Results 81 to 90 of about 6,159,973 (405)

Synchronizing Nuclear Import of Ribosomal Proteins with Ribosome Assembly [PDF]

Science, 2012
Symportin Synchrony Ribosomes, the macromolecular machines responsible for protein synthesis, function in the cytoplasm but are assembled in the nucleus. Ribosomal proteins must be imported into the nucleus, but how this is coordinated with assembly is unclear. Kressler et al.
Dagmar Pratte, Irmgard Sinning, Yutaka Ogawa, Dieter Kressler, Dieter Kressler, Bettina Bradatsch, Goran Stjepanovic, Daniela Strauß, Jun Katahira, Yoshihiro Yoneda, Gert Bange, Stefan Amlacher, Ed Hurt   +12 more
openaire   +3 more sources

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Protection against High-Fat-Diet-Induced Obesity in MDM2C305F Mice Due to Reduced p53 Activity and Enhanced Energy Expenditure

Cell Reports, 2017
The RPL11-MDM2 interaction constitutes a p53 signaling pathway activated by deregulated ribosomal biosynthesis in response to stress. Mice bearing an MDM2C305F mutation that disrupts RPL11-MDM2 binding were analyzed on a high-fat diet (HFD).
Shijie Liu, Tae-Hyung Kim, Derek A. Franklin, Yanping Zhang   +3 more
doaj   +1 more source

N-TERMINAL PROCESSING OF RIBOSOMAL PROTEIN L27 IN STAPHYLOCOCCUS AUREUS [PDF]

, 2012
The bacterial ribosome is essential to cell growth yet little is known about how its proteins attain their mature structures. Recent studies indicate that certain Staphlyococcus aureus bacteriophage protein sequences contain specific sites that may be ...
Caufield, J. Harry
core   +1 more source

The replicative lifespan-extending deletion of SGF73 results in altered ribosomal gene expression in yeast. [PDF]

, 2017
Sgf73, a core component of SAGA, is the yeast orthologue of ataxin-7, which undergoes CAG-polyglutamine repeat expansion leading to the human neurodegenerative disease spinocerebellar ataxia type 7 (SCA7).
Garza, Renee M, Kennedy, Brian K, La Spada, Albert R, Mason, Amanda G, McCormick, Mark A, Patel, Bhumil, Pillus, Lorraine   +6 more
core   +2 more sources

TRF2, but not TBP, mediates the transcription of ribosomal protein genes

Genes & Development, 2014
The ribosome is considered to be the most important molecular machine in the cell. Eukaryotes have two specialized transcription systems—the RNA polymerase I and III systems—for the synthesis of rRNAs and tRNAs. Wang et al.
Yuan-Liang Wang, Sascha H. C. Duttke, Kai Chen, Jeff Johnston, G. Kassavetis, J. Zeitlinger, J. T. Kadonaga   +6 more
semanticscholar   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Liver cancer cells with nuclear MET overexpression release translation regulatory protein‐enriched extracellular vesicles exhibit metastasis promoting activity

Journal of Extracellular Biology, 2022
MET receptor tyrosine kinase is a cell surface receptor that plays important role in embryonic development and tissue regeneration. Aberrant MET activation has been widely reported in different human cancers, making MET an attractive therapeutic target ...
Sze Keong Tey, Samuel Wan Ki Wong, Cherlie Lot Sum Yeung, Jason Ying Ki Li, Xiaowen Mao, Clive Yik Sham Chung, Judy Wai Ping Yam   +6 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

pS6K1 as an efficacy marker of GnRH agonist with premenopausal breast cancer

Endocrine Connections, 2019
Estradiol is a key factor for tumorigenesis and prognosis of hormone receptor-positive breast cancer. Adipocytes are one source of estradiol in patients with breast cancer. Recent studies have shown that phosphorylated ribosomal protein S6 kinase-1 plays
Chan Sub Park, Jihye Choi, Min-Ki Seong, Sung-Eun Hong, Jae-Sung Kim, In-Chul Park, Hyesil Seol, Woo Chul Noh, Hyun-Ah Kim   +8 more
doaj   +1 more source