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Molecular mechanisms of ribosomal protein gene coregulation
Genes & Development, 2015 The 137 ribosomal protein genes (RPG) of Saccharomyces provide a model for gene coregulation. Reja et al. examine the positional and functional organization of their regulators (Rap1, Fhl1, Ifh1, Sfp1, and Hmo1), the transcription machinery (TFIIB, TFIID,
Rohit Reja +3 more
semanticscholar +1 more source
pS6K1 as an efficacy marker of GnRH agonist with premenopausal breast cancer
Endocrine Connections, 2019 Estradiol is a key factor for tumorigenesis and prognosis of hormone receptor-positive breast cancer. Adipocytes are one source of estradiol in patients with breast cancer. Recent studies have shown that phosphorylated ribosomal protein S6 kinase-1 plays
Chan Sub Park +8 more
doaj +1 more source
Modelling the effect of ribosome mobility on the rate of protein synthesis [PDF]
Eur. Phys. J. E 44, 19 (2021), 2020 Translation is one of the main steps in the synthesis of proteins. It consists of ribosomes that translate sequences of nucleotides encoded on mRNA into polypeptide sequences of amino acids. Ribosomes bound to mRNA move unidirectionally, while unbound ribosomes diffuse in the cytoplasm.
arxiv +1 more source
Ribosomes and ribosomal RNA as chaperones for folding of proteins
Folding and Design, 1997 Provocative recent reports indicate that the large subunits of either prokaryotic or eukaryotic ribosomes have the capacity to promote refolding of denatured enzymes.Salt-washed Escherichia coli ribosomes are shown to promote refolding of denatured rhodanese.
Gisela Kramer +3 more
openaire +3 more sources
Frontiers in Cell and Developmental Biology, 2022 Cellular growth is a fundamental process of life and must be precisely controlled in multicellular organisms. Growth is crucially controlled by the number of functional ribosomes available in cells.
Jessica Denise Schwarz +8 more
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Gene length as a regulator for ribosome recruitment and protein synthesis: theoretical insights [PDF]
Scientific Reports 7, Article number: 17409 (2017), 2017 Protein synthesis rates are determined, at the translational level, by properties of the transcript's sequence. The efficiency of an mRNA can be tuned by varying the ribosome binding sites controlling the recruitment of the ribosomes, or the codon usage establishing the speed of protein elongation. In this work we propose transcript length as a further
arxiv +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2012 Six DNA regions were evaluated as potential DNA barcodes for Fungi, the second largest kingdom of eukaryotic life, by a multinational, multilaboratory consortium.
Conrad L. Schocha +7 more
semanticscholar +1 more source
Phylogenomics of Prokaryotic Ribosomal Proteins
PLoS ONE, 2011 Archaeal and bacterial ribosomes contain more than 50 proteins, including 34 that are universally conserved in the three domains of cellular life (bacteria, archaea, and eukaryotes). Despite the high sequence conservation, annotation of ribosomal (r-) protein genes is often difficult because of their short lengths and biased sequence composition.
Natalya Yutin +3 more
openaire +7 more sources
BMC Genetics, 2000 Background To date, in eukaryotes, ribosomal protein expression is known to be regulated at the transcriptional and/or translational levels. But other forms of regulation may be possible.
Silar Philippe, Lalucque Hervé
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Scientific Reports, 2022 Food waste is becoming more prevalent, and managing it is one of the most important issues in terms of food safety. In this study, functional proteins and bioactive peptides produced from the enzymatic digestion of black soldier fly (Hermetia illucens L.,
Jiaxin Lu +6 more
doaj +1 more source