Mapping of the saccharomyces cerevisiae oxa1-mitochondrial ribosome interface and identification of MrpL40, a ribosomal protein in close proximity to oxal and critical for oxidative phosphorylation complex assembly [PDF]
, 2009 The Oxa1 protein plays a central role in facilitating the cotranslational insertion of the nascent polypeptide chains into the mitochondrial inner membrane. Mitochondrially encoded proteins are synthesized on matrix-localized ribosomes which are tethered
Jia, Lixia +2 more
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Ribosomal protein RPL26 is the principal target of UFMylation
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Ubiquitin fold modifier 1 (UFM1) is a ubiquitin-like posttranslational modifier that is essential for tissue development in metazoans. Genetic ablation of UFM1 or the genes that encode the enzymes that conjugate UFM1 to protein targets ...
C. P. Walczak +8 more
semanticscholar +1 more source
Frontiers in Genetics, 2022 Introduction: Diamond Blackfan anemia (DBA) is a rare congenital disease characterized by defective maturation of the erythroid progenitors in the bone marrow, for which treatment involves steroids, chronic transfusions, or hematopoietic stem cells ...
Noemy Piantanida +11 more
doaj +1 more source
Isolation of Ribosomal Particles from the Unicellular Cyanobacterium Synechocystis sp. PCC 6803 [PDF]
, 2017 Isolation of ribosomal particles is an essential step in the study of ribosomal components as well as in the analysis of trans-acting factors that interact with the ribosome to regulate protein synthesis and modulate the expression profile of the cell ...
Galmozzi, Carla V. +1 more
core +1 more source
Tumor Biology, 2017 Hepatocellular carcinoma is one of the most prevalent neoplasms and the leading cause of cancer-related mortality worldwide. Mitochondrial ribosomal protein S23 is encoded by a nuclear gene and participates in mitochondrial protein translation ...
Meng Pu +9 more
doaj +1 more source
Analysis of Nucleolar Protein Dynamics Reveals the Nuclear Degradation of Ribosomal Proteins [PDF]
, 2007 SummaryBackgroundThe nucleolus is a subnuclear organelle in which rRNAs are transcribed, processed, and assembled with ribosomal proteins into ribosome subunits.
Abovich +38 more
core +3 more sources
The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35
Nature Communications, 2019 The majority of patients with neuroblastoma due to MYCN oncogene amplification and consequent N-Myc oncoprotein over-expression die of the disease. Here our analyses of RNA sequencing data identify the long noncoding RNA lncNB1 as one of the transcripts ...
Pei Y. Liu +34 more
semanticscholar +1 more source
Dissecting the Nuclear Import of the Ribosomal Protein Rps2 (uS5)
Biomolecules, 2023 The ribosome is assembled in a complex process mainly taking place in the nucleus. Consequently, newly synthesized ribosomal proteins have to travel from the cytoplasm into the nucleus, where they are incorporated into nascent ribosomal subunits. In this
Andreas Steiner +9 more
doaj +1 more source
Adaptive remodeling of the bacterial proteome by specific ribosomal modification regulates Pseudomonas infection and niche colonisation [PDF]
, 2016 Post-transcriptional control of protein abundance is a highly important, underexplored regulatory process by which organisms respond to their environments.
A Brencic +83 more
core +3 more sources
Role of ribosomal protein mutations in tumor development (Review)
International Journal of Oncology, 2016 Ribosomes are cellular machines essential for protein synthesis. The biogenesis of ribosomes is a highly complex and energy consuming process that initiates in the nucleolus.
Kaveh M. Goudarzi, M. Lindström
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