Sheppard, Charles (Charles R. C.), Chen, Chaolun Allen, Charles Sheppard, Chuang Yao-Yang, Chen, Chienhsun, Yao-Yang Chuang, Fukami, Hironobu; Chen, Chaolun Allen; Budd, Ann F.; Collins, Allen; Wallace, Carden; Chuang, Yao-Yang; Chen, Chienhsun; Dai, Chang-Feng; Iwao, Kenji; Sheppard, Charles; Knowlton, Nancy; Ahmed, Niyaz, Iwao Kenji, Knowlton Nancy, Budd Ann F., Ann F Budd, Allen Collins, Knowlton, Nancy, Kenji Iwao, Chen Chienhsun, Budd, Ann F., Iwao, Kenji, Hironobu Fukami, Chienhsun Chen, Nancy Knowlton, Chaolun Allen Chen, Chang-Feng Dai, Fukami, Hironobu, Wallace Carden, Sheppard Charles, Collins, Allen, Wallace, Carden C.   +33 more
core   +2 more sources

Genetic Diversity of Rhipicephalus (Boophilus) microplus for a Global Scenario: A Comprehensive Review

Pathogens
Rhipicephalus microplus poses a substantial threat to livestock health and agricultural economies worldwide. Its remarkable adaptability to diverse environments and hosts is a testament to its extensive genetic diversity.
Muthu Sankar, Binod Kumar, Haranahally Vasanthachar Manjunathachar, Balasamudram Chandrasekhar Parthasarathi, Abhijit Nandi, Chemmangat Kunnath Subramanian Neethu, Gaurav Nagar, Srikant Ghosh   +7 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Genes involved in translation of Mycoplasma hyopneumoniae and Mycoplasma synoviae

Genetics and Molecular Biology, 2007
This is a report on the analysis of genes involved in translation of the complete genomes of Mycoplasma hyopneumoniae strain J and 7448 and Mycoplasma synoviae.
Mônica de Oliveira Santos, Nadya da Silva Castro, Maristela Pereira, Célia Maria de Almeida Soares   +3 more
doaj   +1 more source

Reconstruction of ribosomal RNA genes from metagenomic data. [PDF]

PLoS ONE, 2012
Direct sequencing of environmental DNA (metagenomics) has a great potential for describing the 16S rRNA gene diversity of microbial communities. However current approaches using this 16S rRNA gene information to describe community diversity suffer from ...
Lu Fan, Kerensa McElroy, Torsten Thomas
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Transcription of ribosomal RNA genes -- a review

, 2003
This project reviews the transcriptional regulation of ribosomal RNA genes by discussing in detail the structure and the process of transcription of these genes.
Foster, Kara Pauline, DelDotto, Dana Ann
core   +2 more sources