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Biogenesis of Ribosomes in Eukaryotes
1980The biogenesis of ribosomes in eukaryotes involves the generation in the cell of the constituent core rRNA molecules and their interaction with about 80 distinct proteins to form the two mature ribosomal particles. Therefore, the ribosome is not only the principal organelle in gene expression, but it is also one of the best-understood models of the ...
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Control points in eucaryotic ribosome biogenesis
Biochemistry and Cell Biology, 1991Ribosome biogenesis in eucaryotic cells involves the coordinated synthesis of four rRNA species, transcribed by RNA polymerase I (18S, 28S, 5.8S) and RNA polymerase III (5S), and approximately 80 ribosomal proteins translated from mRNAs synthesized by RNA polymerase II.
D E, Larson, P, Zahradka, B H, Sells
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Inhibition ofChaperone-Dependent Bacterial Ribosome Biogenesis
2008In Escherichia coli, the molecular chaperone HSP70 (DnaK) is necessary for 30S and 50S ribosomal subunit assembly at temperatures above 37 degrees C. Inhibitors of DnaK should therefore hinder ribosome biogenesis, in addition to all of the other DnaK-dependent cellular functions.
Refaii A, Al, J. H., Alix
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Ribosome biogenesis: from structure to dynamics.
International review of cell and molecular biology, 2010In this chapter we describe the status of the research concerning the nucleolus, the major nuclear body. The nucleolus has been recognized as a dynamic organelle with many more functions than one could imagine. In fact, in addition to its fundamental role in the biogenesis of preribosomes, the nucleolus takes part in many other cellular processes and ...
Cisterna B, BIGGIOGERA, MARCO
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Ribosomal biogenesis stress and p53 activation [PDF]
, 2012 Međunarodni simpozij održan je 10. i 11. listopada 2013. u Biološkoj dvorani Medicinskog fakulteta Sveučilišta u Zagrebu. Na simpoziju u čast akademika Nikole Škreba (1920-1993), pionira razvojne biologije, osnivača Zagrebačke embriološke škole te dugogodišnjeg pročelnika Katedre za medicinsku biologiju Medicinskog fakulteta Sveučilišta u Zagrebu ...
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MYC as a regulator of ribosome biogenesis and protein synthesis
Nature Reviews Cancer, 2010Jan Van Riggelen, Dean W Felsher
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Ribosome biogenesis in cancer: new players and therapeutic avenues
Nature Reviews Cancer, 2017Joffrey Pelletier +2 more
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Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis
Cell, 2016Shigehiro A Kawashima +2 more
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