Results 101 to 110 of about 47,955 (276)

Ribosome profiling data from the model diatom Thalassiosira pseudonana Part 2

, 2023
Sequencing data from ribosome profiling run described in the protocol paper 'Ribosome profiling in the model diatom Thalassiosira pseudonana' HT_4: High temperature exposure (32°C) for 4 hours HT_24: High temperature exposure (32°C) for 24 ...
Claudia Buhigas (13842395), Markus Romberger (16303317), Annemarie Eckes-Shephard (11202435), Thomas Mock (14766161), Andreas Meindl (9747638), Gerhard Lehmann (4232911), Jan Medenbach (8518098), Monica Pichler (16501173), Sergio Llaneza-Lago (16303321), Amanda Hopes (3456923), Gunter Meister (47028), Carl-Fredrik Nyberg-Brodda (16303320)   +11 more
core   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Ribosome profiling in cyanobacteria

, 2018
Supplemental material for "Ribosome profiling of Synechocystis reveals altered ribosome allocation at carbon starvation" by Karlsen et al., 2018 (DOI: 10.1128/mSystems.00126-18).Legends.pdf contains the full legends, while short descriptions are shown ...
Johannes Asplund-Samuelsson (118185), Quentin Thomas (5483519), Michael Jahn (1790740), Paul Hudson (5483486), Jan Karlsen (5483516)   +4 more
core   +1 more source

Orthogonal Ionic Liquid‐Based Extraction Strategy Enables Amyloid‐Specific Profiling of Aggregate Proteome

Advanced Science, EarlyView.
An orthogonal ionic‐liquid extraction (Orth‐iEA) enables selective isolation of amyloid fibrils. TMGBF4 disrupts hydrogen‐bonded β‐sheet networks to solubilize amyloid aggregates, whereas C12ImCl interacts with hydrophobic regions of non‐amyloid proteins.
Shiying Zheng, Ye Liu, Bowen Zhong, Huiying Chu, Zhou Gong, Baofeng Zhao, Mengchun Cheng, Zhen Liang, Yukui Zhang, Qun Zhao, Lihua Zhang   +10 more
wiley   +1 more source

Ribosome signatures aid bacterial translation initiation site identification

BMC Biology, 2017
Background While methods for annotation of genes are increasingly reliable, the exact identification of translation initiation sites remains a challenging problem.
Adam Giess, Veronique Jonckheere, Elvis Ndah, Katarzyna Chyżyńska, Petra Van Damme, Eivind Valen   +5 more
doaj   +1 more source

Super-resolution ribosome profiling reveals unannotated translation events in Arabidopsis [PDF]

, 2016
Deep sequencing of ribosome footprints (ribosome profiling) maps and quantifies mRNA translation. Because ribosomes decode mRNA every 3 nt, the periodic property of ribosome footprints could be used to identify novel translated ORFs.
Ohler, U., Ohler, Uwe, Rothfels, Carl J, Calviello, Lorenzo, Wu, H.Y.L., Benfey, Philip N, Hsu, P.Y., Li, F.W., Calviello, L., Wu, Hsin-Yen Larry, Hsu, Polly Yingshan, Rothfels, C.J., Li, Fay-Wei, Benfey, P.N.   +13 more
core   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

sORFs.org : a repository of small ORFs identified by ribosome profiling [PDF]

, 2015
With the advent of ribosome profiling, a next generation sequencing technique providing a ‘snap-shot’ of translated mRNA in a cell, many short open reading frames (sORFs) with were identified.
Verheggen, Kenneth, Steven Verbruggen, Lennart Martens, Verbruggen, Steven, Menschaert, Gerben, Martens, Lennart, Volodimir Olexiouk, Olexiouk, Volodimir, Kenneth Verhegen, Crappé, Jeroen, Gerben Menschaert   +10 more
core   +1 more source

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

Advanced Science, EarlyView.
Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan, Yelian Yan, Yalin Liang, Kanghua Zhong, Zhican Fu, Xiaobo Wang, Chao Liu, Tao Huang, Keliang Wu   +8 more
wiley   +1 more source

Widespread Alterations in Translation Elongation in the Brain of Juvenile Fmr1 Knockout Mice

Cell Reports, 2019
Summary: FMRP (fragile X mental retardation protein) is a polysome-associated RNA-binding protein encoded by Fmr1 that is lost in fragile X syndrome. Increasing evidence suggests that FMRP regulates both translation initiation and elongation, but the ...
Sohani Das Sharma, Jordan B. Metz, Hongyu Li, Benjamin D. Hobson, Nicholas Hornstein, David Sulzer, Guomei Tang, Peter A. Sims   +7 more
doaj   +1 more source