Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy
Signal Transduction and Targeted Therapy, 2021 Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the ribosome, are essential for ribosome assembly and function.
Elaine Sanij, Jian Kang, Keefe T Chan
exaly +2 more sources
Eukaryotic viruses encode the ribosomal protein eL40 [PDF]
npj VirusesViruses in the phylum Nucleocytoviricota are large, complex and have an exceptionally diverse metabolic repertoire. Some encode hundreds of products involved in the translation of mRNA into protein, but none was known to encode any of the proteins in ...
Julie Thomy +4 more
doaj +2 more sources
Interaction between the assembly of the ribosomal subunits: Disruption of 40S ribosomal assembly causes accumulation of extra-ribosomal 60S ribosomal protein uL18/L5. [PDF]
PLoS ONE, 2020 Inhibition of the synthesis of an essential ribosomal protein (r-protein) abrogates the assembly of its cognate subunit, while assembly of the other subunit continues.
Nusrat Rahman +2 more
doaj +1 more source
Roles of ribosomal proteins in hematologic disorders and cancers: a review
Emergency and Critical Care Medicine, 2023 . Ribosomes are important organelles for synthesizing proteins in cells. They are composed of ribosomal RNA and more than 80 ribosomal proteins. It is well known that an essential function of ribosomal proteins is to participate in protein translation ...
Jie Wang, Feng Yan
doaj +1 more source
Ribosomal proteins: mutant phenotypes by the numbers and associated gene expression changes [PDF]
Open Biology, 2020 Ribosomal proteins are highly conserved, many universally so among organisms. All ribosomal proteins are structural parts of the same molecular machine, the ribosome.
Michael Polymenis
doaj +1 more source
The characteristic analysis of ribosomal protein l12 in haemaphysalis longicornis (acari: ixodidae) ticks [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022 Ribosomal protein L12 (RpL12) plays an important role in ovarian development and engorgement in vertebrates and invertebrates. However, the functional characteristics of RpL12 in ticks are not clear.
Jin LUO +6 more
doaj +1 more source
mSystems, 2023 Many mutations in genes for ribosomal proteins (r-proteins) and assembly factors cause cell stress and altered cell fate, resulting in congenital diseases collectively called ribosomopathies.
Md Shamsuzzaman +6 more
doaj +1 more source
Identification of Key Genes and Pathways Involved in Circulating Tumor Cells in Colorectal Cancer
Analytical Cellular Pathology, 2022 Background. Characterization of the features associated with circulating tumor cells (CTCs) is one of major interests for predicting clinical outcome of colorectal cancer (CRC) patients.
Ruijun Pan +7 more
doaj +1 more source
Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis
Science, 2020 Metastasis: A matter of translation? Solid tumors shed a small number of cancer cells into the bloodstream, some of which are believed to contribute to metastasis.
R. Ebright +24 more
semanticscholar +1 more source
Evolution of ribosomal protein network architectures
Scientific Reports, 2021 To perform an accurate protein synthesis, ribosomes accomplish complex tasks involving the long-range communication between its functional centres such as the peptidyl transfer centre, the tRNA bindings sites and the peptide exit tunnel.
Youri Timsit +2 more
doaj +1 more source