Results 101 to 110 of about 358,575 (311)
Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance.
Nature Chemical Biology, 2020 Many antibiotics inhibit bacterial growth by binding to the ribosome and interfering with protein biosynthesis. Macrolides represent one of the most successful classes of ribosome-targeting antibiotics.
M. Svetlov +6 more
semanticscholar +1 more source
Discrete nascent chain lengths are required for the insertion of presecretory proteins into microsomal membranes. [PDF]
, 1993 Ribosomes synthesizing nascent secretory proteins are targeted to the membrane by the signal recognition particle (SRP), a small ribonucleoprotein that binds to the signal peptide as it emerges from the ribosome.
Walter, P, Wolin, SL
core
Transcription-translation coupling: direct interactions of RNA polymerase with ribosomes and ribosomal subunits. [PDF]
, 2017 In prokaryotes, RNA polymerase and ribosomes can bind concurrently to the same RNA transcript, leading to the functional coupling of transcription and translation.
Blaha, Gregor M +9 more
core +1 more source
Genome-wide survey of ribosome collision
bioRxiv, 2019 In protein synthesis, ribosome movement is not always smooth and is rather often impeded for numerous reasons. Although the deceleration of the ribosome defines the fates of the mRNAs and synthesizing proteins, fundamental issues remain to be addressed ...
Peixun Han +8 more
semanticscholar +1 more source
Clustered bottlenecks in mRNA translation and protein synthesis
, 2003 We construct an algorithm that generates large, band-diagonal transition matrices for a totally asymmetric exclusion process (TASEP) with local hopping rate inhomogeneities.
B. Alberts +12 more
core +1 more source
Molecular interactions between the constituents of small ribosomal subunit [PDF]
arXiv, 2012 Availability of high-resolution crystal structures of ribosomal subunits of different species opens a route to investigate about molecular interactions between its constituents and stabilization strategy. Structural analysis of the small ribosomal subunit shows that primary binder proteins are mainly employed in stabilizing the folded ribosomal RNA by ...
arxiv
Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging
Aging, 2019 The biosynthesis of ribosomes is a complex process that requires the coordinated action of many factors and a huge energy investment from the cell. Ribosomes are essential for protein production, and thus for cellular survival, growth and proliferation ...
Zsófia Turi +3 more
semanticscholar +1 more source
Biotechnology Journal, 2012 AbstractSee accompanying article by Contreras‐Martin et al.
openaire +3 more sources
Toxins, 2011 Fungal toxins, such as those produced by members of the order Hypocreales, have widespread effects on cereal crops, resulting in yield losses and the potential for severe disease and mortality in humans and livestock.
Barbara A. Blackwell +4 more
doaj +1 more source
Nature Communications, 2019 The ribosome, the largest RNA-containing macromolecular machinery in cells, requires metal ions not only to maintain its three-dimensional fold but also to perform protein synthesis.
A. Rozov +8 more
semanticscholar +1 more source