Results 261 to 270 of about 1,591,440 (405)

Nuclear ribosomal internal transcribed spacer (ITS) region as a universal DNA barcode marker for Fungi

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2012
Conrad L. Schocha   +7 more
semanticscholar   +1 more source

LncRNA TMEM99 Complexes with IGF2BP2 to Inhibit Autophagy in Lung Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
LncRNA TMEM99 is significantly upregulated in lung adenocarcinoma (LUAD) and correlates with poor prognosis. It promotes LUAD cell proliferation, migration, and invasion while suppressing autophagy. Mechanistically, TMEM99 binds FUBP3 and recruits IGF2BP2 in an m⁶A‐dependent manner to stabilize and enhance p21 mRNA translation, uncovering a novel ...
Zhigang Wu   +12 more
wiley   +1 more source

Alternative Models for Anticancer Drug Discovery From Natural Products Using Binary Tumor‐Microenvironment‐on‐a‐Chip

open access: yesAdvanced Science, EarlyView.
This study presents a binary tumor‐microenvironment‐on‐a‐chip (T‐MOC) system incorporating multicellular tumor spheroids (MCTs) as an alternative preclinical platform to evaluate the efficacy of anticancer natural products. The T‐MOC model reproduces in vivo drug delivery barriers and physiological conditions, enabling morphological analysis to predict
Youngwon Kim   +7 more
wiley   +1 more source

SNORA58 Facilitates Radioresistance via Suppressing JNK1‐Mediated Ferroptosis in Esophageal Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
In ESCC patients, SNORA58 exhibits heterogeneous expression patterns. Its aberrant overexpression stabilizes CTCF by inhibiting ubiquitin‐mediated degradation, leading to the attenuation of JNK1‐mediated ferroptosis induced by radiotherapy through disruption of intracellular iron homeostasis, and ultimately contributes to radioresistance ...
Yinli Zheng   +14 more
wiley   +1 more source

Location of Ribosomal Protein Binding Sites on 16S Ribosomal RNA

open access: green, 1972
Robert A. Zimmermann   +4 more
openalex   +1 more source

Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities

open access: yesAdvanced Science, EarlyView.
Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil   +12 more
wiley   +1 more source

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