Results 221 to 230 of about 6,124,063 (361)

RNA-binding motif protein 10 inactivates c-Myc by partnering with ribosomal proteins uL18 and uL5. [PDF]

open access: yesProc Natl Acad Sci U S A, 2023
Lee H   +13 more
europepmc   +1 more source

Type I Interferon Pathway Activation Disrupts Monocyte Maturation and Enhances Immune Evasion in Multiple Myeloma

open access: yesAdvanced Science, EarlyView.
This study shows that monocytes in multiple myeloma display an excessive interferon response, leading to transcriptional reprogramming and altered differentiation. Using single‐cell sequencing, coculture experiments, and patient samples before and after therapy, the authors demonstrate that induction treatment reduces this interferon response ...
Jian Cui   +18 more
wiley   +1 more source

Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome. [PDF]

open access: yesElife
Nielsen T   +20 more
europepmc   +1 more source

Aloe‐Emodin Targeting FOXC2 Disrupts NETs Formation and EMT‐Driven Postoperative Peritoneal Adhesion Through TGF‐β1‐Smad2/3 Pathway

open access: yesAdvanced Science, EarlyView.
Forkhead box protein C2 (FOXC2) is highlighted as a pivotal effector in postoperative peritoneal adhesion (PPA) formation. Mechanically, FOXC2 mediates NETs‐induced EMT alterations through the TGF‐β1‐Smad2/3 pathway. Aloe‐emodin (AE) ameliorates FOXC2‐driven fibrosis by blocking NETs formation and EMT changes through this pathway.
Lili Yang   +10 more
wiley   +1 more source

The influence of ribosomal proteins on the action of ribosome-inactivating proteins [PDF]

open access: yes
Ribosome-inactivating proteins (RIPs) are produced by many plants and inhibit ribosome function through an N-glycosidase activity that removes a single adenine residue from a universally-conserved stem-loop structure close to the 3' end of the large subunit rRNA.
openaire  

Development of Endogenous Protein Probes for Characterizing Surface Proteins and Cellular Interactors of Extracellular Vesicles

open access: yesAdvanced Science, EarlyView.
The proximity labeling enzyme APEX2 is displayed on extracellular vesicle (EV) surfaces via genetic fusion with EV‐sorting scaffolds, enabling in situ biotinylation of native surface proteins, adsorbed corona components, and interacting cellular proteins.
Wenyi Zheng   +5 more
wiley   +1 more source

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