Results 141 to 150 of about 6,124,063 (361)

Gentamicin‐Loaded Carbonate Apatite with Dual Antibacterial and Osteogenic Functions for Combating Surgical Site Infections

Advanced Healthcare Materials, EarlyView.
A bone substitute with gentamicin physically precipitated onto the surface of carbonate apatite exhibits prompt drug release, high bactericidal activity, and osteogenic capacity. Efficient antibacterial activity mitigates early postoperative neutrophil accumulation, the status of which may serve as a potential parameter for evaluating the antibacterial
Linghao Xiao, Gabriela Laranjeira Abe, Jun‐Ichi Sasaki, Haruaki Kitagawa, Ririko Tsuboi, Tomoki Kohno, Satoshi Imazato   +6 more
wiley   +1 more source

The multifaceted roles of ribosomal P complex in cancer

World Journal of Surgical Oncology
The ribosomal P complex, a flexible lateral stalk structure of the ribosomal large subunit, consists of the RPLP0, RPLP1, and RPLP2 proteins, and is essential for the elongation phase of protein biosynthesis.
Bokang Yan, Jiaxing Guo, Weiwei Lai, Yuanbing Chen, Zuli Wang, Yuanhao Peng, Shi Chang   +6 more
doaj   +1 more source

Ribosome biogenesis: A central player in liver diseases

Genes and Diseases
Ribosome biogenesis is a multi-step process that initiates within the nucleolus, terminates in the cytoplasm, and determines the rate of protein synthesis. Ribosome biogenesis is essential for maintaining liver function.
Wei Luo, Jing Zhou, Yongmin Yan, Xuezhong Xu   +3 more
doaj   +1 more source

Ribosomal protein database of Carnobacterium maltaromaticum LMA 28

, 2021
Wenfa Ng
openalex   +1 more source

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons

Cell Reports, 2019
Summary: Ribosome assembly occurs mainly in the nucleolus, yet recent studies have revealed robust enrichment and translation of mRNAs encoding many ribosomal proteins (RPs) in axons, far away from neuronal cell bodies.
Toshiaki Shigeoka, Max Koppers, Hovy Ho-Wai Wong, Julie Qiaojin Lin, Roberta Cagnetta, Asha Dwivedy, Janaina de Freitas Nascimento, Francesca W. van Tartwijk, Florian Ströhl, Jean-Michel Cioni, Julia Schaeffer, Mark Carrington, Clemens F. Kaminski, Hosung Jung, William A. Harris, Christine E. Holt   +15 more
doaj   +1 more source

Nonessential Plastid-Encoded Ribosomal Proteins in Tobacco: A Developmental Role for Plastid Translation and Implications for Reductive Genome Evolution[W][OA]

The Plant Cell, 2011
Of seven plastid genome-encoded ribosomal proteins analyzed by reverse genetics in tobacco (Nicotiana tabacum), two were found to be nonessential: S15 and L36.
Tobias Fleischmann, Lars B. Scharff, Sibah Alkatib, Sebastian Hasdorf, M. Schöttler, R. Bock   +5 more
semanticscholar   +1 more source

DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.
Dharini Srinivasan, Elodie Roger, Lukas Perkhofer, Eleni Zimmer, Thomas F.E. Barth, Julia P. Mosler, Anna Härle, Stephanie E. Weissinger, Nadine T. Gaisa, Peter Möller, Nico Fischer, Chantal Allgöwer, J.‐Matthias Löhr, Dirk Grimm, Thomas Seufferlein, Stefan Liebau, Ninel Azoitei, Michael K. Melzer, Frank Arnold, Johann Gout, Alexander Kleger   +20 more
wiley   +1 more source

Differential Phosphorylation of Ribosomal Proteins in Arabidopsis thaliana Plants during Day and Night

PLoS ONE, 2011
Protein synthesis in plants is characterized by increase in the translation rates for numerous proteins and central metabolic enzymes during the day phase of the photoperiod. The detailed molecular mechanisms of this diurnal regulation are unknown, while
M. Turkina, Hanna Klang Årstrand, A. Vener   +2 more
semanticscholar   +1 more source

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source