Results 21 to 30 of about 1,900,800 (291)

Analysis of Nucleolar Protein Dynamics Reveals the Nuclear Degradation of Ribosomal Proteins [PDF]

, 2007
Background: The nucleolus is a subnuclear organelle in which rRNAs are transcribed, processed, and assembled with ribosomal proteins into ribosome subunits.
Lamond, Angus I., Lam, Yun Wah, Andersen, J.S., Mann, M., Lamond, Angus I, Andersen, Jens S., Andersen, J., Lamond, Angus I.; id_orcid, Lamond, A.I., Mann, Matthias, Lam, Y.W., Lamond, A., Andersen, Jens S; id_orcid, Lam, Y.   +13 more
core   +1 more source

Role of the RNA-binding protein ZC3H41 in the regulation of ribosomal protein messenger RNAs in trypanosomes

Parasites & Vectors, 2023
Background Trypanosomes are single-celled eukaryotes that rely heavily on post-transcriptional mechanisms to regulate gene expression. RNA-binding proteins play essential roles in regulating the fate, abundance and translation of messenger RNAs (mRNAs ...
Gloria Ceballos-Pérez, Miriam Rico-Jiménez, Claudia Gómez-Liñán, Antonio M. Estévez   +3 more
doaj   +1 more source

Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan [PDF]

, 2015
Several pathways modulating longevity and stress resistance converge on translation by targeting ribosomal proteins or initiation factors, but whether this involves modifications of ribosomal RNA is unclear.
Wilson, Iain B H, Mohr, Thomas, Mattanovich, Diethard, Breitenbach, Michael, Linder, Angela, Karl, Thomas, Amring, Manuela, Wilson, Iain B.H., Grillari-Voglauer, Regina, Polacek, Norbert, Angerer, Tina B., Rinnerthaler, Mark, Angerer, Tina B, Pircher, Andreas, Schosserer, Markus, Grillari, Johannes, Sharma, Sunny, Minois, Nadege, Breitenbach-Koller, Hannelore, Entian, Karl-Dieter, Kriegner, Albert, Steiger, Matthias, Breitenbach-Koller, Lore, Pfeifenberger, Sigrid, Dellago, Hanna, Calle-Perez, Alfonso, Brandl, Clemens, Weinhäusel, Andreas, Harreither, Eva, Kos, Martin, Sonntagbauer, Markus, Gerstl, Matthias Peter   +31 more
core   +2 more sources

The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins

Cell Reports, 2023
Summary: In mammals, about 99% of mitochondrial proteins are synthesized in the cytosol as precursors that are subsequently imported into the organelle. The mitochondrial health and functions rely on an accurate quality control of these imported proteins.
Julie Lavie, Claude Lalou, Walid Mahfouf, Jean-William Dupuy, Aurélie Lacaule, Agata Ars Cywinska, Didier Lacombe, Anne-Marie Duchêne, Anne-Aurélie Raymond, Hamid Reza Rezvani, Richard Patryk Ngondo, Giovanni Bénard   +11 more
doaj   +1 more source

The small-subunit processome is a ribosome assembly intermediate [PDF]

, 2004
The small-subunit (SSU) processome is a large ribonucleoprotein required for the biogenesis of the 18S rRNA and likely corresponds to the terminal knobs visualized by electron microscopy on the 5' end of nascent rRNAs.
Granneman, Sander; id_orcid, Baserga, Susan J, Gallagher, Jennifer E G, Mitchell, Brianna M, Bernstein, Kara A   +4 more
core   +1 more source

Cotranslational Folding of Proteins on the Ribosome [PDF]

Biomolecules, 2020
Many proteins in the cell fold cotranslationally within the restricted space of the polypeptide exit tunnel or at the surface of the ribosome. A growing body of evidence suggests that the ribosome can alter the folding trajectory in many different ways. In this review, we summarize the recent examples of how translation affects folding of single-domain,
Marija Liutkute, Ekaterina Samatova, Marina V. Rodnina   +2 more
openaire   +5 more sources

Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors [PDF]

, 2014
Ribosome biogenesis is a key process for maintaining protein synthetic capacity in dividing or growing cells, and requires coordinated production of ribosomal proteins and ribosomal RNA (rRNA), including the processing of the latter.
Proud, C., Taylor, Peter M., Liu, R., Iadevaia, Valentina, Averous, Julien, Liu, R, Proud, Christopher G., Proud, CG, Taylor, P., Zhang, Z., Taylor, PM, Zhang, Z, Liu, Rui, Iadevaia, V, Zhang, Ze, Averous, J., Averous, J, Iadevaia, V.   +17 more
core   +1 more source

An HflX-type GTPase from Sulfolobus solfataricus binds to the 50S ribosomal subunit in all nucleotide-bound states [PDF]

, 2011
HflX GTPases are found in all three domains of life, Bacteria, Archaea, and Eukaryotes. HflX from Escherichia coli has been shown to bind to the 50S ribosomal subunit in a nucleotide-dependent manner and this interaction strongly stimulates its GTPase ...
Fabian Blombach, J. Van Der Oost, Daan C. Swarts, John van der Oost, Londei, P., LONDEI, Paola, Christodoulou, John, John Christodoulou, Dario Benelli, D. c. Swarts, Lisa D. Cabrita, Launay, H., BENELLI, DARIO, H. Launay, Benelli, D., L. d. Cabrita, Violeta Zorraquino, Zorraquino, V., Cabrita, L.D., V. Zorraquino, Oost, J., van der, F. Blombach, J. Christodoulou, Helene Launay, Paola Londei, van der Oost, J., Blombach, F., Swarts, D.C.   +27 more
core   +1 more source

The human RPS4 paralogue on Yq11.223 encodes a structurally conserved ribosomal protein and is preferentially expressed during spermatogenesis. [PDF]

, 2010
BACKGROUND: The Y chromosome of mammals is particularly prone to accumulate genes related to male fertility. However, the high rate of molecular evolution on this chromosome predicts reduced power to the across-species comparative approach in identifying
Ricardo N Miguel, Nabeel A Affara, Ellis, Peter J.I., Lopes, Alexandra M., Sargent, Carole A., Alexandra M Lopes, Amorim, António, Antonio Amorim, Carole A Sargent, Peter J Ellis, Miguel, Ricardo N., Affara, Nabeel A.   +11 more
core   +7 more sources

Principles of cellular resource allocation revealed by condition-dependent proteome profiling

eLife, 2017
Growing cells coordinate protein translation with metabolic rates. Central to this coordination is ribosome production. Ribosomes drive cell growth, but translation of ribosomal proteins competes with production of non-ribosomal proteins.
Eyal Metzl-Raz, Moshe Kafri, Gilad Yaakov, Ilya Soifer, Yonat Gurvich, Naama Barkai   +5 more
doaj   +1 more source