Results 21 to 30 of about 26,910 (280)

Ribosome Inactivating Proteins: From Plant Defense to Treatments against Human Misuse or Diseases [PDF]

Toxins, 2018
Ribosome inactivating proteins (RIPs) form a vast family of hundreds of toxins from plants, fungi, algae, and bacteria. RIP activities have also been detected in animal tissues.
Julien Barbier, Daniel Gillet
openalex   +3 more sources

Cytotoxicity Effect of Quinoin, Type 1 Ribosome-Inactivating Protein from Quinoa Seeds, on Glioblastoma Cells. [PDF]

Toxins (Basel), 2021
Ribosome-inactivating proteins (RIPs) are found in several edible plants and are well characterized. Many studies highlight their use in cancer therapy, alone or as immunoconjugates, linked to monoclonal antibodies directed against target cancer cells ...
Rotondo R, Ragucci S, Castaldo S, Oliva MA, Landi N, Pedone PV, Arcella A, Di Maro A.   +7 more
europepmc   +2 more sources

Overexpression of the ribosome-inactivating protein OsRIP1 modulates the jasmonate signaling pathway in rice. [PDF]

Front Plant Sci
Ribosome-inactivating proteins (RIPs) are plant enzymes that target the rRNA. The cytoplasmic RIP, called OsRIP1, plays a crucial role in regulating jasmonate, a key plant hormone.
Chen S, De Zutter N, Meijer A, Gistelinck K, Wytynck P, Verbeke I, Osterne VJS, Kondeti S, De Meyer T, Audenaert K, Van Damme EJM.   +10 more
europepmc   +2 more sources

Ribosome-inactivating proteins [PDF]

Virulence, 2013
Ribosome-inactivating proteins (RIPs) were first isolated over a century ago and have been shown to be catalytic toxins that irreversibly inactivate protein synthesis. Elucidation of atomic structures and molecular mechanism has revealed these proteins to be a diverse group subdivided into two classes.
Walsh, M.J., Dodd, J.E., Hautbergue, G.M.   +2 more
openaire   +4 more sources

Primary Sequence and Three-Dimensional Structural Comparison between Malanin and Ricin, a Type II Ribosome-Inactivating Protein. [PDF]

Toxins (Basel)
Malanin is a new type II ribosome-inactivating protein (RIP) purified from Malania oleifera, a rare, endangered tree is only found in the southwest of Guangxi Province and the southeast of Yunnan Province, China.
Yuan Y, Wu S, Day PJR.
europepmc   +2 more sources

Maize ribosome-inactivating protein uses Lys158-lys161 to interact with ribosomal protein P2 and the strength of interaction is correlated to the biological activities. [PDF]

PLoS ONE, 2012
Ribosome-inactivating proteins (RIPs) inactivate prokaryotic or eukaryotic ribosomes by removing a single adenine in the large ribosomal RNA. Here we show maize RIP (MOD), an atypical RIP with an internal inactivation loop, interacts with the ribosomal ...
Yuen-Ting Wong, Yiu-Ming Ng, Amanda Nga-Sze Mak, Kong-Hung Sze, Kam-Bo Wong, Pang-Chui Shaw   +5 more
doaj   +1 more source

Ribosome-Inactivating and Related Proteins [PDF]

Toxins, 2015
Ribosome-inactivating proteins (RIPs) are toxins that act as N-glycosidases (EC 3.2.2.22). They are mainly produced by plants and classified as type 1 RIPs and type 2 RIPs. There are also RIPs and RIP related proteins that cannot be grouped into the classical type 1 and type 2 RIPs because of their different sizes, structures or functions. In addition,
Schrot, Joachim, Weng, Alexander, Melzig, Matthias F.   +2 more
openaire   +4 more sources

Biological Activities of Ribosome-Inactivating Proteins

Toxins, 2023
After more than 50 years of research, studies on the structure and biological activities of ribosome-inactivating proteins (RIPs) continue to provide a field of great interest within the scientific community, both for the health risks they pose and their applications in medicine and biotechnology [...]
Citores González, Lucía, Ferreras Rodríguez, José Miguel   +1 more
openaire   +4 more sources

Revising the taxonomic distribution, origin and evolution of ribosome inactivating protein genes. [PDF]

PLoS One, 2013
Ribosome inactivating proteins are enzymes that depurinate a specific adenine residue in the alpha-sarcin-ricin loop of the large ribosomal RNA, being ricin and Shiga toxins the most renowned examples.
Lapadula WJ, Sánchez Puerta MV, Juri Ayub M.   +2 more
europepmc   +2 more sources

Suicide nanoplasmids coding for ribosome-inactivating proteins [PDF]

European Journal of Pharmaceutical Sciences, 2022
Conventional eukaryotic expression plasmids contain a DNA backbone that is dispensable for the cellular expression of the transgene. In order to reduce the vector size, minicircle DNA technology was introduced. A drawback of the minicircle technology are considerable production costs.
Mitdank, Hardy, Tröger, Meike, Sonntag, Alexander, Shirazi, Nima Amini, Woith, Eric, Fuchs, Hendrik, Kobelt, Dennis, Walther, Wolfgang, Weng, Alexander   +8 more
openaire   +2 more sources