Results 71 to 80 of about 25,873 (253)

Isolation and Molecular Characterization of Two Lectins from Dwarf Elder (Sambucus ebulus L.) Blossoms Related to the Sam n1 Allergen

Toxins, 2013
Sambucus species contain a number of lectins with and without antiribosomal activity. Here, we show that dwarf elder (Sambucus ebulus L.) blossoms express two D-galactose-binding lectins that were isolated and purified by affinity chromatography and gel ...
Tomas Girbes, Damian Cordoba-Diaz, José E. Basterrechea, Jesús Tejero, Patricia Cabrero, Pilar Jimenez   +5 more
doaj   +1 more source

Enzymatic Basis for the Oxidative Branch of Aromatic Amino Acid Fermentation Leading to p‐cresol Formation

Advanced Science, EarlyView.
In anaerobic bacteria, tyrosine serves as an electron donor in the oxidative Stickland fermentation branch, generating p‐hydroxyphenylacetate, ATP and reduced ferredoxin for decarboxylation into p‐cresol. ABSTRACT The phenolic metabolite p‐cresol is a byproduct of tyrosine fermentation by certain strictly anaerobic bacteria, including the human gut ...
Li Jiang, Yifeng Wei, Xumei Liu, Dazhi Liu, Zhenyu Liu, Yang Tong, Jinyu Yin, Ankanahalli N. Nanjaraj Urs, Meining Xing, Mark A. Harrison, Chuyuan Zhang, Sheng Yang, Yunzi Luo, Ee Lui Ang, Huimin Zhao, Yan Zhang   +15 more
wiley   +1 more source

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

Advanced Science, EarlyView.
Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan, Yelian Yan, Yalin Liang, Kanghua Zhong, Zhican Fu, Xiaobo Wang, Chao Liu, Tao Huang, Keliang Wu   +8 more
wiley   +1 more source

Burkholderia Lethal Factor 1, a Novel Anti-Cancer Toxin, Demonstrates Selective Cytotoxicity in MYCN-Amplified Neuroblastoma Cells

Toxins, 2018
Immunotoxins are being investigated as anti-cancer therapies and consist of a cytotoxic enzyme fused to a cancer targeting antibody. All currently used toxins function via the inhibition of protein synthesis, making them highly potent in both healthy and
Aleksander Rust, Sajid Shah, Guillaume M. Hautbergue, Bazbek Davletov   +3 more
doaj   +1 more source

Engineering of Ribosome-inactivating Proteins for Improving Pharmacological Properties

Toxins, 2020
Ribosome-inactivating proteins (RIPs) are N-glycosidases, which depurinate a specific adenine residue in the conserved α-sarcin/ricin loop (α-SRL) of rRNA.
Jia-Qi Lu, Zhen-Ning Zhu, Yong-Tang Zheng, Pang-Chui Shaw   +3 more
doaj   +1 more source

Modification of ribosomal RNA by ribosome-inactivating proteins from plants [PDF]

Nucleic Acids Research, 1988
We have surveyed 14 different toxic and nontoxic ribosome-inactivating proteins from plants for the ability to act on the RNA of the eucaryotic 60 S ribosomal subunit. All of these proteins act to introduce a specific modification into 26-28 S RNA which renders the RNA sensitive to cleavage by aniline.
F, Stirpe, S, Bailey, S P, Miller, J W, Bodley   +3 more
openaire   +3 more sources

A Dual‐Functional Biohybrid Nanorobot to Synergistically Eradicate Biofilm and Degrade Antibiotic Resistance Genes

Advanced Science, EarlyView.
A biohybrid nanorobot integrating lytic bacteriophage N4 with Pd nanozymes is developed for targeted eradication of multidrug‐resistant E. coli biofilms. Synergistic bacterial lysis and ROS‐mediated oxidation enable simultaneous biofilm removal and antibiotic resistance genes degradation, maintaining high efficacy in complex wastewater environments ...
Junzheng Zhang, Tong Dou, Luokai Wang, Jingxian Yang, Wenrui Wang, Shuaitian Guo, Xiangyu Li, Xuefang Huang, Yunlei Xianyu, Dongsheng Wang   +9 more
wiley   +1 more source

Folding-competent and folding-defective forms of Ricin A chain have different fates following retrotranslocation from the endoplasmic reticulum [PDF]

, 2010
We report that a toxic polypeptide retaining the potential to refold upon dislocation from the endoplasmic reticulum (ER) to the cytosol (ricin A chain; RTA) and a misfolded version that cannot (termed RTAΔ), follow ER-associated degradation (ERAD ...
Alcock F., Allen S., Allen S. C., Argent R. H., Arndt V., Bar-Nun S., Barlowe C., Bazirgan O. A., Bellisola G., Biederer T., Bordallo J., Caldwell S. R., Carroll S. M., Carvalho P., Chaddock J. A., Christianson J. C., Christopher P. Guise, Deeks E. D., Denic V., Di Cola A., Duden R., Elkabetz Y., Endo Y., Gaber R. F., Gauss R., Ghislain M., Gietz R. D., Gillece P., Graham Ladds, Graham T. R., Haynes C. M., Hazes B., Heiligenstein S., Heinemeyer W., Hitt R., J. Michael Lord, Jarosch E., Jarosch E., Kaiser C. A., Kawaguchi S., Kim I., Kim Y., Knop M., Kohler A., Lipson C., Lord J. M., Lynne M. Roberts, Manfred J. Schmitt, Marshall R. S., Mayerhofer P. U., Medicherla B., Metzger M. B., Meusser B., Nakatsukasa K., Nishikawa S. I., Rabinovich E., Robert A. Spooner, Rodighiero C., Rouiller I., Rubin D. M., Sharma N., Shuyu Li, Sikorski R. S., Simpson J. C., Simpson J. C., Spear E. D., Spooner R. A., Spooner R. A., Spooner R. A., Springer S., Stuart C. H. Allen, Taxis C., Thomas Sommer, Tina Schnöder, Vashist S., Vashist S., Vogel J. P., Wesche J., Wilson J. D., Xia Z., Ye Y., Ye Y.   +81 more
core   +2 more sources

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

Production of Recombinant Gelonin Using an Automated Liquid Chromatography System

Toxins, 2020
Advances in recombinant DNA technology have opened up new possibilities of exploiting toxic proteins for therapeutic purposes. Bringing forth these protein toxins from the bench to the bedside strongly depends on the availability of production methods ...
Maria E. B. Berstad, Lawrence H. Cheung, Anette Weyergang   +2 more
doaj   +1 more source