Results 161 to 170 of about 1,110,020 (298)

A microRNA generated via lysosomal processing of ribosomal RNA suppresses proinflammatory responses. [PDF]

Life Sci Alliance
Michael D, Feldmesser E, Rajan KS, Lubelsky Y, Bashan A, Damalas A, Ben Zvi S, Friedberg A, Eitan N, Erez S, Yonath A, Ulitsky I, Oren M.   +12 more
europepmc   +1 more source

Determination of Gene‐Level Fitness Contributions Across the Mucin‐Utilization Network of Bacteroides thetaiotaomicron

Advanced Science, EarlyView.
Genome‐wide CRISPRi and RNA‐seq resolve how B. thetaiotaomicron converts host mucosal glycans into fitness. The study reveals a layered mucin‐utilization architecture in which capsular polysaccharides constrain surface access, extracellular CAZymes and peptidases show functional redundancy, and intracellular catabolic pathways create discrete metabolic
Kangsan Kim, Jiwon Lee, Minjeong Kang, Sung Sun Yim, Donghui Choe, Byung‐Kwan Cho   +5 more
wiley   +1 more source

The ribosomal RNA synthesis ratio biomarker in Mycobacterium ulcerans for drug activity evaluation. [PDF]

Infect Dis Poverty
Calvet-Seral J, Sáez-López E, López-Expósito PR, Ferrer-Bazaga S, Vaquero JJ, Ramón-García S, Mendoza-Losana A.   +6 more
europepmc   +1 more source

Immune Biomarkers of Islet Transplant Rejection Revealed by Synthetic Immunological Niche

Advanced Science, EarlyView.
A subcutaneous synthetic immunological niche (IN) enables serial, minimally invasive monitoring of immune responses after islet transplantation. Flow cytometry and transcriptomic profiling of the IN reveal immune‐cell programs associated with graft acceptance and distinct types of rejection.
Jyotirmoy Roy, Abdalmonam Jadou Nejma, Mohammad Tarique, Amod Talekar, Shengli Wu, Brianna Ha, Yifei Jiang, Esma S. Yolcu, Lonnie D. Shea   +8 more
wiley   +1 more source

Ribosomal RNA processing impairments in a B cell immunodeficient patient with WDR75 variants. [PDF]

J Hum Immun
Moreno-Corona N, Valagussa A, Poggi L, Lopez-Ortega O, Masson C, Zarhrate M, Bertrand A, Picard C, Revy P, Bodet D, Rouger J, Castelle M, Fischer A, O'Donohue MF, Kracker S.   +14 more
europepmc   +1 more source

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source

Ribosomal RNA tentacles are targets of free radical damage in mammalian cells during oxidative and inflammatory stress. [PDF]

RSC Chem Biol
Fleming AM, Dingman JC, Burrows CJ.
europepmc   +1 more source

NSUN3‐Associated m5C Modification of tRF5‐GlyTCC Suppresses Colorectal Cancer Progression via RPL23‐Linked Nucleolar Stress and p53‐Associated Autophagy and Enhances 5‐FU Sensitivity

Advanced Science, EarlyView.
This study identifies that NSUN3‐mediated m5C modification stabilizes tRF5‐GlyTCC, linking ribosomal homeostasis, nucleolar stress responses, and p53 signaling changes. This regulatory axis suppresses colorectal cancer and enhances chemotherapy response to 5‐FU, positioning tRF5‐GlyTCC as a potential therapeutic target for improving drug sensitivity in
Xinhui Lv, Can Tang, Feiyang Song, Yu Wu, Yafang Chen, Sicong Liu, Ziwen Yuan, Guihua Wang, Xudong Wang   +8 more
wiley   +1 more source

Nuclear condensates formed by truncated mutant NEK1s impede ribosomal RNA biogenesis and drive motor dysfunction. [PDF]

Nat Commun
Wang Y, Hu W, Huang R, Wu F, Su H, Zang J, Huang X, Liu Y, Ren H, Li J, Zhang M, Zhang Y, Wang G, Hao Z.   +13 more
europepmc   +1 more source

Small Intestinal Bacterial Overgrowth Following Gastrointestinal Cancer Surgery: Current Evidence and Future Perspectives

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Small intestinal bacterial overgrowth (SIBO) has recently gained increasing attention as a potential cause of postoperative gastrointestinal symptoms following gastrointestinal cancer surgery. Surgical procedures can disrupt normal gastrointestinal physiology through anatomical reconstruction, impaired motility, reduced gastric acid secretion,
Toru Aoyama, Haruhiko Cho, Takaki Yoshikawa   +2 more
wiley   +1 more source