Results 21 to 30 of about 516,711 (334)
A creature with a hundred waggly tails: intrinsically disordered proteins in the ribosome [PDF]
, 2013 This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Dunker, A. Keith +6 more
core +2 more sources
Autophagy regulates rRNA synthesis
Nucleus, 2022 Autophagy has emerged as a key regulator of cell metabolism. Recently, we have demonstrated that autophagy is involved in RNA metabolism by regulating ribosomal RNA (rRNA) synthesis.
Yinfeng Xu, Wei Wan
doaj +1 more source
Recognition of Ribosomal RNA Sites in DNA, I. Analysis of the E. coli System [PDF]
, 1965 The evidence recently presented of specific hybridization between bacterial ribosomal RNA and homologous DNA1-3 has indicated the possibility of a biochemical approach to the problem of the identification of ribosomal RNA sites in DNA.
Attardi, Giuseppe +2 more
core +1 more source
Conformational switches control early maturation of the eukaryotic small ribosomal subunit
eLife, 2019 Eukaryotic ribosome biogenesis is initiated with the transcription of pre-ribosomal RNA at the 5’ external transcribed spacer, which directs the early association of assembly factors but is absent from the mature ribosome.
Mirjam Hunziker +5 more
doaj +1 more source
Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA [PDF]
, 2012 Ribosomal RNA undergoes various modifications to optimize ribosomal structure and expand the topological potential of RNA. The most common nucleotide modifications in ribosomal RNA (rRNA) are pseudouridylations and 2'-O methylations (Nm), performed by H ...
Entian, Karl-Dieter +5 more
core +1 more source
Hepatitis C virus 3'UTR regulates viral translation through direct interactions with the host translation machinery. [PDF]
, 2013 The 3' untranslated region (3'UTR) of hepatitis C virus (HCV) messenger RNA stimulates viral translation by an undetermined mechanism. We identified a high affinity interaction, conserved among different HCV genotypes, between the HCV 3'UTR and the host ...
Bai, Yun +2 more
core +2 more sources
Nature Communications, 2019 Arabidopsis AGO1 binds both microRNA (miRNA) and endogenous small interfering RNA (siRNA). Here the authors show that 5′−3′ RNA degradation suppresses siRNA biogenesis from ribosomal RNA to prevent overloading of AGO1 with ribosomal siRNA and maintain ...
Chenjiang You +8 more
doaj +1 more source
HMG-boxes, ribosomopathies and neurodegenerative disease
Frontiers in Genetics, 2023 The UBTF E210K neuroregression syndrome is a predominantly neurological disorder caused by recurrent de novo dominant variants in Upstream Binding Factor, that is, essential for transcription of the ribosomal RNA genes. This unusual form of ribosomopathy
Tom Moss +4 more
doaj +1 more source
Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation. [PDF]
, 2013 The initiation of protein synthesis plays an essential regulatory role in human biology. At the center of the initiation pathway, the 13-subunit eukaryotic translation initiation factor 3 (eIF3) controls access of other initiation factors and mRNA to the
Arias-Palomo, Ernesto +6 more
core +1 more source
RNA polymerase I mutant affects ribosomal RNA processing and ribosomal DNA stability
RNA BiologyTranscription is a major contributor to genomic instability. The ribosomal RNA (rDNA) gene locus consists of a head-to-tail repeat of the most actively transcribed genes in the genome.
Christophe Normand +7 more
doaj +1 more source