Results 91 to 100 of about 254,623 (219)

Ribosome self-assembly leads to overlapping reproduction cycles and increases growth rate [PDF]

arXiv, 2018
In permissive environments, E. coli can double its dry mass every 21 minutes. During this time, ribosomes, RNA polymerases, and the proteome are all doubled. Yet, the question of how to relate bacterial doubling time to other biologically relevant time scales in the growth process remains illusive, due to the complex temporal nesting pattern of these ...
arxiv  

Optimal control of ribosome population for gene expression under periodic nutrient intake [PDF]

J. R. Soc. Interface. 2120230652
Translation of proteins is a fundamental part of gene expression that is mediated by ribosomes. As ribosomes significantly contribute to both cellular mass and energy consumption, achieving efficient management of the ribosome population is also crucial to metabolism and growth.
arxiv   +1 more source

The ribosome prophecy [PDF]

Nature Reviews Molecular Cell Biology, 2015
A prophetic theoretical article, which hypothesized that ribosomes have regulatory roles in controlling gene expression, inspired Maria Barna to rethink the value of purely theoretical scientific publications.
openaire   +3 more sources

Translation elongation can control translation initiation on eukaryotic mRNAs [PDF]

, 2013
Synonymous codons encode the same amino acid, but differ in other biophysical properties. The evolutionary selection of codons whose properties are optimal for a cell generates the phenomenon of codon bias.
Aitken, Anand, Brachmann, Browne, Carlini, Chan, Charneski, Chu, Chu, Chu, Ciandrini, Dana, Firczuk, Fluitt, Gibson, Gould, Grant, Haar, Haar, Hense, Hershberg, Hu, Ikemura, Ingolia, Ingolia, Jeon, Kemp, Kotula, Kudla, Liti, Liu, Lombardi, McCarthy, Merritt, Mirzaei, Moriya, Mossadegh, Nagata, Neafsey, Outchkourov, Patel, Plant, Powell, Qian, Sala-Newby, Salas-Marco, Shalgi, Sikorski, Sinclair, Slimko, Stadler, Stark, Wolin, Yadava, Zhou, Zouridis   +55 more
core   +2 more sources

Origin of the Genetic Code Is Found at the Transition between a Thioester World of Peptides and the Phosphoester World of Polynucleotides

Life, 2019
The early metabolism arising in a Thioester world gave rise to amino acids and their simple peptides. The catalytic activity of these early simple peptides became instrumental in the transition from Thioester World to a Phosphate World.
Hyman Hartman, Temple F. Smith
doaj   +1 more source

From DNA to proteins via the ribosome: Structural insights into the workings of the translation machinery

Human Genomics, 2010
Understanding protein synthesis in bacteria and humans is important for understanding the origin of many human diseases and devising treatments for them.
Agirrezabala Xabier, Frank Joachim
doaj   +1 more source

Microtubule-dependent ribosome localization in C. elegans neurons. [PDF]

, 2017
Subcellular localization of ribosomes defines the location and capacity for protein synthesis. Methods for in vivo visualizing ribosomes in multicellular organisms are desirable in mechanistic investigations of the cell biology of ribosome dynamics. Here,
Ellisman, Mark H, Goncharov, Alexandr, Jin, Yishi, Noma, Kentaro   +3 more
core  

Deoxynivalenol-Induced Proinflammatory Gene Expression: Mechanisms and Pathological Sequelae

Toxins, 2010
The trichothecene mycotoxin deoxynivalenol (DON) is commonly encountered in human cereal foods throughout the world as a result of infestation of grains in the field and in storage by the fungus Fusarium.
James J. Pestka
doaj   +1 more source

Finding sense in the context

eLife, 2020
Ribosomal profiling has shed new light on how ribosomes can ignore stop codons in messenger RNA.
Kim M Keeling, David M Bedwell
doaj   +1 more source

Translation with frameshifting of ribosome along mRNA transcript [PDF]

arXiv, 2015
Translation is an important process for prokaryotic and eukaryotic cells to produce necessary proteins for cell growth. Numerious experiments have been performed to explore the translational properties. Diverse models have also been developed to determine the biochemical mechanism of translation. However, to simplify the majority of the existing models,
arxiv