Results 111 to 120 of about 254,640 (401)
Advanced Engineering Materials, EarlyView.Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley +1 more source
How Cancer Exploits Ribosomal RNA Biogenesis: A Journey beyond the Boundaries of rRNA Transcription
Cells, 2019 The generation of new ribosomes is a coordinated process essential to sustain cell growth. As such, it is tightly regulated according to cell needs. As cancer cells require intense protein translation to ensure their enhanced growth rate, they exploit ...
Marco Gaviraghi +2 more
doaj +1 more source
Optimal Translation Along a Circular mRNA
, 2017 The ribosome flow model on a ring (RFMR) is a deterministic model for translation of a circularized mRNA. We derive a new spectral representation for the optimal steady-state production rate and the corresponding optimal steady-state ribosomal density in
Margaliot, Michael +2 more
core +2 more sources
Antibiotics and the ribosome [PDF]
Molecular Microbiology, 2006 SummaryThe ribosome is one of the main antibiotic targets in the cell. Recent years brought important insights into the mode of interaction of antibiotics with the ribosome and mechanisms of antibiotic action. Ribosome crystallography provided a detailed view of the interactions between antibiotics and rRNA.
Alexander S. Mankin, Tanel Tenson
openaire +3 more sources
Advanced Functional Materials, EarlyView.This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras +19 more
wiley +1 more source
The Arabidopsis cytosolic ribosomal proteome: from form to function
Frontiers in Plant Science, 2013 The cytosolic ribosomal proteome of Arabidopsis thaliana has been studied intensively by a range of proteomics approaches and is now one of the best-characterised eukaryotic ribosomal proteomes.
Adam James Carroll
doaj +1 more source
Role of the Mitochondrial Genome During Early Development in Mice [PDF]
, 1973 The role of the mitochondrial genome in early development and differentiation was studied in mouse embryos cultured in vitro from the two to four cell stage to the blastocyst (about 100 cells).
Chase, David G., Pikó, Lajos
core
Transport on a Lattice with Dynamical Defects [PDF]
, 2013 Many transport processes in nature take place on substrates, often considered as unidimensional lanes. These unidimensional substrates are typically non-static: affected by a fluctuating environment, they can undergo conformational changes.
Andrea Parmeggiani +7 more
core +6 more sources
Biotechnology Journal, 2012 AbstractSee accompanying article by Contreras‐Martin et al.
openaire +3 more sources
Impact of Nanoparticle Stiffness on Endosomal Escape and Signaling Pathways in Cytosolic Delivery
Advanced Healthcare Materials, EarlyView.Nanoparticle (NP) stiffness affects cellular uptake, but its impact on intracellular distribution remains unclear. This study synthesizes silica nanocapsules with varying stiffness, inspired by viral mechanisms, and applies assays to measure cellular uptake and escape efficiency.
Yali Zhang +6 more
wiley +1 more source