Results 81 to 90 of about 173,360 (283)

Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome

Nature Communications, 2023
Mitochondria contain their own genetic information and a dedicated translation system to express it. The mitochondrial ribosome is assembled from mitochondrial-encoded RNA and nuclear-encoded ribosomal proteins.
Thu Giang Nguyen, Christina Ritter, Eva Kummer   +2 more
doaj   +1 more source

Hypoxia‐Induced circPRELID2 Promotes Gastric Cancer Metastasis by Facilitating ZEB2 Translation via PCBP1 O‐GlcNAcylation

Advanced Science, EarlyView.
Under hypoxia, HIF1A is directly bound to the PRELID2 promoter to increase PRELID2 pre‐mRNA expression, followed by the DYRK1A–SFPQ–SAM68 complex binding to Alu‐containing introns in PRELID2 pre‐mRNA, leading to circPRELID2 circularization. CircPRELID2 interacts with PCBP1 and promotes its cytoplasmic retention.
Pengshan Zhang, Zai Luo, Yitian Xu, Yuan Zhang, Renchao Zhang, Nadina Paerhati, Shaopeng Zhang, Qianqian Cai, Zhengjun Qiu, Chen Huang   +9 more
wiley   +1 more source

Downregulation of ribosome biogenesis during early forebrain development

eLife, 2018
Forebrain precursor cells are dynamic during early brain development, yet the underlying molecular changes remain elusive. We observed major differences in transcriptional signatures of precursor cells from mouse forebrain at embryonic days E8.5 vs.
Kevin F Chau, Morgan L Shannon, Ryann M Fame, Erin Fonseca, Hillary Mullan, Matthew B Johnson, Anoop K Sendamarai, Mark W Springel, Benoit Laurent, Maria K Lehtinen   +9 more
doaj   +1 more source

BLOC1S1 Attenuates B. Melitensis 16M LPS‐Triggered Autophagy by Spatial Confinement of TDP‐43

Advanced Science, EarlyView.
This study explores how B. melitensis 16M LPS and BLOC1S1 regulate autophagy in goat spermatogonial stem cells. The 16M LPS is activating AMPK‐dependent autophagy, increasing LC3B‐II/I ratios and lysosomal genes, while Escherichia coli LPS shows no effect.
Shicheng Wan, Miao Han, Mengfei Zhang, Wenbo Chen, Fangde Xie, Xuan Luo, Wenping Wu, Congliang Wang, Donghui Yang, Bin Han, Haijing Zhu, Haisheng Yu, Na Li, Jinlian Hua   +13 more
wiley   +1 more source

Isocitrate dehydrogenase wt and IDHmut adult-type diffuse gliomas display distinct alterations in ribosome biogenesis and 2’O-methylation of ribosomal RNA [PDF]

, 2023
Hermes Paraqindes, Nour‐El‐Houda Mourksi, Samantha Ballesta, Jordan Hedjam, Fleur Bourdelais, Tanguy Fenouil, Thiébaud Picart, Frédéric Catez, Théo Combe, Anthony Ferrari, Janice Kielbassa, Emilie Thomas, Laurie Tonon, Alain Viari, Valéry Attignon, Marjorie Carrère, Jessie Perrossier, Stéphane Giraud, Christophe Vanbelle, Mathieu Gabut, Danny Bergeron, Michelle S Scott, Luis Castro Vega, Nathalie Magne, Emmanuelle Huillard, Marc Sanson, David Meyronet, Jean‐Jacques Diaz, François Ducray, Virginie Marcel, Sébastien Durand   +30 more
openalex   +1 more source

Integrative Omics Reveal Female‐Specific Benefits of p16+ Cell Clearance in Aging Mice

Advanced Science, EarlyView.
Aging causes accumulation of p16⁺ senescent cells that promote inflammation and dysfunction. Multi‐omics analyses reveal striking sex differences in senescent cell burden and clearance: females accumulate more p16⁺ cells, especially in the liver, and their removal rejuvenates molecular and functional profiles.
Yao Lin, Boshi Wang, Mengling Huang, Justina C. Wolters, Marco Demaria   +4 more
wiley   +1 more source

Genetic and Epigenetic Regulation of Skeletal Muscle Ribosome Biogenesis with Exercise

bioRxiv, 2020
Ribosomes are the macromolecular engines of protein synthesis. Skeletal muscle ribosome biogenesis is stimulated by exercise, but the contribution of ribosomal DNA (rDNA) copy number and methylation to exercise-induced rDNA transcription is unclear.
V. Figueiredo, Yuan Wen, Björn A. Alkner, R. Fernandez-Gonzalo, J. Norrbom, Ivan J. Vechetti, Taylor R. Valentino, C. Mobley, G. Zentner, C. Peterson, J. McCarthy, Kevin A. Murach, F. Walden   +12 more
semanticscholar   +1 more source

CSN6 Promotes Pancreatic Cancer Progression and Gemcitabine Resistance via Antagonizing DCAF1‐Mediated Ubiquitination of NPM1

Advanced Science, EarlyView.
COP9 signalosome subunit 6 (CSN6) promotes the auto‐ubiquitination and degradation of DDB1‐CUL4 associated factor 1 (DCAF1), thereby antagonizing DCAF1‐mediated ubiquitination of Nucleophosmin (NPM1). This stabilization of NPM1 enhances the ribosome biogenesis process and the translation of specific gemcitabine‐resistance proteins, ultimately driving ...
Yijing Zhang, Han Gao, Aiwen Tang, Haiwen Lyu, Zongmin Fan, Jiahui Guo, Yuzhi Wang, Hairong Yi, Qihao Pan, Haidan Luo, Baifu Qin, Boyu Zhang, Xiangqi Meng, Qingxin Liu, Mong‐Hong Lee   +14 more
wiley   +1 more source

Diverse Regulators of Human Ribosome Biogenesis Discovered by Changes in Nucleolar Number

Cell Reports, 2018
Summary: Ribosome biogenesis is a highly regulated, essential cellular process. Although studies in yeast have established some of the biological principles of ribosome biogenesis, many of the intricacies of its regulation in higher eukaryotes remain ...
Katherine I. Farley-Barnes, Kathleen L. McCann, Lisa M. Ogawa, Janie Merkel, Yulia V. Surovtseva, Susan J. Baserga   +5 more
doaj   +1 more source

Coupled protein synthesis and ribosome-guided piRNA processing on mRNAs

Nature Communications, 2021
Ribosome can mediate piRNA biogenesis from long non-coding RNAs following translation of the short open reading frames. Here the authors show that 80S ribosome also guides piRNA production from 3’ UTR of protein-coding genes after translation of long ...
Yu H. Sun, Ruoqiao Huiyi Wang, Khai Du, Jiang Zhu, Jihong Zheng, Li Huitong Xie, Amanda A. Pereira, Chao Zhang, Emiliano P. Ricci, Xin Zhiguo Li   +9 more
doaj   +1 more source