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SnapShot: Eukaryotic ribosome biogenesis I
Cell, 2023Ribosome production is vital for every cell, and failure causes human diseases. It is driven by ∼200 assembly factors functioning along an ordered pathway from the nucleolus to the cytoplasm. Structural snapshots of biogenesis intermediates from the earliest 90S pre-ribosomes to mature 40S subunits unravel the mechanisms of small ribosome synthesis. To
Ed Hurt, Jingdong Cheng
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Plant-Specific Features of Ribosome Biogenesis
Trends in Plant Science, 2015The biogenesis of eukaryotic ribosomes is a fundamental process involving hundreds of ribosome biogenesis factors (RBFs) in three compartments of the cell, namely the nucleolus, nucleus, and cytoplasm. Many RBFs are involved in the processing of the primary ribosomal (r)RNA transcript, in which three of the four rRNAs are imbedded.
Enrico Schleiff
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Chloroplast Ribosome Biogenesis Factors
Plant And Cell Physiology, 2023Abstract The formation of chloroplasts can be traced back to an ancient event in which a eukaryotic host cell containing mitochondria ingested a cyanobacterium. Since then, chloroplasts have retained many characteristics of their bacterial ancestor, including their transcription and translation machinery.
Lisa-Marie Schmid +3 more
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Ribosome biogenesis and cancer
Acta Histochemica, 2017There is growing evidence indicating that the human pathological conditions characterized by an up-regulated ribosome biogenesis are at an increased risk of cancer onset. At the basis of this relationship is the close interconnection between the ribosome biogenesis and cell proliferation.
Massimo, Derenzini +2 more
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The homeostatic regulation of ribosome biogenesis
Seminars in Cell & Developmental Biology, 2023The continued integrity of biological systems depends on a balance between interdependent elements at the molecular, cellular, and organismal levels. This is particularly true for the generation of ribosomes, which influence almost every aspect of cell and organismal biology.
Chunyang, Ni, Michael, Buszczak
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1991
Publisher Summary This chapter focuses on the concept of ribosome biogenesis in yeast. The formation of functional ribosomes is a highly complex phenomenon requiring the interplay of a large number of molecular processes. Ribosomes contain, depending on their origin, some 60–80 different components, proteins, and RNA molecules, most in a single copy ...
H A, Raué, R J, Planta
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Publisher Summary This chapter focuses on the concept of ribosome biogenesis in yeast. The formation of functional ribosomes is a highly complex phenomenon requiring the interplay of a large number of molecular processes. Ribosomes contain, depending on their origin, some 60–80 different components, proteins, and RNA molecules, most in a single copy ...
H A, Raué, R J, Planta
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Growth control and ribosome biogenesis
Current Opinion in Cell Biology, 2009Ribosomes provide the basis for protein production and this drives cell growth. Recent studies, both in yeast and in higher eukaryotes, are beginning to reveal new mechanisms underlying the elaborate control of ribosome biogenesis, which requires coordinate regulation of all three RNA polymerases.
Harri, Lempiäinen, David, Shore
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Journal of cellular physiology, 2014
The ribosome is a supramolecular ribonucleoprotein complex that functions at the heart of the translation machinery to convert mRNA into protein. Ribosome biogenesis is the primary determinant of translational capacity of the cell and accordingly has an essential role in the control of cell growth in eukaryotes.
Chaillou, Thomas +2 more
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The ribosome is a supramolecular ribonucleoprotein complex that functions at the heart of the translation machinery to convert mRNA into protein. Ribosome biogenesis is the primary determinant of translational capacity of the cell and accordingly has an essential role in the control of cell growth in eukaryotes.
Chaillou, Thomas +2 more
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SnapShot: Eukaryotic ribosome biogenesis II
CellRibosome production is essential for cell growth. Approximately 200 assembly factors drive this complicated pathway that starts in the nucleolus and ends in the cytoplasm. A large number of structural snapshots of the pre-60S pathway have revealed the principles behind large subunit synthesis. To view this SnapShot, open or download the PDF.
Hurt, Ed, Iwasa, Janet, Beckmann, Roland
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Control of ribosome biogenesis in yeast
Trends in Genetics, 1988Abstract Ribosome formation in eukaryotes requires the coordinate expression of the genes for about 80 different RNA and protein components. These genes are widely dispersed over the genome, are present in various multiplicities and are transcribed by three different RNA polymerases.
R J, Planta, H A, Raué
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