Results 71 to 80 of about 2,174,246 (295)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
European Journal of Entomology, 2015 We have investigated for the first time the chromosomes of Karoophasma biedouwense, a species belonging to the Mantophasmatodea, a recently discovered order of carnivorous insects.
Dorota LACHOWSKA-CIERLIK +3 more
doaj +1 more source
A Decrease in Transcription Capacity Limits Growth Rate upon Translation Inhibition
mSystems, 2020 In bacterial cells, inhibition of ribosomes by sublethal concentrations of antibiotics leads to a decrease in the growth rate despite an increase in ribosome content.
Qing Zhang +5 more
doaj +1 more source
Selection of reference genes for expression analysis using quantitative real-time PCR in the pea aphid, Acyrthosiphon pisum (Harris) (Hemiptera, Aphidiae). [PDF]
PLoS ONE, 2014 To facilitate gene expression study and obtain accurate qRT-PCR analysis, normalization relative to stable expressed housekeeping genes is required. In this study, expression profiles of 11 candidate reference genes, including actin (Actin), elongation ...
Chunxiao Yang +3 more
doaj +1 more source
Trapping Human Ribosomal Protein Genes [PDF]
Genome Research, 1998 The proteins of all cells are assembled by the ribosome, the oldest molecular machine to have evolved in biological systems. Composed, in human cells, of four RNA molecules and 79 proteins, it is unchanged in function and nearly unchanged in structure during the >2 billion years that have passed since the separation of the eubacterial, archaebacterial,
J R, Warner, C R, Nierras
openaire +2 more sources
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Genetics and Molecular Biology, 2009 The location of 18S and 5S rDNA sites was determined in eight species and populations of the fish genus Triportheus by using fluorescent in situ hybridization (FISH). The males and females of all species had 2n = 52 chromosomes and a ZZ/ZW sex chromosome
Débora Diniz +2 more
doaj
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
, 2016 The rank values in ascending order of iPDP and ePDP coefficients of ribosomal and signaling genes (cell-cell communication) genes are compared. The y-axis shows the distributions of rank values. Ribosomal genes (white boxes): their average rank values of
Mark Gerstein (774) +3 more
core +1 more source
Analysis of Nucleolar Protein Dynamics Reveals the Nuclear Degradation of Ribosomal Proteins [PDF]
, 2007 Background: The nucleolus is a subnuclear organelle in which rRNAs are transcribed, processed, and assembled with ribosomal proteins into ribosome subunits.
Lam, Yun Wah +9 more
core +1 more source