Results 61 to 70 of about 3,389,294 (250)

Structural studies of ribosome stalling and translocation complexes [PDF]

, 2010
In this study, cryo-electron microscopy (cryo-EM) and single particle reconstruction were used as a main technique to investigate the involvement of bacterial ribosomes in two crucial cellular processes: the regulation of gene expression and the ...
Seidelt, Birgit
core   +1 more source

Recombinant tritin protein exhibits antiviral activity against zucchini yellow mosaic virus

BMC Plant Biology
Background Ribosome-inactivating proteins (RIPs) are a group of proteins known to inhibit protein synthesis and contribute to plant defense responses. Although the antiviral properties of various RIPs have been demonstrated, the antiviral potential of ...
Serap Demi̇rel, Mustafa Usta, Gülüstan Korkmaz, Zeynelabidin Kurt   +3 more
doaj   +1 more source

Ribosome-inactivating Proteins from Phytolaccaceae

, 2014
The plant family Phytolaccaceae is a rich source of ribosome-inactivating proteins (RIPs), including the first characterized non-toxic type 1 RIP, pokeweed antiviral protein from the plant Phytolacca americana. The antiviral property is important because
DI MARO, Antimo, Angela Chambery, Parente A, Rosita Russo, Augusto Parente, Severino V., Valeria Severino, Antimo Di Maro, CHAMBERY, Angela, Russo R   +9 more
core   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Modification of ribosomal RNA by ribosome-inactivating proteins from plants [PDF]

Nucleic Acids Research, 1988
Footprinting experiments for DNase I digests of a 139-base-pair segment of pBR-322 DNA in the presence of either netropsin or actinomycin D were carried out. Plots of oligonucleotide concentration as a function of drug concentration were analyzed to study the enhancement in cleavage rates at approximately 30 sites, accompanying drug binding at other ...
Ward, Brian, Rehfuss, Robert, Goodisman, Jerry, Dabrowiak, James C   +3 more
openaire   +4 more sources

A Monoclonal–Monoclonal Antibody Based Capture ELISA for Abrin

Toxins, 2017
Abrin, one of the most highly potent toxins in the world, is derived from the plant, Abrus precatorius. Because of its high toxicity, it poses potential bioterror risks.
Christina C. Tam, Luisa W. Cheng, Xiaohua He, Paul Merrill, David Hodge, Larry H. Stanker   +5 more
doaj   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Engineering of Ribosome-inactivating Proteins for Improving Pharmacological Properties

Toxins, 2020
Ribosome-inactivating proteins (RIPs) are N-glycosidases, which depurinate a specific adenine residue in the conserved α-sarcin/ricin loop (α-SRL) of rRNA.
Jia-Qi Lu, Zhen-Ning Zhu, Yong-Tang Zheng, Pang-Chui Shaw   +3 more
doaj   +1 more source

Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation [PDF]

, 2007
A family of HEAT-repeat containing ribosome synthesis factors was previously identified in Saccharomyces cerevisiae. We report the detailed characterization of two of these factors, Utp10 and Utp20, which were initially identified as components of the ...
Tollervey, David, Dlakic, Mensur, Dez, Christophe   +2 more
core   +1 more source