Results 121 to 130 of about 25,229 (271)

A complex fruit‐specific type‐2 ribosome‐inactivating protein from elderberry (Sambucus nigra) is correctly processed and assembled in transgenic tobacco plants [PDF]

, 2002
Ying Chen, Frank Vandenbussche, Pierre Rougé, Paul Proost, Willy J. Peumans, Els J. M. Van Damme   +5 more
openalex   +1 more source

Leveraging paired germline and somatic analysis to improve the classification of DDX41 variants

British Journal of Haematology, EarlyView.
Summary Constitutional pathogenic variants in DDX41 predispose to myelodysplasia and acute myeloid leukaemia. Acquisition of subsequent somatic hits in the second allele is frequent, with notable recurrent variants at key hotspots. Sequencing of Deoxyribonucleic acid from blood/marrow of 239 patients with suspected/confirmed haematological malignancies
Andrew George, Elisabeth Rolf, Monika Domeradzka, Sara Ribeiro, Brittany Mills, April Hallett, Suzanne Macmahon, Paula Proszek, Ridwan Shaikh, Lina Yuan, Michael Hubank, Mikel Valganon Petrizan, Terri P. McVeigh, Jamshid S. Khorashad   +13 more
wiley   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Elimination of Ribosome Inactivating Factors Improves the Efficiency of Bacillus subtilis and Saccharomyces cerevisiae Cell-Free Translation Systems

Frontiers in Microbiology, 2018
Cell-free translation systems based on cellular lysates optimized for in vitro protein synthesis have multiple applications both in basic and applied science, ranging from studies of translational regulation to cell-free production of proteins and ...
Tetiana Brodiazhenko, Tetiana Brodiazhenko, Tetiana Brodiazhenko, Marcus J. O. Johansson, Hiraku Takada, Hiraku Takada, Tracy Nissan, Tracy Nissan, Vasili Hauryliuk, Vasili Hauryliuk, Vasili Hauryliuk, Victoriia Murina, Victoriia Murina   +12 more
doaj   +1 more source

The deoxyribonuclease activity attributed to ribosome‐inactivating proteins is due to contamination [PDF]

, 1998
Philip J. Day, Jonathan Lord, Lynne M. Roberts   +2 more
openalex   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

TM9SF2 Maintains Golgi Integrity and Regulates Ricin-Induced Cytotoxicity

Toxins
TM9SF2 belongs to a family of highly conserved nonaspanin proteins, and has been frequently identified as one of the important host factors for a plethora of lethal pathogens and toxins in previous genome-wide screening studies.
Yue Meng, Hongzhi Wan, Xinyu Wang, Lina Zhang, Ruozheng Xin, Lingyu Li, Yuhui Wang, Chengwang Xu, Hui Peng, Lu Sun, Bo Wang, Xiaotao Duan   +11 more
doaj   +1 more source

Isolation, Characterization and Biological Action of Type-1 Ribosome-Inactivating Proteins from Tissues of Salsola soda L. [PDF]

Toxins (Basel), 2022
Landi N, Ragucci S, Citores L, Clemente A, Hussain HZF, Iglesias R, Ferreras JM, Di Maro A.   +7 more
europepmc   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Bryodin, a ribosome-inactivating protein from the roots of Bryonia dioica L. (white bryony) [PDF]

, 1986
Fiorenzo Stirpe, L Barbieri, Maria Giulia Battelli, Anna Ida Falasca, Ada Abbondanza, E Lorenzoni, W. A. Stevens   +6 more
openalex   +1 more source