Structure of Ribosome-Inactivating Protein from <i>Mirabilis jalapa</i> and Its L12-Stalk-Dependent Inhibition of <i>Escherichia coli</i> Ribosome. [PDF]
Toxins (Basel)Mirabilis antiviral protein (MAP) is the type I ribosome-inactivating protein (RIP), which consists of an RNA N-glycosylase domain with no carbohydrate-binding domain.
Nishida N +7 more
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Functional analysis of RIP toxins from the Drosophila endosymbiont Spiroplasma poulsonii
BMC Microbiology, 2019 Background Insects frequently live in close relationship with symbiotic bacteria that carry out beneficial functions for their host, like protection against parasites and viruses. However, in some cases, the mutualistic nature of such associations is put
Mario Gonzalo Garcia-Arraez +3 more
doaj +1 more source
Winter Aconite (Eranthis hyemalis) Lectin as a cytotoxic effector in the lifecycle of Caenorhabditis elegans [PDF]
PeerJ, 2015 The lectin found in the tubers of the Winter Aconite (Eranthis hyemalis) plant is an N-acetyl-D-galactosamine specific Type II Ribosome Inactivating Protein (RIP); Type II RIPs have shown anti-cancer properties, and hence have potential as therapeutic ...
Marie-Therese McConnell +4 more
doaj +2 more sources
Recombinant tritin protein exhibits antiviral activity against zucchini yellow mosaic virus. [PDF]
BMC Plant BiolBackground Ribosome-inactivating proteins (RIPs) are a group of proteins known to inhibit protein synthesis and contribute to plant defense responses. Although the antiviral properties of various RIPs have been demonstrated, the antiviral potential of ...
Demi̇rel S, Usta M, Korkmaz G, Kurt Z.
europepmc +2 more sources
Structural and Functional Investigation and Pharmacological Mechanism of Trichosanthin, a Type 1 Ribosome-Inactivating Protein. [PDF]
Toxins (Basel), 2018 Trichosanthin (TCS) is an RNA N-glycosidase that depurinates adenine-4324 in the conserved α-sarcin/ricin loop (α-SRL) of rat 28 S ribosomal RNA (rRNA).
Shi WW, Wong KB, Shaw PC.
europepmc +2 more sources
Structures and Ribosomal Interaction of Ribosome-Inactivating Proteins [PDF]
Molecules, 2016 Ribosome-inactivating proteins (RIPs) including ricin, Shiga toxin, and trichosanthin, are RNA N-glycosidases that depurinate a specific adenine residue (A-4324 in rat 28S ribosomal RNA, rRNA) in the conserved α-sarcin/ricin loop (α-SRL) of rRNA.
Wei-Wei Shi +3 more
openaire +3 more sources
Molecular Plant-Microbe Interactions, 2001 The abundant maize kernel ribosome-inactivating protein 1 (RIP1) was tested for antifungal activity against Aspergillus nidulans and Aspergillus flavus.
Kirsten Nielsen +2 more
doaj +1 more source
Anti-Human Endoglin (hCD105) Immunotoxin-Containing Recombinant Single Chain Ribosome-Inactivating Protein Musarmin 1. [PDF]
Toxins (Basel), 2016 Endoglin (CD105) is an accessory component of the TGF-β receptor complex, which is expressed in a number of tissues and over-expressed in the endothelial cells of tumor neovasculature.
Barriuso B +7 more
europepmc +2 more sources
Microbial Cell, 2015 Apoptosis is an active form of programmed cell death (PCD) that plays critical roles in the development, differentiation and resistance to pathogens in multicellular organisms. Ribosome inactivating proteins (RIPs) are able to induce apoptotic cell death
Birsen Çakır, Nilgun E. Tumer
doaj +1 more source
Ribosome inactivating proteins and apoptosis
FEBS Letters, 2005 Ribosome inactivating proteins (RIPs) are protein toxins that are of plant or microbial origin that inhibit protein synthesis by inactivating ribosomes. Recent studies suggest that RIPs are also capable of inducing cell death by apoptosis. Though many reports are available on cell death induced by RIPs, the mechanism involved is not well studied ...
Narayanan, Sriram +4 more
openaire +2 more sources