Results 261 to 270 of about 523,127 (337)

Chemical nucleases are a robust alternative for RNase H cleavage of human ribosomal RNA. [PDF]

PLoS One
Wesseling H, Krug D, Wehrheim M, Göbel MW, Kaiser S.   +4 more
europepmc   +1 more source

18S Ribosomal RNA [PDF]

, 2020
openaire   +1 more source

Transcriptional regulation of ribosomal RNA gene : actin, myosin and beyond

, 2014
Aishe A. Sarshad
openalex  

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Methylation of Cytidine 1407 Increases the Lifetimes of the A-Site Ground and Excited States of <i>E. coli</i> 16S Ribosomal RNA. [PDF]

J Am Chem Soc
Hilber S, Marotto A, Mitteregger C, Tollinger M, Kreutz C.   +4 more
europepmc   +1 more source

An RNA Secondary Structure Switch between the Inactive and Active Conformations of the Escherichia coli 30 S Ribosomal Subunit

, 1989
Gwen Ericson, Paul Wollenzien
openalex   +1 more source

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

NMR characterisation of the antibiotic resistance-mediating 32mer RNA from the 23S ribosomal RNA. [PDF]

Biomol NMR Assign
Muhs C, Kemper L, Richter C, Lavore F, Weingarth M, Wacker A, Schwalbe H.   +6 more
europepmc   +1 more source

28S Ribosomal RNA [PDF]

, 2020
openaire   +1 more source