Results 151 to 160 of about 25,873 (253)
Biosynthesis, Structure, and Antibiotic Properties of Gelatinamin A, a Triculamin‐Like Lasso Peptide
ChemBioChem, Volume 27, Issue 10, 27 May 2026.Biosynthesis of the class V lasso peptide gelatinamin A was elucidated by heterologous expression of the gel biosynthetic gene cluster in Bacillus subtilis. Its 3D structure was determined by NMR, and tailoring enzymes GelT and GelP were fully reconstituted in vitro.
Tiziana Svenningsen +9 more
wiley +1 more source
Advanced Science, Volume 13, Issue 29, 22 May 2026.To combat BET inhibitor resistance in triple‐negative breast cancer, we developed two single‐cell computational frameworks. FR20 quantifies resistance by integrating ferroptosis‐related gene signatures, while D‐FR20 screens for potential re‐sensitizers.
Haizhou Liu +6 more
wiley +1 more source
Advanced Science, Volume 13, Issue 26, 8 May 2026.CircMT‐RNR2 promotes wound healing by enhancing fibroblast proliferation, migration, contraction, and extracellular matrix (ECM) production. It sustains mitochondrial redox balance by stabilizing the antioxidant protein PRDX3, thereby reducing ROS‐induced damage. In diabetic foot ulcers, hypoxia, hyperglycemia, and reduced FGF2 and EGF expression lower
Guanglin Niu +13 more
wiley +1 more source
Advanced Science, Volume 13, Issue 26, 8 May 2026.Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su +4 more
wiley +1 more source
An unusual type I ribosome-inactivating protein from Agrostemma githago L. [PDF]
Sci Rep, 2020 Weise C +7 more
europepmc +1 more source
Advanced Science, Volume 13, Issue 25, 4 May 2026.The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo +8 more
wiley +1 more source
Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss
Advanced Science, Volume 13, Issue 29, 22 May 2026.. ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao +9 more
wiley +1 more source
Programmable RNA N6,2´‐O‐Dimethyladenosine Editing
Advanced Science, Volume 13, Issue 29, 22 May 2026.ABSTRACT N6,2’‐O‐dimethyladenosine (m6Am) is a prevalent RNA modification located at the first transcribed nucleotide adjacent to the 5′ cap of mRNAs, where it has been implicated in gene regulation. However, the lack of methods for precise, transcript‐specific manipulation of m6Am has limited its functional dissection.
Yang Li +9 more
wiley +1 more source
Genetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review
American Journal of Medical Genetics Part A, Volume 200, Issue 5, Page 993-1003, May 2026.ABSTRACT Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase (SMS) gene, resulting in decreased or ...
Elizabeth A. VanSickle +26 more
wiley +1 more source