Results 161 to 170 of about 558,329 (279)

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

La ricerca della felicità come felicità della ricerca

, 2012
Nell'odiema societa del rischio, suggestivamente definita da Beck, «globale, individualistica e piu morale di quanto si presuma», impemiata sull'etica «dell'autorealizzazione e delle conquiste individuali», ii dibattito sul "diritto alla ricerca della felicita", pone non pochi interrogativi e questioni del tutto inedite a cui non e semplice dare delle ...
openaire   +2 more sources

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Detection of <i>Hexametra angusticaecoides</i> (Nematoda: Ascarididae) in Italian bats: a squamate-associated nematode in mammals. [PDF]

Int J Parasitol Parasites Wildl
Fagundes-Moreira R, Mendoza-Roldan JA, Mori E, Ancillotto L, Vergari S, Dondini G, Chini C, Lia RP, Otranto D.   +8 more
europepmc   +1 more source

Rigid Hollow Microparticles for Enhanced Focused Ultrasound Treatment Under Optoacoustic Guidance

Advanced Science, EarlyView.
By combining focused ultrasound (FUS) and acoustically active hollow borosilicate microparticles (HBMPs), we demonstrate tunable control over interparticle dynamics and their localized thermal energy deposition. Modulation of acoustic frequency and particle concentration tailors the energy delivery, allowing adaptive, material‐based regulation of ...
Nima Mahkam, Yi Chen, Héctor Estrada, Ananya Amitabh, Amirreza Aghakhani, Metin Sitti, Daniel Razansky   +6 more
wiley   +1 more source

Deciphering the Causative Role of a Novel APC Gene Variant in Attenuated Familial Adenomatous Polyposis Using Germline DNA-RNA Paired Testing. [PDF]

Biomedicines
Forte G, Fasano C, Iacoviello M, Grossi V, Lepore Signorile M, De Marco K, Sanese P, Buonadonna AL, Manghisi A, Tutino NM, Disciglio V, Simone C.   +11 more
europepmc   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Tumour-infiltrating leucocytes as prognostic biomarkers of bevacizumab-treated ovarian cancer patients results from the phase IV MITO16A/MaNGO OV-2 clinical trial. [PDF]

NPJ Precis Oncol
Pivetta E, Canzonieri V, Bagnoli M, Chiodini P, Spina A, Arenare L, Lorusso D, Tasca G, Cecere SC, Ferrero A, Scognamiglio G, Basso-Valentina F, Califano D, De Cecco L, Di Lauro T, Nicoloso MS, Arcieri M, Russo D, Spessotto P, Indraccolo S, Mezzanzanica D, Perrone F, Pignata S, Baldassarre G.   +23 more
europepmc   +1 more source

Mapping Charge Interactions in Intrinsically Disordered Proteins

Advanced Science, EarlyView.
This study presents analytical models to predict intrachain distances in intrinsically disordered proteins (IDPs), accounting for charge patterning, salt concentration, and electrostatic effects. Validated against single‐molecule FRET data, a minimal‐parameter polymer model is identified that captures key interactions and chain dimensions. These models
Michael Phillips, Andrea Holla, Magdalena Wojtas, Aritra Chowdhury, Andrea Sottini, Sebastian L. B. König, Natalie Mutter, Nick Lamb, Jonathan Huihui, Monika Lopko, Andrea Soranno, Daniel Nettels, Andrzej Ożyhar, Benjamin Schuler, Kingshuk Ghosh   +14 more
wiley   +1 more source

Quantum reservoir computing for photonic entanglement witnessing. [PDF]

Sci Adv
Zia D, Innocenti L, Minati G, Lorenzo S, Suprano A, Di Bartolo R, Spagnolo N, Giordani T, Cimini V, Palma GM, Ferraro A, Sciarrino F, Paternostro M.   +12 more
europepmc   +1 more source