Results 101 to 110 of about 176,411 (317)
Advanced Science, EarlyView.This study demonstrates that prolonged rhythmic 40 Hz light flicker enhances spatial learning by stimulating PV interneuron‐dependent neurogenesis. The light flicker selectively activates PV interneurons, which enhances GABAergic support for the integration of immature neurons in the adult dentate gyrus.
Hai Yan +16 more
wiley +1 more source
Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation
Advanced Science, EarlyView.This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen +7 more
wiley +1 more source
Advanced Science, EarlyView.NPR1 induces lipolysis of stored lipid droplet and enhances mitochondrial oxidative phosphorylation to fuel gastric cancer metastasis. Specifically, NPR1‐mediated activation of PKG directly phosphorylates and activates HSL at Ser855 and Ser951, thereby driving lipolytic processes.
Huafeng Fu +15 more
wiley +1 more source
Antibiotic inhibitors of the bacterial ribosome. [PDF]
, 1968 Bernard Weisblum, Julian Davies
openalex +1 more source
Advanced Science, EarlyView.Tumor‐associated TP53 inactivation correlates with lipid droplet (LD) accumulation. High‐fat diets drive Cyb5r3‐Myh9‐mediated p53 enrichment on LD surfaces, accelerating its degradation while upregulating LD‐promoting factor CD36 expression to establish a feed‐forward loop. LD suppression or dietary intervention restores p53 and inhibits tumorigenesis,
Haiyang Liu +20 more
wiley +1 more source
Translatome and Transcriptome Profiling of Hypoxic-Induced Rat Cardiomyocytes
Molecular Therapy: Nucleic Acids, 2020 Adult cardiac hypoxia as a crucial pathogenesis factor can induce detrimental effects on cardiac injury and dysfunction. The global transcriptome and translatome reflecting the cellular response to hypoxia have not yet been extensively studied in ...
Zhijie Shen, Lixiong Zeng, Zhihui Zhang
doaj
Advanced Science, EarlyView.HPD is identified as an RNA‐binding protein that promotes mRNA translation by binding to RRACH motifs via its double‐stranded RNA‐binding domains. This RNA‐binding activity critically sustains glycolysis in ovarian cancer cells. Disrupting HPD's RNA‐binding function effectively suppresses tumor growth and enhances therapeutic sensitivity, highlighting ...
Fei Xie +21 more
wiley +1 more source
Studies on polynucleotides, XLIX. Stimulation of the binding of aminoacyl-sRNA's to ribosomes by ribotrinucleotides and a survey of codon assignments for 20 amino acids. [PDF]
, 1965 Dieter Söll +6 more
openalex +1 more source