Results 91 to 100 of about 358,575 (311)

Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease

Nature Communications, 2019
Ribosome biogenesis is a canonical hallmark of cell growth and proliferation. Here we show that execution of Epithelial-to-Mesenchymal Transition (EMT), a migratory cellular program associated with development and tumor metastasis, is fueled by ...
V. Prakash, Brittany B. Carson, Jennifer M. Feenstra, R. Dass, Petra Sekyrová, Ayuko Hoshino, Julian Petersen, Yuan Guo, Matthew M. Parks, Chad M. Kurylo, Jake E. Batchelder, Kristian Haller, Ayako Hashimoto, Helene Rundqivst, John S. Condeelis, C. D. Allis, D. Drygin, M. A. Nieto, M. Andäng, P. Percipalle, J. Bergh, I. Adameyko, A. Ö. Farrants, J. Hartman, D. Lyden, K. Pietras, Scott C Blanchard, C. T. Vincent   +27 more
semanticscholar   +1 more source

The bRPS6-Family Protein RFC3 Prevents Interference by the Splicing Factor CFM3b during Plastid rRNA Biogenesis in Arabidopsis thaliana

Plants, 2020
Plastid ribosome biogenesis is important for plant growth and development. REGULATOR OF FATTY ACID COMPOSITION3 (RFC3) is a member of the bacterial ribosomal protein S6 family and is important for lateral root development. rfc3-2 dramatically reduces the
Yumi Nagashima, Katsutomo Ohshiro, Akiyasu Iwase, Miyuki T. Nakata, Shugo Maekawa, Gorou Horiguchi   +5 more
doaj   +1 more source

Expansion of a novel population of NK cells with low ribosome expression in juvenile dermatomyositis

Frontiers in Immunology, 2022
Juvenile dermatomyositis (JDM) is a pediatric autoimmune disease associated with characteristic rash and proximal muscle weakness. To gain insight into differential lymphocyte gene expression in JDM, peripheral blood mononuclear cells from 4 new-onset ...
Kinsey A. Hilliard, Allison A. Throm, Allison A. Throm, Jeanette T. Pingel, Nermina Saucier, Hani S. Zaher, Anthony R. French, Anthony R. French   +7 more
doaj   +1 more source

EDF1 coordinates cellular responses to ribosome collisions

eLife, 2020
Translation of aberrant mRNAs induces ribosomal collisions, thereby triggering pathways for mRNA and nascent peptide degradation and ribosomal rescue.
Niladri Sinha, A. Ordureau, K. Best, J. A. Saba, Boris Zinshteyn, Elayanambi Sundaramoorthy, Amitkumar Fulzele, D. M. Garshott, T. Denk, M. Thoms, J. Paulo, Wade Harper, E. Bennett, R. Beckmann, R. Green   +14 more
semanticscholar   +1 more source

The Ribosome Biogenesis—Cancer Connection

Cells, 2019
Multifaceted relations link ribosome biogenesis to cancer. Ribosome biogenesis takes place in the nucleolus. Clarifying the mechanisms involved in this nucleolar function and its relationship with cell proliferation: (1) allowed the understanding of the ...
M. Penzo, L. Montanaro, D. Treré, M. Derenzini   +3 more
semanticscholar   +1 more source

PROTEOFORMER: deep proteome coverage through ribosome profiling and MS integration [PDF]

, 2014
An increasing amount of studies integrate mRNA sequencing data into MS-based proteomics to complement the translation product search space. However, several factors, including extensive regulation of mRNA translation and the need for three- or six-frame ...
Crappé, Jeroen, De Keulenaer, Sarah, De Meester, Ellen, De Meyer, Tim, Fijalkowska, Daria, Koch, Alexander, Menschaert, Gerben, Ndah, Elvis, Steyaert, Sandra, Van Criekinge, Wim, Van Damme, Petra   +10 more
core   +1 more source

Antibiotics and the ribosome [PDF]

Molecular Microbiology, 2006
SummaryThe ribosome is one of the main antibiotic targets in the cell. Recent years brought important insights into the mode of interaction of antibiotics with the ribosome and mechanisms of antibiotic action. Ribosome crystallography provided a detailed view of the interactions between antibiotics and rRNA.
Alexander S. Mankin, Tanel Tenson
openaire   +3 more sources

Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes

eLife, 2022
Rapid and accurate mRNA translation requires efficient codon-dependent delivery of the correct aminoacyl-tRNA (aa-tRNA) to the ribosomal A site. In mammals, this fidelity-determining reaction is facilitated by the GTPase elongation factor-1 alpha (eEF1A),
Manuel F Juette, Jordan D Carelli, Emily J Rundlet, Alan Brown, Sichen Shao, Angelica Ferguson, Michael R Wasserman, Mikael Holm, Jack Taunton, Scott C Blanchard   +9 more
doaj   +1 more source

Identification of the prebiotic translation apparatus within the contemporary ribosome [PDF]

, 2009
A structural element that could have existed independently in the prebiotic era was identified at the active site of the contemporary ribosome. It is suggested to have functioned as a proto-ribosome catalyzing peptide bond formation and non-coded ...
Ada Yonath, Anat Bashan, Chen Davidovich, Ilana Agmon   +3 more
core   +1 more source

Differential stoichiometry among core ribosomal proteins [PDF]

Cell Reports 13: 865 - 873, 2015, 2014
Understanding the regulation and structure of ribosomes is essential to understanding protein synthesis and its deregulation in disease. While ribosomes are believed to have a fixed stoichiometry among their core ribosomal proteins (RPs), some experiments suggest a more variable composition.
arxiv   +1 more source