Results 31 to 40 of about 5,829,574 (377)
The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35
Nature Communications, 2019 The majority of patients with neuroblastoma due to MYCN oncogene amplification and consequent N-Myc oncoprotein over-expression die of the disease. Here our analyses of RNA sequencing data identify the long noncoding RNA lncNB1 as one of the transcripts ...
Pei Y. Liu +34 more
semanticscholar +1 more source
Tumor Biology, 2017 Hepatocellular carcinoma is one of the most prevalent neoplasms and the leading cause of cancer-related mortality worldwide. Mitochondrial ribosomal protein S23 is encoded by a nuclear gene and participates in mitochondrial protein translation ...
Meng Pu +9 more
doaj +1 more source
Dual Inhibition of DKC1 and MEK1/2 Synergistically Restrains the Growth of Colorectal Cancer Cells
Advanced Science, 2021 Colorectal cancer, one of the most commonly diagnosed cancers worldwide, is often accompanied by uncontrolled proliferation of tumor cells. Dyskerin pseudouridine synthase 1 (DKC1), screened using the genome‐wide RNAi strategy, is a previously ...
Guangyan Kan +6 more
doaj +1 more source
Role of ribosomal protein mutations in tumor development (Review)
International Journal of Oncology, 2016 Ribosomes are cellular machines essential for protein synthesis. The biogenesis of ribosomes is a highly complex and energy consuming process that initiates in the nucleolus.
Kaveh M. Goudarzi, M. Lindström
semanticscholar +1 more source
Traffic of interacting ribosomes on mRNA during protein synthesis: effects of chemo-mechanics of individual ribosomes [PDF]
Physical Review E 75, 021902 (2007), 2006 Many {\it ribosomes} simultaneously move on the same messenger RNA (mRNA), each synthesizing separately a copy of the same protein. In contrast to the earlier models, here {\it we develop a ``unified'' theoretical model} that not only incorporates the {\it mutual exclusions} of the interacting ribosomes, but also describes explicitly the mechano ...
arxiv +2 more sources
The ribosomal protein gene RPL5 is a haploinsufficient tumor suppressor in multiple cancer types
OncoTarget, 2017 For many years, defects in the ribosome have been associated to cancer. Recently, somatic mutations and deletions affecting ribosomal protein genes were identified in a few leukemias and solid tumor types.
L. Fancello +4 more
semanticscholar +1 more source
Dissecting the Nuclear Import of the Ribosomal Protein Rps2 (uS5)
Biomolecules, 2023 The ribosome is assembled in a complex process mainly taking place in the nucleus. Consequently, newly synthesized ribosomal proteins have to travel from the cytoplasm into the nucleus, where they are incorporated into nascent ribosomal subunits. In this
Andreas Steiner +9 more
doaj +1 more source
Patterns of ribosomal protein expression specify normal and malignant human cells
Genome Biology, 2016 BackgroundRibosomes are highly conserved molecular machines whose core composition has traditionally been regarded as invariant. However, recent studies have reported intriguing differences in the expression of some ribosomal proteins (RPs) across ...
Joao C. Guimaraes, M. Zavolan
semanticscholar +1 more source
Ancestral Interactions of Ribosomal RNA and Ribosomal Proteins [PDF]
Biophysical Journal, 2017 We have proposed that the ancient ribosome increased in size during early evolution by addition of small folding-competent RNAs. In this Accretion Model, small RNAs and peptides were subsumed onto subunit surfaces, gradually encasing and freezing previously acquired components.
Poorna Roy +3 more
openaire +3 more sources
Biomolecules, 2020 The ribosome is a large ribonucleoprotein complex that synthesizes protein in all living organisms. Ribosome biogenesis is a complex process that requires synchronization of various cellular events, including ribosomal RNA (rRNA) transcription, ribosome ...
Kumudie Jayalath +3 more
doaj +1 more source