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Exploring Ribosome Positioning on Translating Transcripts with Ribosome Profiling
2016Recent technological advances (e.g., microarrays and massively parallel sequencing) have facilitated genome-wide measurement of many aspects of gene regulation. Ribosome profiling is a high-throughput sequencing method used to measure gene expression at the level of translation.
Pieter, Spealman +4 more
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Choice of Ribonucleases for Ribosome Profiling Experiments
2021In the past 10 years, standard transcriptome sequencing protocols were optimized so well that no prior experience is required to prepare the sequencing library. Often, all enzymatic steps are designed to work in the same reaction tube minimizing handling time and reducing human errors. Ribosome profiling stands out from these methods.
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Analysis of codon-specific translation by ribosome profiling
2021Chemical modifications of RNA molecules can affect translation in multiple ways. Therefore, it is critical to understand how their absence changes cellular translation dynamics and in particular codon-specific translation. In this chapter, we discuss the application of ribosome profiling to analyze changes in codon-specific translation and differential
Yeji, Kim +5 more
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Codon Resolution Analysis of Ribosome Profiling Data
2021Translation is a central biological process in living cells. Ribosome profiling approach enables assessing translation on a global, cell-wide level. Extracting versatile information from the ribosome profiling data usually requires specialized expertise for handling the sequencing data that is not available to the broad community of experimentalists ...
Bartholomäus, A., Ignatova, Z.
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Ribosome Profiling for Novel Antigen Discovery
The identification of targetable antigens is crucial for advancing cancer immunotherapy. While traditional methods focus on tumor-associated antigens and somatic variants, recent advancements have highlighted novel antigen classes such as splice isoforms, gene fusions, ribonucleic acid (RNA) editing, and novel or unannotated open reading frames (nuORFs)Ana, Xavier-Magalhães, Susan, Klaeger
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Disome and Trisome Profiling Reveal Genome-Wide Targets of Ribosome Quality Control
Molecular Cell, 2020Nicholas R Guydosh, Sezen Meydan
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Ribosome Profiling Reveals the What, When, Where and How of Protein Synthesis
Nature Reviews Molecular Cell Biology, 2015Gloria A Brar, Jonathan Weissman
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