Differential stoichiometry among core ribosomal proteins [PDF]
Cell Reports 13: 865 - 873, 2015, 2014 Understanding the regulation and structure of ribosomes is essential to understanding protein synthesis and its deregulation in disease. While ribosomes are believed to have a fixed stoichiometry among their core ribosomal proteins (RPs), some ...
Airoldi, Edoardo +4 more
core +6 more sources
Incorporation in vivo of 14C-Labelled Amino Acids into the Proteins of Mitochondrial Ribosomes from Neurospora crassa Sensitive to Cycloheximide and Insensitive to Chloramphenicol [PDF]
, 1969 Radioactive amino acids were incorporated in vivo into Neurospora crassa cells, and the mitochondrial ribosomes were isolated. The incorporation of radioactivity into the proteins of these ribosomes was inhibited by cycloheximide, but not by ...
Bücher, Theodor +4 more
core +3 more sources
Gene length as a regulator for ribosome recruitment and protein synthesis : theoretical insights [PDF]
Scientific Reports 7, Article number: 17409 (2017), 2017 The authors would like to acknowledge the funding provided by the European Union Seventh Framework Programme [FP7/2007–2013] (NICHE; grant agreement 289384) (LDF).
Ciandrini, Luca +2 more
core +5 more sources
Ribosome recycling, diffusion, and mRNA loop formation in translational regulation [PDF]
Biophysical Journal, 85, 755-773, (2003), 2003 We explore and quantify the physical and biochemical mechanisms that may be relevant in the regulation of translation. After elongation and detachment from the 3' termination site of mRNA, parts of the ribosome machinery can diffuse back to the ...
Arfken +51 more
core +4 more sources
Stochastic kinetics of ribosomes: single motor properties and collective behavior [PDF]
Physical Review E, vol.80, 011908 (2009), 2009 Synthesis of protein molecules in a cell are carried out by ribosomes. A ribosome can be regarded as a molecular motor which utilizes the input chemical energy to move on a messenger RNA (mRNA) track that also serves as a template for the polymerization ...
A. S. Spirin +11 more
core +3 more sources
Adaptation of translational machinery in malaria parasites to accommodate translation of poly-adenosine stretches throughout its life cycle [PDF]
Frontiers in Microbiology, 2019 Malaria is caused by unicellular apicomplexan parasites of the ...
Djuranovic, Sergej +2 more
core +4 more sources
Ribosome collisions and Translation efficiency: Optimization by codon usage and mRNA destabilization [PDF]
J. Mol. Biol. 382, 236-245 (2008), 2008 Individual mRNAs are translated by multiple ribosomes that initiate translation with a few seconds interval. The ribosome speed is codon dependant, and ribosome queuing has been suggested to explain specific data for translation of some mRNAs in vivo. By
Mitarai, Namiko +2 more
core +2 more sources
Breaking the genetic code – a new revolutionary stage in the development of molecular biology: 1968 Nobel Prize laureates M. W. Nirenberg, H. G. Khorana, R. W. Holley [PDF]
The Ukrainian Biochemical Journal, 2021 This review presents the life stories of M. Nirenberg, H. Khorana, and R. Holley, winners of the 1968 Nobel Prize in Physiology or Medicine, the history of the discoveries made by these scientists, and the methodological approaches used in their works ...
O. P. Matyshevska +2 more
doaj +1 more source
Ribosome-omics of the human ribosome [PDF]
RNA, 2014 The torrent of RNA-seq data becoming available not only furnishes an overview of the entire transcriptome but also provides tools to focus on specific areas of interest. Our focus on the synthesis of ribosomes asked whether the abundance of mRNAs encoding ribosomal proteins (RPs) matched the equimolar need for the RPs in the assembly of ribosomes.
Jonathan R. Warner, Varun Gupta
openaire +3 more sources