Results 61 to 70 of about 2,174,246 (295)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Cells, 2019 The nucleolus is the largest membrane-less structure in the eukaryotic nucleus. It is involved in the biogenesis of ribosomes, essential macromolecular machines responsible for synthesizing all proteins required by the cell.
Carl C. Correll +2 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Cellular growth is a fundamental process of life and must be precisely controlled in multicellular organisms. Growth is crucially controlled by the number of functional ribosomes available in cells.
Jessica Denise Schwarz +8 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Motif analysis of 24 upregulated ribosomal genes in 23DSI.
, 2015 A. A common motif was found in 11 upregulated ribosomal genes. B. Another motif in other upregulated ribosomal genes. The sequence and site of the two motifs are showed.
Jun Sun (48981) +2 more
core +1 more source
The function of the protein phosphatase Glc7p in transcription termination, RNA processing and transcriptional regulation of ribosomal protein genes [PDF]
, 2007 Gene transcription in general can be subdivided into three main phases: transcription initiation, elongation and termination. The enzyme that accomplishes transcription of protein coding genes, snRNAs and snoRNAs is RNA polymerase II (RNAP II).
Röck, Salome
core +1 more source
Expression Trend of Selected Ribosomal Protein Genes in Nasopharyngeal Carcinoma [PDF]
, 2012 Ribosomal proteins are traditionally associated with protein biosynthesis until recent studies that implicated their extraribosomal functions in human diseases and cancers.
Tiong, Thung-Sing +4 more
core +2 more sources
Архивъ внутренней медицины, 2012 This article shows the special features of the influence of chemotherapy on the indices of the activity of ribosomal genes in vivo. Reduction in the indices of the functional activity of ribosomal genes on 10 chromosomes after the first course of poly ...
Е. В. Трубникова +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Specialized Yeast Ribosomes: A Customized Tool for Selective mRNA Translation [PDF]
, 2013 Evidence is now accumulating that sub-populations of ribosomes - so-called specialized ribosomes - can favour the translation of subsets of mRNAs. Here we use a large collection of diploid yeast strains, each deficient in one or other copy of the set of ...
Klausegger, Alfred +54 more
core +2 more sources