Results 41 to 50 of about 509,011 (342)
Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation. [PDF]
, 2013 The initiation of protein synthesis plays an essential regulatory role in human biology. At the center of the initiation pathway, the 13-subunit eukaryotic translation initiation factor 3 (eIF3) controls access of other initiation factors and mRNA to the
Arias-Palomo, Ernesto +6 more
core +1 more source
The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation [PDF]
, 2017 Ribosome assembly requires the concerted expression of hundreds of genes, which are transcribed by all three nuclear RNA polymerases. Transcription elongation involves dynamic interactions between RNA polymerases and chromatin.
Begley, Victoria Sarah +11 more
core +3 more sources
Ribosomes and ribosomal RNA as chaperones for folding of proteins
Folding and Design, 1997 Provocative recent reports indicate that the large subunits of either prokaryotic or eukaryotic ribosomes have the capacity to promote refolding of denatured enzymes.Salt-washed Escherichia coli ribosomes are shown to promote refolding of denatured rhodanese.
Gisela Kramer +3 more
openaire +3 more sources
Hepatitis C virus 3'UTR regulates viral translation through direct interactions with the host translation machinery. [PDF]
, 2013 The 3' untranslated region (3'UTR) of hepatitis C virus (HCV) messenger RNA stimulates viral translation by an undetermined mechanism. We identified a high affinity interaction, conserved among different HCV genotypes, between the HCV 3'UTR and the host ...
Bai, Yun +2 more
core +2 more sources
A working model for cytoplasmic assembly of H/ACA snoRNPs
FEBS Letters, EarlyView.Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley +1 more source
RNA G-quadruplex structures control ribosomal protein production
Scientific Reports, 2021 Four-stranded G-quadruplex (G4) structures form from guanine-rich tracts, but the extent of their formation in cellular RNA and details of their role in RNA biology remain poorly defined.
Dhaval Varshney +5 more
doaj +1 more source
Effects of alcohol and PARP inhibition on RNA ribosomal engagement in cortical excitatory neurons
Frontiers in Molecular Neuroscience, 2023 We report on the effects of ethanol (EtOH) and Poly (ADP-ribose) polymerase (PARP) inhibition on RNA ribosomal engagement, as a proxy for protein translation, in prefrontal cortical (PFC) pyramidal neurons.
Harish R. Krishnan +10 more
doaj +1 more source
Genomic function during the lampbrush chromosome stage of amphibian oogenesis [PDF]
, 1966 Throughout its lengthy developmental history the disposition of the genetic material in the amphibian oocyte nucleus differs from that in other cell types.
Crippa, Marco +3 more
core +1 more source
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
Heliyon, 2016 Ribosomal translocation catalyzed by EF-G hydrolyzing GTP entails multiple conformational changes of ribosome and positional changes of tRNAs and mRNA in the ribosome.
Ping Xie
doaj +1 more source