Results 261 to 270 of about 88,539 (283)

Impact of Epicatechin Supplementation on Plasma Proteome Profiles in Obese Men and Women—An Exploratory Approach to Sexual Dimorphism

PROTEOMICS – Clinical Applications, Volume 20, Issue 1, January 2026.
ABSTRACT Purpose Evidence suggests that consuming epicatechin‐rich green tea can increase metabolism in the body, and this metabolic effect might be linked to weight loss in obese subjects. The precise mechanism by which epicatechin influences weight loss is still unclear.
Celso Pereira Batista Sousa‐Filho, Allanis Valon Ferreira, Leo Kei Iwai, Alison Felipe Alencar Chaves, Talita Souza Siqueira, Victoria Silva, Guilherme Ribeiro Romualdo, Rosemari Otton   +7 more
wiley   +1 more source

Exploring ribosome biogenesis in lung adenocarcinoma to advance prognostic methods and immunotherapy strategies. [PDF]

J Transl Med
Song Z, Wang Y, Zhu M, Zhang P, Li Z, Geng X, Cao X, Zheng J, Tang J, Chen L.   +9 more
europepmc   +1 more source

Calorie Restriction Attenuates Transcriptional Aging Signatures in White Matter Oligodendrocytes and Immune Cells of the Monkey Brain

Aging Cell, Volume 25, Issue 1, January 2026.
Our single nuclei RNA sequencing data reveal that long‐term calorie restriction in aged rhesus monkeys reduces neuroinflammation and preserves glial metabolism. In oligodendrocytes, calorie restriction attenuates an immune signature and promotes axonal proximity, while reducing a myelin‐laden microglia population.
Ana T. Vitantonio, Christina Dimovasili, Yuchen Liu, Bingtian Ye, Jou‐Hsuan Roxie Lee, Molly Hartigan, Benjamin Bouchard, Madelyn Ray, Bryce Conner, Kelli L. Vaughan, Julie A. Mattison, Tara L. Moore, Chao Zhang, Douglas L. Rosene   +13 more
wiley   +1 more source

Sequestration of ribosome biogenesis factors in HSV-1 nuclear aggregates revealed by spatially resolved thermal profiling. [PDF]

Sci Adv
Metzger PJ, Reed TJ, Lum KK, Botello JF, Jiang L, Brangwynne CP, Troyanskaya OG, Cristea IM.   +7 more
europepmc   +1 more source

Oocyte Age‐Dependent DNA Damage Can Be Reverted by the DNA Repair Competent Karyoplasm of Young Oocytes

Aging Cell, Volume 25, Issue 1, January 2026.
As females age, oocyte chromosomal aberrations and DNA damage increase in frequency; this condition is believed to be irreversible. By exposing the aged oocyte nuclei to nuclear factors from young oocytes, the negative effects can be effectively suppressed, restoring their developmental competence. ABSTRACT Mammalian fully grown oocytes are believed to
Nataliia Dudko, Tereza Ilcikova, Natalie Novotna, Marta Czernik, Pasqualino Loi, Josef Fulka Jr., Pritha Bhattacharjee, Raffaella Santoro, Helena Fulka   +8 more
wiley   +1 more source

RBIS regulates ribosome biogenesis to affect progression in lung adenocarcinoma. [PDF]

J Transl Med
Pan H, Liao L, Xu S, Xu Y, Chai W, Liu X, Li J, Cao Y, Sun L, Liu Q, Yan M.   +10 more
europepmc   +1 more source

Loss of p62 Binding Allows TIF‐IA Accumulation in Senescence, Which Promotes Phenotypic Changes to Nucleoli and the Senescence Associated Secretory Phenotype

Aging Cell, Volume 25, Issue 1, January 2026.
P62‐TIF‐IA–mediated regulation of senescence and ageing. In healthy tissue, p62 facilitates TIF‐IA turnover. Upon senescence induction, ATM activation increases TIF‐IA phosphorylation at S44, reducing its p62 binding and causing TIF‐IA accumulation.
Hazel C. Thoms, Tyler S. Brant, Katie Duckett, Yizheng Yang, Jinxi Dong, Hongfei Wang, Freya Derby, Oluwatumilara F. Akeke, Faizah Al‐Alayeen, Amy Newell, Piotr Manasterski, Aishwarya Gopalakrishnan, Derek Mann, Fraser R. Millar, Alex Von Kriegsheim, Juan Carlos Acosta, Fiona Oakley, Lesley A. Stark   +17 more
wiley   +1 more source

Targeting Ribosome Biogenesis for Cancer Therapy with Oral Platinum Complexes. [PDF]

JACS Au
Song D, Wang X, Zhao Z, Yang R, Zhang S, Guo Z.   +5 more
europepmc   +1 more source

Lipid Droplet‐Driven Ribosome Collisions Trigger ZAKα‐p38 Signaling to Accelerate Testicular Aging

Aging Cell, Volume 25, Issue 1, January 2026.
Aging‐ and obesity‐driven lipid droplet accumulation in Sertoli cells induces ROS‐mediated ribosome collisions, activating the ZAKα‐p38 pathway to accelerate testicular aging. Pharmacological ZAKα inhibition with Nilotinib rescues age‐related testicular dysfunction, identifying ribotoxic stress as a therapeutic target.
Yanghua Xu, Xiaoyan Shi, Yinghao Yin, Xiaoli Tan, Ningjing Ou, Xiaopeng Tang, Biao Liu, Hongshan Xie, Yuzhuo Chen, Zhitao Han, Jiarong Xu, Zitaiyu Li, Xiaoping Zheng, Hongji Hu, Wenjing Wang, Wanyi Xia, Hao Chen, Yuxin Tang, Liangyu Zhao   +18 more
wiley   +1 more source

Acetylation of microtubule-binding PinX1 orchestrates ribosome biogenesis to nutrient starvation via the RNA polymerase I preinitiation complex. [PDF]

J Biol Chem
Lu G, Yang L, Zhang Q, Zhang S, Xiong Y, Li T, Zhang Y, Liu M, Zhang Y, Wu J, Weng Q, Liu X, Ji J, Wang H, Luo J.   +14 more
europepmc   +1 more source