Antiviral Activity of PD-L1 and PD-L4, Type 1 Ribosome Inactivating Proteins from Leaves of Phytolacca dioica L. in the Pathosystem Phaseolus vulgaris-Tobacco Necrosis Virus (TNV). [PDF]
Toxins (Basel), 2020 Bulgari D +4 more
europepmc +1 more source
Ribosome-inactivating proteins: Entry into mammalian cells and intracellular routing
To catalytically-modify ribosomes in vivo, ribosome-inactivating proteins produced by plants must enter susceptible mammalian cells in order to reach their substrates in the cytosol.
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The Significance of cGAS‐STING Signaling in Response to Oncogenic Viruses
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT The cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) signaling pathway, as a key DNA sensor, plays a significant role in the regulation of innate immune responses. This pathway can be activated by sensing abnormal DNA, and is of great significance for resisting the invasion of pathogenic microorganisms and maintaining ...
Limei Guo +4 more
wiley +1 more source
The Molecular Architecture of Somatic Spines of the Lateral Septum
Journal of Comparative Neurology, Volume 534, Issue 9, September 2026.Spine synapses represent stable synaptic connections that allow neurons to chemically communicate with each other. Although known for decades, the unusual spine synapses found directly on neuronal cell bodies in the lateral septum have not been characterised in detail.
Daniela Hacker +6 more
wiley +1 more source
Genetics of ribosome-inactivating proteins
Ribosome-inactivating proteins (RIPs) are a heterogeneous group of enzymes found mainly in plants and a few bacteria that possess N-glycosidase activity on ribosomes and a related polynucleotide adenosine glycosidase activity on naked nucleic acids. They
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Developmental Dynamics, Volume 255, Issue 9, Page 896-914, September 2026.Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff +6 more
wiley +1 more source
Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics
MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.The challenges of mRNA therapy and the application of artificial intelligence and gene editing in the field of mRNA drugs. ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics.
Haixing Shi +11 more
wiley +1 more source
Ribosome-Inactivating Proteins from <i>Salsola soda</i> L. and <i>Saponaria officinalis</i> L. Are Promising Candidates for Targeted Therapy of Colon Cancer. [PDF]
BiomedicinesBiscotti F +8 more
europepmc +1 more source
MedComm, Volume 7, Issue 9, September 2026.Mitochondria is the hub of apoptosis in various diseases. The disruption of mitochondrial structure (including membrane rupture, cristae remodeling, and mitochondrial membrane lipid redistribution), the imbalance of mitochondrial dynamics (including fusion and fission, autophagy), the release, disruption, and mutation of mitochondria DNA, as well as ...
Rubin Tan +9 more
wiley +1 more source
Correction: Generality of toxins in defensive symbiosis: Ribosome-inactivating proteins and defense against parasitic wasps in Drosophila. [PDF]
PLoS PathogBallinger MJ, Perlman SJ.
europepmc +1 more source