Results 41 to 50 of about 26,838 (281)

Ribosome inactivating proteins and apoptosis

FEBS Letters, 2005
Ribosome inactivating proteins (RIPs) are protein toxins that are of plant or microbial origin that inhibit protein synthesis by inactivating ribosomes. Recent studies suggest that RIPs are also capable of inducing cell death by apoptosis. Though many reports are available on cell death induced by RIPs, the mechanism involved is not well studied ...
Narayanan, Sriram, Surendranath, Kalpana, Bora, Namrata, Surolia, Avadhesha, Karande, Anjali A   +4 more
openaire   +2 more sources

DeBouganin Diabody Fusion Protein Overcomes Drug Resistance to ADCs Comprised of Anti-Microtubule Agents

Molecules, 2016
Antibody drug conjugates (ADC), comprised of highly potent small molecule payloads chemically conjugated to a full-length antibody, represent a growing class of therapeutic agents.
Shilpa Chooniedass, Rachelle L. Dillon, Arjune Premsukh, Peter J. Hudson, Gregory P. Adams, Glen C. MacDonald, Jeannick Cizeau   +6 more
doaj   +1 more source

Viruses and the cellular RNA decay machinery. [PDF]

, 2010
The ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens.
Gaglia, Marta, Glaunsinger, Britt
core   +1 more source

Folding-competent and folding-defective forms of Ricin A chain have different fates following retrotranslocation from the endoplasmic reticulum [PDF]

, 2010
We report that a toxic polypeptide retaining the potential to refold upon dislocation from the endoplasmic reticulum (ER) to the cytosol (ricin A chain; RTA) and a misfolded version that cannot (termed RTAΔ), follow ER-associated degradation (ERAD ...
Shuyu Li, Robert A. Spooner, Stuart C. H. Allen, Christopher P. Guise, Graham Ladds, Tina Schnöder, Manfred J. Schmitt, J. Michael Lord, Lynne M. Roberts, Thomas Sommer, Alcock F., Allen S., Allen S. C., Argent R. H., Arndt V., Bar-Nun S., Barlowe C., Bazirgan O. A., Bellisola G., Biederer T., Bordallo J., Caldwell S. R., Carroll S. M., Carvalho P., Chaddock J. A., Christianson J. C., Deeks E. D., Denic V., Di Cola A., Duden R., Elkabetz Y., Endo Y., Gaber R. F., Gauss R., Ghislain M., Gietz R. D., Gillece P., Graham T. R., Haynes C. M., Hazes B., Heiligenstein S., Heinemeyer W., Hitt R., Jarosch E., Jarosch E., Kaiser C. A., Kawaguchi S., Kim I., Kim Y., Knop M., Kohler A., Lipson C., Lord J. M., Marshall R. S., Mayerhofer P. U., Medicherla B., Metzger M. B., Meusser B., Nakatsukasa K., Nishikawa S. I., Rabinovich E., Rodighiero C., Rouiller I., Rubin D. M., Sharma N., Sikorski R. S., Simpson J. C., Simpson J. C., Spear E. D., Spooner R. A., Spooner R. A., Spooner R. A., Springer S., Taxis C., Vashist S., Vashist S., Vogel J. P., Wesche J., Wilson J. D., Xia Z., Ye Y., Ye Y.   +81 more
core   +1 more source

Preparation of an antitumor and antivirus agent: chemical modification of α-MMC and MAP30 from Momordica Charantia L. with covalent conjugation of polyethyelene glycol [PDF]

, 2012
Background: Alpha-momorcharin (α-MMC) and momordica anti-HIV protein (MAP30) derived from Momordica charantia L. have been confirmed to possess antitumor and antivirus activities due to their RNA-N-glycosidase activity. However, strong immunogenicity and
Li, Juan, Liu, Shuangfeng, Meng, Yanfa, Meng, Yao, Zhao, Xiaojun   +4 more
core   +1 more source

Computational design of fusion proteins against ErbB2-amplified tumors inspired by ricin toxin

Frontiers in Molecular Biosciences, 2023
Although the anti-cancer activity of ricin is well-known, its non-specific targeting challenges the development of ricin-derived medicines. In the present study, novel potential ribosome-inactivating fusion proteins (RIPs) were computationally engineered
Yasser Ahmadi Moghaddam, Asad Maroufi, Sara Zareei, Mehdi Irani   +3 more
doaj   +1 more source

Ribosome‐inactivating proteins up to date

FEBS Letters, 1986
Ribosome‐inactivating proteins (RIPs) from plants inactivate eukaryotic ribosomes, as far as studied by rendering their 60 S subunit unable to bind elongation factor 2. These proteins seem widely distributed and possibly ubiquitous in plants. They are either type 1, those consisting of a single polypeptide chain, or type 2 (ricin and related toxins ...
Stirpe, Fiorenzo, Barbieri, Luigi
openaire   +2 more sources

Bioactive proteins and peptides isolated from Chinese medicines with pharmaceutical potential. [PDF]

, 2014
Some protein pharmaceuticals from Chinese medicine have been developed to treat cardiovascular diseases, genetic diseases, and cancer. Bioactive proteins with various pharmacological properties have been successfully isolated from animals such as Hirudo ...
CHEUNG, HP, Kwok, PCL, Lai, YM, Liu, WK, LU, J, Ng, TB, Shaw, PC, Sze, CW, Tong, Y, WONG, KL, Wong, RN, ZHANG, L, Zhang, Y, Zhang, Z   +13 more
core   +3 more sources

Functional Assays for Measuring the Catalytic Activity of Ribosome Inactivating Proteins

Toxins, 2018
Ribosome-inactivating proteins (RIPs) are potent toxins that inactivate ribosomes by catalytically removing a specific adenine from the α-sarcin/ricin loop (SRL) of the large rRNA.
Yijun Zhou, Xiao-Ping Li, Jennifer N. Kahn, Nilgun E. Tumer   +3 more
doaj   +1 more source

Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice

Toxins, 2015
All parts of dwarf elder (Sambucus ebulus L.) studied so far contain a ribosome-inactivating protein with lectin activity (ribosome-inactivating lectin; RIL), known as ebulin. Green fruits contain ebulin f, the toxicity of which has been studied in six-
Manuel Garrosa, Pilar Jiménez, Jesús Tejero, Patricia Cabrero, Damián Cordoba-Diaz, Emiliano J. Quinto, Manuel J. Gayoso, Tomás Girbés   +7 more
doaj   +1 more source