Results 71 to 80 of about 5,829,574 (377)
eLife, 2023 Ribosomal protein (Rp) gene haploinsufficiency can result in Diamond-Blackfan Anemia (DBA), characterized by defective erythropoiesis and skeletal defects.
Virginia Folgado-Marco +4 more
doaj +1 more source
TRF2, but not TBP, mediates the transcription of ribosomal protein genes
Genes & Development, 2014 The ribosome is considered to be the most important molecular machine in the cell. Eukaryotes have two specialized transcription systems—the RNA polymerase I and III systems—for the synthesis of rRNAs and tRNAs. Wang et al.
Yuan-Liang Wang +6 more
semanticscholar +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Survey and multigene characterization of stolbur phytoplasmas on various plant species in Serbia
Phytopathologia Mediterranea, 2013 Stolbur phytoplasmas were detected in 116 out of more than 200 samples from nine plant species col- lected in 2009‒2010 in Serbia. Phytoplasmas were detected and identified by restriction fragment length polymor- phism (RFLP) analysis of polymerase chain
Jelena MITROVIĆ +2 more
doaj +1 more source
Insects, 2022 Due to a lack of effective internal references, studies on functional genes in Phthorimaea operculella, a serious Lepidopteran pest attacking potatoes worldwide, have been greatly limited. To select suitable endogenous controls, ten housekeeping genes of
Chen-Hui Shen +6 more
doaj +1 more source
Stochastic theory of protein synthesis and polysome: ribosome profile on a single mRNA transcript [PDF]
Journal of Theoretical Biology, vol.289, 36-46 (2011), 2011 The process of polymerizing a protein by a ribosome, using a messenger RNA (mRNA) as the corresponding template, is called {\it translation}. Ribosome may be regarded as a molecular motor for which the mRNA template serves also as the track. Often several ribosomes may translate the same (mRNA) simultaneously.
arxiv +1 more source
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source
PLoS ONE, 2015 Quantitative real-time PCR (qRT-PCR) is a powerful technique to quantify gene expression. To standardize gene expression studies and obtain more accurate qRT-PCR analysis, normalization relative to consistently expressed housekeeping genes (HKGs) is ...
Chunxiao Yang +3 more
doaj +1 more source
Ribosomal Protein L10: From Function to Dysfunction
Cells, 2020 Eukaryotic cytoplasmic ribosomes are highly structured macromolecular complexes made up of four different ribosomal RNAs (rRNAs) and 80 ribosomal proteins (RPs), which play a central role in the decoding of genetic code for the synthesis of new proteins.
Daniela Pollutri, Marianna Penzo
doaj +1 more source
Molecular Oncology, EarlyView.The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu +3 more
wiley +1 more source