Results 51 to 60 of about 1,994,746 (285)
Placeholder factors in ribosome biogenesis: please, pave my way
Microbial Cell, 2017 The synthesis of cytoplasmic eukaryotic ribosomes is an extraordinarily energy-demanding cellular activity that occurs progressively from the nucleolus to the cytoplasm.
Francisco J. Espinar-Marchena +2 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
rRNA maturation in yeast cells depleted of large ribosomal subunit proteins. [PDF]
PLoS ONE, 2009 The structural constituents of the large eukaryotic ribosomal subunit are 3 ribosomal RNAs, namely the 25S, 5.8S and 5S rRNA and about 46 ribosomal proteins (r-proteins).
Gisela Pöll +7 more
doaj +1 more source
Ribosomal protein paralogues in ribosome specialization
Philosophical Transactions of the Royal Society B: Biological SciencesRibosomes are macromolecular complexes responsible for protein synthesis, comprising ribosomal proteins (RPs) and ribosomal RNA. While most RPs are present as single copies in higher eukaryotes, a handful of them have paralogues that emerged through duplication events.
Ivan Milenkovic, Eva Maria Novoa
openaire +3 more sources
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Differential modules of ribosomal proteins in yeast.
, 2016 Hierarchical clustering of Pearson correlations among ribosomal proteins for (B) normalized growth from single deletion of ribosomal proteins in 26 environments, (C) double deletion interactions with 121 genes.
Himanshu Sinha (61487) +5 more
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
The Evolution of the Ribosome and the Genetic Code
Life, 2014 The evolution of the genetic code is mapped out starting with the aminoacyl tRNA-synthetases and their interaction with the operational code in the tRNA acceptor arm.
Hyman Hartman, Temple F. Smith
doaj +1 more source
Extraribosomal Functions of Cytosolic Ribosomal Proteins in Plants
Frontiers in Plant Science, 2021 Ribosomes are basic translational machines in all living cells. The plant cytosolic ribosome is composed of four rRNAs and approximately 81 ribosomal proteins (RPs). In addition to the fundamental functions of RPs in the messenger RNA decoding process as
Wei Xiong +4 more
doaj +1 more source
Ribosomes and ribosomal RNA as chaperones for folding of proteins
Folding and Design, 1997 Provocative recent reports indicate that the large subunits of either prokaryotic or eukaryotic ribosomes have the capacity to promote refolding of denatured enzymes.Salt-washed Escherichia coli ribosomes are shown to promote refolding of denatured rhodanese.
Kudlicki, Wieslaw +3 more
openaire +2 more sources