Results 181 to 190 of about 5,220,302 (284)

Chemical Synthesis and Functional Screening of an 800 000‐Member Library Using a Peptide‐Pairing Strategy

Angewandte Chemie, EarlyView.
Chemical peptide synthesis allows the generation of structurally highly diverse compounds suited for ligand development, but current methods in parallel peptide synthesis limit the achievable library size to a few thousand. A strategy is presented based on combinatorial pairing of short peptides via disulfide linkage that enables the generation and ...
Anne Zarda, Xingwang Deng, Edward Will, Thomas Emel, Maylin Romero, Christian Heinis   +5 more
wiley   +2 more sources

Combination of PARPi and topoisomerase I inhibitors is highly effective in olaparib-resistant ovarian cancer. [PDF]

Exp Hematol Oncol
Chiappa M, Villa V, Sias F, Grasselli C, Sala L, Canesi S, Marabese M, Mason S, Dibitetto D, Fruscio R, Damia G.   +10 more
europepmc   +1 more source

Engineering Ferrimagnetic Interactions in Molecular Quantum Systems

Angewandte Chemie, EarlyView.
Heterospin nanographene architectures—constructed by covalently linking spin‐1/2$\nicefrac {1}{2}$ and spin‐1 triangular units via on‐surface synthesis—are characterized by bond‐resolved scanning probe microscopy. Inelastic electron tunneling spectroscopy probes exchange interactions within a Heisenberg model, revealing both compensated (S=0$S=0$) and ...
Elia Turco, Fupeng Wu, Annika Bernhardt, Nils Krane, Ji Ma, Roman Fasel, Michal Juríček, Xinliang Feng, Pascal Ruffieux   +8 more
wiley   +2 more sources

Design and Characterization of Dual-Modal Fluorinated BODIPY Probes. [PDF]

Chempluschem
Ayaz N, Rosati M, Damoli M, Perez Rosas JC, Pizzi A, Metrangolo P, Orlandi S, Penconi M, Cavazzini M, Baldelli Bombelli F.   +9 more
europepmc   +1 more source

Light‐Driven Out‐of‐Equilibrium Helicity Control in a Diarylethene–Helicene Photosystem

Angewandte Chemie, EarlyView.
Distinct energy landscapes of different helicities in the open and closed states of a diarylethene–helicene photoswitch enable a light‐driven energy ratchet. Helix inversion occurs selectively in the closed form, and the resulting helicity is transferred and kinetically trapped upon ring opening, generating a persistent out‐of‐equilibrium chiral state ...
Eric Sidler, Jinghao Wang, Christina Vallina, Ben L. Feringa   +3 more
wiley   +2 more sources

Not Quite Folded: Challenges in Predicting the hNPS-hNPSR-Ile107 Complex With AlphaFold2 Multimer. [PDF]

ChemMedChem
Albanese V, Argentieri M, Agosta F, Rizzo A, Preti D, Reinscheid RK, Calò G, Guerrini R, Carotenuto A, Pacifico S, Ruzza C, Ciancetta A.   +11 more
europepmc   +1 more source

Neuropsychological Sub-Phenotypes in Amyotrophic Lateral Sclerosis. [PDF]

Eur J Neurol
Poletti B, Aiello EN, Consonni M, Iazzolino B, Torre S, Faltracco V, Telesca A, Palumbo F, Curti B, De Luca G, Moreschi A, Frisco F, Bella ED, Bersano E, Riva N, Verde F, Messina S, Doretti A, Maranzano A, Morelli C, Cappa SF, Calvo A, Strong MJ, Silani V, Lauria G, Chiò A, Ticozzi N.   +26 more
europepmc   +1 more source

Thouless quantum walks in topological flat bands. [PDF]

Light Sci Appl
Danieli C, Conti C, Pilozzi L, Brosco V.
europepmc   +1 more source

Efficacy of dual KRAS^G12D-EGFR blockade versus triple combinations in patient-derived models of KRAS^G12D-mutant colorectal cancer. [PDF]

Cell Death Dis
Leto SM, Sassi F, Zanella ER, Vurchio V, Cottino F, Ferri M, Damico A, Grassi E, Bertotti A, Trusolino L.   +9 more
europepmc   +1 more source

Beyond Radical Emitters: Hot‐Exciton Electroluminescence From Singlet Diradicaloids

Angewandte Chemie, EarlyView.
The first hot‐exciton mechanism in a singlet diradicaloid is demonstrated in a polychlorinated Thiele hydrocarbon‐based organic light‐emitting transistor. Reverse intersystem crossing involving the T2 and bright singly excited states enables electroluminescence beyond the 25% spin‐statistical limit, leading to remarkable external quantum efficiency ...
Mario Prosa, Eugenio Lunedei, Michele Orza, Davide Mesto, Roberto Cantoni, Francesco Reginato, Angela Punzi, Arthur R. J. Barreto, Yasi Dai, Benedetta Carlotti, Fabrizia Negri, Stefano Toffanin, Davide Blasi   +12 more
wiley   +1 more source