Results 51 to 60 of about 6,113,563 (357)
Ribosomal Protein S6 Phosphorylation in the Nervous System: From Regulation to Function
Frontiers in Molecular Neuroscience, 2015 Since the discovery of the phosphorylation of the 40S ribosomal protein S6 (rpS6) about four decades ago, much effort has been made to uncover the molecular mechanisms underlying the regulation of this post-translational modification.
Anne Biever, E. Valjent, E. Puighermanal
semanticscholar +1 more source
G3: Genes, Genomes, Genetics, 2017 Most ribosomal proteins in Saccharomyces cerevisiae are encoded by two paralogs that additively produce the optimal protein level for cell growth. Nonetheless, deleting one paralog of most ribosomal protein gene pairs results in a variety of phenotypes ...
Ryan J. Palumbo +3 more
doaj +1 more source
Dual Inhibition of DKC1 and MEK1/2 Synergistically Restrains the Growth of Colorectal Cancer Cells
Advanced Science, 2021 Colorectal cancer, one of the most commonly diagnosed cancers worldwide, is often accompanied by uncontrolled proliferation of tumor cells. Dyskerin pseudouridine synthase 1 (DKC1), screened using the genome‐wide RNAi strategy, is a previously ...
Guangyan Kan +6 more
doaj +1 more source
Molecular mechanisms of ribosomal protein gene coregulation
Genes & Development, 2015 The 137 ribosomal protein genes (RPG) of Saccharomyces provide a model for gene coregulation. Reja et al. examine the positional and functional organization of their regulators (Rap1, Fhl1, Ifh1, Sfp1, and Hmo1), the transcription machinery (TFIIB, TFIID,
Rohit Reja +3 more
semanticscholar +1 more source
Frontiers in Genetics, 2022 Introduction: Diamond Blackfan anemia (DBA) is a rare congenital disease characterized by defective maturation of the erythroid progenitors in the bone marrow, for which treatment involves steroids, chronic transfusions, or hematopoietic stem cells ...
Noemy Piantanida +11 more
doaj +1 more source
Mapping of the saccharomyces cerevisiae oxa1-mitochondrial ribosome interface and identification of MrpL40, a ribosomal protein in close proximity to oxal and critical for oxidative phosphorylation complex assembly [PDF]
, 2009 The Oxa1 protein plays a central role in facilitating the cotranslational insertion of the nascent polypeptide chains into the mitochondrial inner membrane. Mitochondrially encoded proteins are synthesized on matrix-localized ribosomes which are tethered
Jia, Lixia +2 more
core +3 more sources
Idiosyncratic evolution of conserved eukaryote proteins that are similar in sequence to archaeal or bacterial proteins [PDF]
, 2008 Sequence comparisons have been made between the proteins of 571 prokaryote species including 46 archaea and 525 bacteria and the set of human proteins.
Roy J. Britten
core +2 more sources
Frontiers in Cell and Developmental Biology, 2021 Triple-negative breast cancer (TNBC) is known to have a poor prognosis and limited treatment options. The lack of targeted therapies and poor prognosis of patients with TNBC have made it urgent to discover novel critical diagnosis and therapeutic targets
Weipeng Zhao +7 more
doaj +1 more source
Gastroenterology, 2014 Little is known about the genetic factors that contribute to familial colorectal cancer type X (FCCX), characterized by hereditary nonpolyposis colorectal carcinoma with no mismatch repair defects.
T. Nieminen +12 more
semanticscholar +1 more source
SARS-CoV-2 Nsp1 binds ribosomal mRNA channel to inhibit translation
bioRxiv, 2020 The non-structural protein 1 (Nsp1), also referred to as the host shutoff factor, is the first viral protein that is synthesized in SARS-CoV-2 infected human cells to suppress host innate immune functions1,2.
K. Schubert +9 more
semanticscholar +1 more source