Results 81 to 90 of about 88,539 (283)

The 73 S ribosome of Neurospora crassa is the native mitochondrial ribosome [PDF]

, 1977
The effect of the inclusion of EDTA and of heparin, in media used in the isolation of mitochondria, on the mitochindrial previous termribosomenext term has been investigated. 1. 1.
Adelmann, Alberghina, Avadhani, Datema, Grivell, Hallermayer, Kellems, Kroon, Küntzel, Leaver, Leaver, Lizardi, Loening, Monro, Neupert, Neupert, O'Brien, Palmiter, Pene, Schmitt, Taylor, van den Bogert, Vogel, von Rücker, Weiss   +24 more
core   +1 more source

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

An RNA-binding switch drives ribosome biogenesis and tumorigenesis downstream of RAS oncogene [PDF]

, 2021
Muhammad S. Azman, Martin Dodel, Federica Capraro, Rupert Faraway, Maria Dermit, Wanling Fan, Jernej Ule, Faraz K. Mardakheh   +7 more
openalex   +1 more source

Autopolyploidization‐Induced Chromatin Remodeling Regulates Leaf Size Variation in Brassica rapa

Advanced Science, EarlyView.
This study demonstrates that monoploid, diploid, and autotetraploid Brassica rapa lines derived from the same genome exhibit distinct leaf morphology. Ploidy changes remodel chromatin accessibility and histone modifications to regulate gene expression, while key transcription factors BrGRF13 and BrARF11 control leaf size and polarity, driving ...
Haoyuan Dong, Yanhong Liu, Yuanming Liu, Shuxin Xuan, Huanhuan Chen, Lai Wei, Guibao Zhang, Hongcui Pei, Zilong Dai, Yanhua Wang, Jinzhu Qiao, Shuangxia Luo, Xueping Chen, Yiguo Hong, Jianjun Zhao, Shuxing Shen, Zefu Lu, Aixia Gu   +17 more
wiley   +1 more source

Transfer RNA-derived small RNAs in the cancer transcriptome [PDF]

, 2016
The cellular lifetime includes stages such as differentiation, proliferation, division, senescence and apoptosis.These stages are driven by a strictly ordered process of transcription dynamics.
A Dueck, A Sobala, AE Hall, AM Burroughs, C Cole, C Fricke, D Green, D Haussecker, D Kim, Darrell Green, DM Thompson, DP Bartel, DR Rhodes, FE Nicolas, GL Hager, H Fu, H Goodarzi, I Salaverria, JM Perkel, M Ghildiyal, M Talpaz, MS Pagter de, NC Schopman, O Rechavi, P Adjibade, P Ivanov, P Kumar, P Kumar, Q Wang, R Levitz, RL Maute, S Yamasaki, SC Stearns, T Uchiumi, Tamas Dalmay, U Harms, William D. Fraser, YS Lee, Z Li   +38 more
core   +1 more source

Spatio‐Temporal Proteomic Landscape Reveals Early Warning Signals of Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
This study constructs a proteomic atlas of esophageal squamous cell carcinoma (ESCC) progression using esophageal biopsy samples. It identifies moderate dysplasia as the critical turning stage and a seven‐protein panel for early detection. Functionally, GBP6 loss promotes ESCC progression via cell cycle and epithelial‐mesenchymal transition (EMT ...
Xumiao Li, Jie Yuan, Min Gao, Jibin Liu, Qinqin Wang, Yaqi Zhang, Mingtao Cao, Xiaolin Hu, Hui Yang, Jun Li, Chen Li, Xiaoguang Li, Hui Wang   +12 more
wiley   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Diverse Regulators of Human Ribosome Biogenesis Discovered by Changes in Nucleolar Number

Cell Reports, 2018
Summary: Ribosome biogenesis is a highly regulated, essential cellular process. Although studies in yeast have established some of the biological principles of ribosome biogenesis, many of the intricacies of its regulation in higher eukaryotes remain ...
Katherine I. Farley-Barnes, Kathleen L. McCann, Lisa M. Ogawa, Janie Merkel, Yulia V. Surovtseva, Susan J. Baserga   +5 more
doaj   +1 more source

Translation termination depends on the sequential ribosomal entry of eRF1 and eRF3.

, 2019
Translation termination requires eRF1 and eRF3 for polypeptide-and tRNA-release on stop codons. Additionally, Dbp5/DDX19 and Rli1/ABCE1 are required; however, their function in this process is currently unknown.
Beissel , C., Hampe , I., Karki, P., Krebber, H., Neumann, B., Uhse, S.   +5 more
core   +1 more source

Traffic into silence: endomembranes and post-transcriptional RNA silencing. [PDF]

, 2014
microRNAs (miRNAs) and small interfering RNAs (siRNAs) are small RNAs that repress gene expression at the post-transcriptional level in plants and animals. Small RNAs guide Argonaute-containing RNA-induced silencing complexes to target RNAs in a sequence-
Chen, Xuemei, Kim, Yun Ju, Maizel, Alexis   +2 more
core   +3 more sources