Results 41 to 50 of about 1,584,172 (286)

Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression

Science Advances, 2018
Ribosomal RNA sequence variants are conserved, exhibit tissue-specific expression, and are found in actively translating ribosomes. The ribosome, the integration point for protein synthesis in the cell, is conventionally considered a homogeneous ...
Matthew M. Parks, Chad M. Kurylo, R. Dass, Linda Bojmar, L. Bojmar, Linda Bojmar, David C. Lyden, David C. Lyden, C. T. Vincent, C. T. Vincent, S. Blanchard   +10 more
semanticscholar   +1 more source

SARS-CoV-2 targets ribosomal RNA biogenesis

Cell Reports
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hinders host gene expression, curbing defenses and licensing viral protein synthesis and virulence.
V. Talya Yerlici, Audrey Astori, Nevraj S. Kejiou, Chris A. Jordan, Negin Khosraviani, Janet N.Y. Chan, Razqallah Hakem, Brian Raught, Alexander F. Palazzo, Karim Mekhail   +9 more
doaj   +1 more source

Protocol dependence of sequencing-based gene expression measurements. [PDF]

PLoS ONE, 2011
RNA Seq provides unparalleled levels of information about the transcriptome including precise expression levels over a wide dynamic range. It is essential to understand how technical variation impacts the quality and interpretability of results, how ...
Tal Raz, Philipp Kapranov, Doron Lipson, Stan Letovsky, Patrice M Milos, John F Thompson   +5 more
doaj   +1 more source

Cross-site comparison of ribosomal depletion kits for Illumina RNAseq library construction

BMC Genomics, 2018
Background Ribosomal RNA (rRNA) comprises at least 90% of total RNA extracted from mammalian tissue or cell line samples. Informative transcriptional profiling using massively parallel sequencing technologies requires either enrichment of mature poly ...
Zachary T. Herbert, Jamie P. Kershner, Vincent L. Butty, Jyothi Thimmapuram, Sulbha Choudhari, Yuriy O. Alekseyev, Jun Fan, Jessica W. Podnar, Edward Wilcox, Jenny Gipson, Allison Gillaspy, Kristen Jepsen, Sandra Splinter BonDurant, Krystalynne Morris, Maura Berkeley, Ashley LeClerc, Stephen D. Simpson, Gary Sommerville, Leslie Grimmett, Marie Adams, Stuart S. Levine   +20 more
doaj   +1 more source

Loss of m1acp3Ψ Ribosomal RNA Modification Is a Major Feature of Cancer

Cell Reports, 2020
Summary: The ribosome is an RNA-protein complex that is essential for translation in all domains of life. The structural and catalytic core of the ribosome is its ribosomal RNA (rRNA).
Artem Babaian, Katharina Rothe, Dylan Girodat, Igor Minia, Sara Djondovic, Miha Milek, Sandra E. Spencer Miko, Hans-Joachim Wieden, Markus Landthaler, Gregg B. Morin, Dixie L. Mager   +10 more
doaj   +1 more source

HMG-boxes, ribosomopathies and neurodegenerative disease

Frontiers in Genetics, 2023
The UBTF E210K neuroregression syndrome is a predominantly neurological disorder caused by recurrent de novo dominant variants in Upstream Binding Factor, that is, essential for transcription of the ribosomal RNA genes. This unusual form of ribosomopathy
Tom Moss, Tom Moss, Mark S. LeDoux, Mark S. LeDoux, Colyn Crane-Robinson   +4 more
doaj   +1 more source

2′-O-Methylation of Ribosomal RNA: Towards an Epitranscriptomic Control of Translation?

Biomolecules, 2018
Ribosomal RNA (rRNA) undergoes post-transcriptional modification of over 200 nucleotides, predominantly 2′-O-methylation (2′-O-Me). 2′-O-Methylation protects RNA from hydrolysis and modifies RNA strand flexibility but does not contribute to Watson-Crick ...
P. Monaco, V. Marcel, Jean-Jacques Diaz, Frédéric Catez   +3 more
semanticscholar   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Dynamic relationships between ribosomal conformational and RNA positional changes during ribosomal translocation

Heliyon, 2016
Ribosomal translocation catalyzed by EF-G hydrolyzing GTP entails multiple conformational changes of ribosome and positional changes of tRNAs and mRNA in the ribosome.
Ping Xie
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source