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Biogenesis of Ribosomes in Eukaryotes
1980The biogenesis of ribosomes in eukaryotes involves the generation in the cell of the constituent core rRNA molecules and their interaction with about 80 distinct proteins to form the two mature ribosomal particles. Therefore, the ribosome is not only the principal organelle in gene expression, but it is also one of the best-understood models of the ...
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Ribosome biogenesis and function in development and disease
Development, 2023ABSTRACT Although differential transcription drives the development of multicellular organisms, the ultimate readout of a protein-coding gene is ribosome-dependent mRNA translation. Ribosomes were once thought of as uniform molecular machines, but emerging evidence indicates that the complexity and diversity of ribosome biogenesis and ...
Chunyang Ni, Michael Buszczak
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Role of the yeast ribosomal protein L16 in ribosome biogenesis
The FEBS Journal, 2016Most ribosomal proteins play essential roles in ribosome synthesis and function. In this study, we have analysed the contribution of yeast ribosomal protein L16 to ribosome biogenesis. We show that in vivo depletion of the essential L16 protein results in a deficit in 60S subunits and the appearance of half‐mer polysomes.
Francisco J, Espinar-Marchena +5 more
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Ribosome biogenesis: of knobs and RNA processing
Experimental Cell Research, 2004The synthesis of ribosomes in eukaryotes involves processing of pre-ribosomal RNA (pre-rRNA) and sequential assembly of a large number of ribosomal proteins on the rRNAs. Although we have gained tremendous insights into the processing of pre-rRNA intermediates in the last three decades, little was known about the dynamic nature of ribosome biogenesis ...
Sander, Granneman, Susan J, Baserga
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The Structure and Biogenesis of Yeast Ribosomes
1991Publisher Summary This chapter reviews the recent progress in studies of the biogenesis and structure of yeast ribosomes, emphasizing results derived from experiments using classical and molecular genetics. Studies of the biosynthesis of the yeast ribosome offer an opportunity to investigate the coordinate expression of a moderately large set of ...
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The Nucleolus and Ribosome Biogenesis
1985I. Introduction.- II. Ribosomal Genes.- II. 1. Definitions.- II.2. Ribosomal RNA Genes.- II.2.1. Multiplicity.- II.2.2. Chromosomal Location.- II.2.3. Extrachromosomal rRNA Genes.- II.2.4. Organization and Structure.- II.2.4.1. Saccharomyces cerevisiae.- II.2.4.2. Tetrahymena.- II.2.4.3. Drosophila.- II.2.4.4. Xenopus laevis.- II.2.4.5. Higher Plants.-
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SnapShot: Eukaryotic ribosome biogenesis II
CellRibosome production is essential for cell growth. Approximately 200 assembly factors drive this complicated pathway that starts in the nucleolus and ends in the cytoplasm. A large number of structural snapshots of the pre-60S pathway have revealed the principles behind large subunit synthesis. To view this SnapShot, open or download the PDF.
Hurt, Ed, Iwasa, Janet, Beckmann, Roland
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Ribosome biogenesis: from structure to dynamics.
International review of cell and molecular biology, 2010In this chapter we describe the status of the research concerning the nucleolus, the major nuclear body. The nucleolus has been recognized as a dynamic organelle with many more functions than one could imagine. In fact, in addition to its fundamental role in the biogenesis of preribosomes, the nucleolus takes part in many other cellular processes and ...
Cisterna B, BIGGIOGERA, MARCO
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Ribosome biogenesis factors—from names to functions
EMBO Journal, 2023Ulrike Kutay, Ivo Zemp, Chiara Ruggeri
exaly
Biogenesis of ribosomes in Plasmodium berghei
Military Medicine, 1969K, Tokuyasu, J, Ilan, J, Ilan
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