Results 251 to 260 of about 142,894 (282)
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1991
Publisher Summary This chapter focuses on the concept of ribosome biogenesis in yeast. The formation of functional ribosomes is a highly complex phenomenon requiring the interplay of a large number of molecular processes. Ribosomes contain, depending on their origin, some 60–80 different components, proteins, and RNA molecules, most in a single copy ...
H A, Raué, R J, Planta
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Publisher Summary This chapter focuses on the concept of ribosome biogenesis in yeast. The formation of functional ribosomes is a highly complex phenomenon requiring the interplay of a large number of molecular processes. Ribosomes contain, depending on their origin, some 60–80 different components, proteins, and RNA molecules, most in a single copy ...
H A, Raué, R J, Planta
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Ribosome biogenesis in cancer: new players and therapeutic avenues
Nature Reviews Cancer, 2017 The ribosome is a complex molecular machine composed of numerous distinct proteins and nucleic acids and is responsible for protein synthesis in every living cell.
Joffrey Pelletier, Siniša Volarevic
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Control of ribosome biogenesis in yeast
Trends in Genetics, 1988Abstract Ribosome formation in eukaryotes requires the coordinate expression of the genes for about 80 different RNA and protein components. These genes are widely dispersed over the genome, are present in various multiplicities and are transcribed by three different RNA polymerases.
R J, Planta, H A, Raué
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Biogenesis of Ribosomes in Eukaryotes
1980The biogenesis of ribosomes in eukaryotes involves the generation in the cell of the constituent core rRNA molecules and their interaction with about 80 distinct proteins to form the two mature ribosomal particles. Therefore, the ribosome is not only the principal organelle in gene expression, but it is also one of the best-understood models of the ...
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Ribosome biogenesis and function in development and disease
Development, 2023ABSTRACT Although differential transcription drives the development of multicellular organisms, the ultimate readout of a protein-coding gene is ribosome-dependent mRNA translation. Ribosomes were once thought of as uniform molecular machines, but emerging evidence indicates that the complexity and diversity of ribosome biogenesis and ...
Chunyang Ni, Michael Buszczak
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Role of the yeast ribosomal protein L16 in ribosome biogenesis
The FEBS Journal, 2016Most ribosomal proteins play essential roles in ribosome synthesis and function. In this study, we have analysed the contribution of yeast ribosomal protein L16 to ribosome biogenesis. We show that in vivo depletion of the essential L16 protein results in a deficit in 60S subunits and the appearance of half‐mer polysomes.
Francisco J, Espinar-Marchena +5 more
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Ribosome biogenesis: of knobs and RNA processing
Experimental Cell Research, 2004The synthesis of ribosomes in eukaryotes involves processing of pre-ribosomal RNA (pre-rRNA) and sequential assembly of a large number of ribosomal proteins on the rRNAs. Although we have gained tremendous insights into the processing of pre-rRNA intermediates in the last three decades, little was known about the dynamic nature of ribosome biogenesis ...
Sander, Granneman, Susan J, Baserga
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The Structure and Biogenesis of Yeast Ribosomes
1991Publisher Summary This chapter reviews the recent progress in studies of the biogenesis and structure of yeast ribosomes, emphasizing results derived from experiments using classical and molecular genetics. Studies of the biosynthesis of the yeast ribosome offer an opportunity to investigate the coordinate expression of a moderately large set of ...
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The Nucleolus and Ribosome Biogenesis
1985I. Introduction.- II. Ribosomal Genes.- II. 1. Definitions.- II.2. Ribosomal RNA Genes.- II.2.1. Multiplicity.- II.2.2. Chromosomal Location.- II.2.3. Extrachromosomal rRNA Genes.- II.2.4. Organization and Structure.- II.2.4.1. Saccharomyces cerevisiae.- II.2.4.2. Tetrahymena.- II.2.4.3. Drosophila.- II.2.4.4. Xenopus laevis.- II.2.4.5. Higher Plants.-
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SnapShot: Eukaryotic ribosome biogenesis II
CellRibosome production is essential for cell growth. Approximately 200 assembly factors drive this complicated pathway that starts in the nucleolus and ends in the cytoplasm. A large number of structural snapshots of the pre-60S pathway have revealed the principles behind large subunit synthesis. To view this SnapShot, open or download the PDF.
Hurt, Ed, Iwasa, Janet, Beckmann, Roland
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