Ribosome traffic on mRNAs maps to gene ontology : genome-wide quantification of translation initiation rates and polysome size regulation [PDF]
, 2013 Peer reviewedPublisher ...
Ciandrini, Luca +2 more
core +2 more sources
Translatome and Transcriptome Profiling of Hypoxic-Induced Rat Cardiomyocytes
Molecular Therapy: Nucleic Acids, 2020 Adult cardiac hypoxia as a crucial pathogenesis factor can induce detrimental effects on cardiac injury and dysfunction. The global transcriptome and translatome reflecting the cellular response to hypoxia have not yet been extensively studied in ...
Zhijie Shen, Lixiong Zeng, Zhihui Zhang
doaj
A ribosome assembly stress response regulates transcription to maintain proteome homeostasis
bioRxiv, 2019 Ribosome biogenesis is a complex and energy-demanding process requiring tight coordination of ribosomal RNA (rRNA) and ribosomal protein (RP) production. Alteration of any step in this process may impact growth by leading to proteotoxic stress.
B. Albert +8 more
semanticscholar +1 more source
Ribosome self-assembly leads to overlapping reproduction cycles and increases growth rate [PDF]
arXiv, 2018 In permissive environments, E. coli can double its dry mass every 21 minutes. During this time, ribosomes, RNA polymerases, and the proteome are all doubled. Yet, the question of how to relate bacterial doubling time to other biologically relevant time scales in the growth process remains illusive, due to the complex temporal nesting pattern of these ...
arxiv
Extensive evolution of cereal ribosome-inactivating proteins translates into unique structural features, activation mechanisms, and physiological roles [PDF]
, 2017 Ribosome-inactivating proteins (RIPs) are a class of cytotoxic enzymes that can depurinate rRNAs thereby inhibiting protein translation. Although these proteins have also been detected in bacteria, fungi, and even some insects, they are especially ...
De Zaeytijd, Jeroen, Van Damme, Els
core +2 more sources
Alkylative damage of mRNA leads to ribosome stalling and rescue by trans translation in bacteria
eLife, 2020 Similar to DNA replication, translation of the genetic code by the ribosome is hypothesized to be exceptionally sensitive to small chemical changes to its template mRNA.
Erica N Thomas +4 more
doaj +1 more source
Optimal control of ribosome population for gene expression under periodic nutrient intake [PDF]
J. R. Soc. Interface. 2120230652Translation of proteins is a fundamental part of gene expression that is mediated by ribosomes. As ribosomes significantly contribute to both cellular mass and energy consumption, achieving efficient management of the ribosome population is also crucial to metabolism and growth.
arxiv +1 more source
Ribosome Profiling: Global Views of Translation.
Cold Spring Harbor Perspectives in Biology, 2018 The translation of messenger RNA (mRNA) into protein and the folding of the resulting protein into an active form are prerequisites for virtually every cellular process and represent the single largest investment of energy by cells.
Nicholas T. Ingolia +2 more
semanticscholar +1 more source
Global analysis of gene expression reveals mRNA superinduction is required for the inducible immune response to a bacterial pathogen. [PDF]
, 2017 The inducible innate immune response to infection requires a concerted process of gene expression that is regulated at multiple levels. Most global analyses of the innate immune response have focused on transcription induced by defined immunostimulatory ...
Barry, Kevin C +2 more
core +3 more sources
Nature Reviews Molecular Cell Biology, 2015 A prophetic theoretical article, which hypothesized that ribosomes have regulatory roles in controlling gene expression, inspired Maria Barna to rethink the value of purely theoretical scientific publications.
openaire +3 more sources