Stochastic theory of protein synthesis and polysome: ribosome profile on a single mRNA transcript [PDF]
Journal of Theoretical Biology, vol.289, 36-46 (2011), 2011 The process of polymerizing a protein by a ribosome, using a messenger RNA (mRNA) as the corresponding template, is called {\it translation}. Ribosome may be regarded as a molecular motor for which the mRNA template serves also as the track. Often several ribosomes may translate the same (mRNA) simultaneously.
Agirrezabala +52 more
arxiv +3 more sources
Differential stoichiometry among core ribosomal proteins [PDF]
Cell Reports 13: 865 - 873, 2015, 2014 Understanding the regulation and structure of ribosomes is essential to understanding protein synthesis and its deregulation in disease. While ribosomes are believed to have a fixed stoichiometry among their core ribosomal proteins (RPs), some experiments suggest a more variable composition.
Airoldi, Edoardo +4 more
arxiv +8 more sources
Incorporation in vivo of 14C-Labelled Amino Acids into the Proteins of Mitochondrial Ribosomes from Neurospora crassa Sensitive to Cycloheximide and Insensitive to Chloramphenicol [PDF]
, 1969 Radioactive amino acids were incorporated in vivo into Neurospora crassa cells, and the mitochondrial ribosomes were isolated. The incorporation of radioactivity into the proteins of these ribosomes was inhibited by cycloheximide, but not by ...
Walter Neupert +4 more
openalex +4 more sources
Gene length as a regulator for ribosome recruitment and protein synthesis: theoretical insights [PDF]
Scientific Reports 7, Article number: 17409 (2017), 2017 Protein synthesis rates are determined, at the translational level, by properties of the transcript's sequence. The efficiency of an mRNA can be tuned by varying the ribosome binding sites controlling the recruitment of the ribosomes, or the codon usage establishing the speed of protein elongation. In this work we propose transcript length as a further
Ciandrini, Luca +2 more
arxiv +7 more sources
Ribosomal Proteins in Ribosome Assembly. [PDF]
BiomoleculesRibosomes are the cellular machinery responsible for translating mRNA into proteins, a process fundamental to all domains of life from bacteria to eukaryotes [...]
Pertschy B, Zierler I.
europepmc +3 more sources
Adaptation of Translational Machinery in Malaria Parasites to Accommodate Translation of Poly-Adenosine Stretches Throughout Its Life Cycle [PDF]
Frontiers in Microbiology, 2019 Malaria is caused by unicellular apicomplexan parasites of the genus Plasmodium, which includes the major human parasite Plasmodium falciparum. The complex cycle of the malaria parasite in both mosquito and human hosts has been studied extensively. There
Jessey Erath +2 more
doaj +3 more sources
Transcription-translation coupling: direct interactions of RNA polymerase with ribosomes and ribosomal subunits. [PDF]
Nucleic Acids Research, 2017 In prokaryotes, RNA polymerase and ribosomes can bind concurrently to the same RNA transcript, leading to the functional coupling of transcription and translation.
Blaha, Gregor M +9 more
core +2 more sources
Stochastic kinetics of ribosomes: single motor properties and collective behavior [PDF]
Physical Review E, vol.80, 011908 (2009), 2009 Synthesis of protein molecules in a cell are carried out by ribosomes. A ribosome can be regarded as a molecular motor which utilizes the input chemical energy to move on a messenger RNA (mRNA) track that also serves as a template for the polymerization of the corresponding protein.
A. S. Spirin +11 more
arxiv +5 more sources
Ribosome collisions and Translation efficiency: Optimization by codon usage and mRNA destabilization [PDF]
J. Mol. Biol. 382, 236-245 (2008), 2008 Individual mRNAs are translated by multiple ribosomes that initiate translation with a few seconds interval. The ribosome speed is codon dependant, and ribosome queuing has been suggested to explain specific data for translation of some mRNAs in vivo. By modelling the stochastic translation process as a traffic problem, we here analyze conditions and ...
Mitarai, Namiko +2 more
arxiv +3 more sources