Results 31 to 40 of about 516,711 (334)

Recent Advances on the Structure and Function of RNA Acetyltransferase Kre33/NAT10

Cells, 2019
Ribosome biogenesis is one of the most energy demanding processes in the cell. In eukaryotes, the main steps of this process occur in the nucleolus and include pre-ribosomal RNA (pre-rRNA) processing, post-transcriptional modifications, and assembly of ...
Sophie Sleiman, Francois Dragon
doaj   +1 more source

Protocol for Metatranscriptomic analysis of Intestinal Microbiota [PDF]

, 2012
The objective of this publication is to provide the detailed protocol for metartancriptomisc studies of animal intestinal microbiota. The protocol describes isolation of high quality microbial community RNA from the mammalian intestinal content ...
Alvaro Hernandez, Donald Liu, John Alverdy, Valeriy Poroyko, Valeriy Poroyko   +4 more
core   +2 more sources

Protocol dependence of sequencing-based gene expression measurements. [PDF]

PLoS ONE, 2011
RNA Seq provides unparalleled levels of information about the transcriptome including precise expression levels over a wide dynamic range. It is essential to understand how technical variation impacts the quality and interpretability of results, how ...
Tal Raz, Philipp Kapranov, Doron Lipson, Stan Letovsky, Patrice M Milos, John F Thompson   +5 more
doaj   +1 more source

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources

SARS-CoV-2 targets ribosomal RNA biogenesis

Cell Reports
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hinders host gene expression, curbing defenses and licensing viral protein synthesis and virulence.
V. Talya Yerlici, Audrey Astori, Nevraj S. Kejiou, Chris A. Jordan, Negin Khosraviani, Janet N.Y. Chan, Razqallah Hakem, Brian Raught, Alexander F. Palazzo, Karim Mekhail   +9 more
doaj   +1 more source

Ribosomal history reveals origins of modern protein synthesis. [PDF]

PLoS ONE, 2012
The origin and evolution of the ribosome is central to our understanding of the cellular world. Most hypotheses posit that the ribosome originated in the peptidyl transferase center of the large ribosomal subunit.
Ajith Harish, Gustavo Caetano-Anollés
doaj   +1 more source

Loss of m1acp3Ψ Ribosomal RNA Modification Is a Major Feature of Cancer

Cell Reports, 2020
Summary: The ribosome is an RNA-protein complex that is essential for translation in all domains of life. The structural and catalytic core of the ribosome is its ribosomal RNA (rRNA).
Artem Babaian, Katharina Rothe, Dylan Girodat, Igor Minia, Sara Djondovic, Miha Milek, Sandra E. Spencer Miko, Hans-Joachim Wieden, Markus Landthaler, Gregg B. Morin, Dixie L. Mager   +10 more
doaj   +1 more source

Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes [PDF]

, 2013
Introduction: In recent years, there has been an exponential increase in the number of studies aiming to understand the biology of exosomes, as well as other extracellular vesicles.
Berent-Maoz B, Chaput N, Choi DS, Cocucci E, Droin N, Ekström K, Escola JM, Freyssinet JM, György B, Johnstone RM, Kalra H, Keller S, Lehmann BD, Lespagnol A, Lässer C, Lässer C, Mathivanan S, Rajendran L, Ratajczak J, Simpson RJ, Stoorvogel W, Suliman A, Théry C, Turiák L, Valadi H, van der Pol E, van der Pol E, van Niel G, Yu X   +28 more
core   +2 more sources

The 73 S ribosome of Neurospora crassa is the native mitochondrial ribosome [PDF]

, 1977
The effect of the inclusion of EDTA and of heparin, in media used in the isolation of mitochondria, on the mitochindrial previous termribosomenext term has been investigated. 1. 1.
Adelmann, Alberghina, Avadhani, Datema, Grivell, Hallermayer, Kellems, Kroon, Küntzel, Leaver, Leaver, Lizardi, Loening, Monro, Neupert, Neupert, O'Brien, Palmiter, Pene, Schmitt, Taylor, van den Bogert, Vogel, von Rücker, Weiss   +24 more
core   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source