Results 201 to 210 of about 6,124,063 (361)

Clinofibrate Disrupts the SNORA80B/YTHDC1‐Driven M6A Modification to Suppress Cholesterol Metabolism and Cisplatin Resistance in ESCC

Advanced Science, EarlyView.
This study uncovers a non‐canonical role of SNORA80B in ESCC, showing it mediates AR‐driven metabolic reprogramming via N⁶‐methyladenosine (m6A) methylation. By binding YTHDC1, SNORA80B stabilizes cholesterol‐metabolic enzyme mRNAs and promotes tumor progression. The FDA‐approved drug clinofibrate inhibits SNORA80B by disrupting cholesterol homeostasis,
Hongyu Yuan, Ge Ge, LiQiu Liu, Sijun Hu, Miaomiao Tian, Yongzhan Nie, Zitong Zhao, Yongmei Song   +7 more
wiley   +1 more source

Therapeutic Reprogramming of Glioblastoma Phenotypic States Using Multifunctional Heparin Nanoparticles

Advanced Science, EarlyView.
This study presents heparin‐derived nanoparticles (HP‐NPs) as a novel precision medicine platform that combines therapeutic and delivery functions. HP‐NPs target drug‐resistant glioblastoma stem cells, reprogramming them into a drug‐sensitive phenotype and significantly reducing tumor progression.
Vadim Le Joncour, Austin D. Evans, Camilla Karoliina Bergström, Vignesh Kumar Rangasami, Sumanta Samanta, Nithiyanandan Krishnan, Yuji Teramura, Bo Nilsson, Patricia Hedenqvist, Elin Manell, Jons Hilborn, Marianne‐Jensen Waern, Oommen P. Varghese, Pirjo Laakkonen, Oommen P. Oommen   +14 more
wiley   +1 more source

Unbalanced regulation of the ribosomal 5 S RNA-binding protein in Saccharomyces cerevisiae expressing mutant 5 S rRNAs.

, 1992
B Tang, Ross N. Nazar
openalex   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Mutation in theDrosophila gene encoding ribosomal protein S21 causes tissue overgrowth of the hematopoietic organs

, 1995
Daniela Herrmann, István Török, Gabriella Tick, István Kiss, Bernand M. Mechler   +4 more
openalex   +2 more sources

RiboMicrobe: An Integrated Translatome Atlas for Microorganism

Advanced Science, EarlyView.
RiboMicrobe is a comprehensive database for Ribo‐seq data from prokaryotes, featuring 891 Ribo‐seq, 369 RNA‐seq, and 62 proteome datasets from 38 species. The database not only provides various data visualization results but also includes two sORF prediction models and a suit of bioinformatics tools for comparative analysis, facilitating easy access ...
Yingshun Zhou, Jinjing Luo, Xiaoqiang Lang, Yuli Gan, Guoxian Liu, Yuling Cui, Fazhi Li, Weicong Zhu, Bing Chen, Yuanyuan Dong, Yinglin Wu, Yi Cao, Qi Liu   +12 more
wiley   +1 more source

Organization and expression of mitochondrial genes for ribosomal proteins and NADH dehydrogenase subunits from a liverwort, Marchantia polymorpha

, 1995
美保 竹村
openalex   +2 more sources

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome

Advanced Science, EarlyView.
This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha, Kyle L. MacQuarrie, Marcelo Carignano, Cody L. Dunton, Ruyi Gong, Joe Ibarra, Lucas M. Carter, Wing Shun Li, Rikkert Nap, Parambir S. Dulai, Igal Szleifer, Vadim Backman   +11 more
wiley   +1 more source

The Central Role of Ribosomal Proteins in p53 Regulation. [PDF]

Cancers (Basel)
Lindström MS.
europepmc   +1 more source

Adaptive preservation of orphan ribosomal proteins in chaperone-dispersed condensates. [PDF]

Nat Cell Biol, 2023
Ali A, Garde R, Schaffer OC, Bard JAM, Husain K, Kik SK, Davis KA, Luengo-Woods S, Igarashi MG, Drummond DA, Squires AH, Pincus D.   +11 more
europepmc   +1 more source