Inactivation of SAM-methyltransferase is the mechanism of attenuation of a historic louse borne typhus vaccine strain. [PDF]
Louse borne typhus (also called epidemic typhus) was one of man's major scourges, and epidemics of the disease can be reignited when social, economic, or political systems are disrupted.
Yan Liu +4 more
doaj +5 more sources
Background Among the 17 genes encoding autotransporter proteins of the "surface cell antigen" (sca) family in the currently sequenced Rickettsia genomes, ompA, sca5 (ompB) and sca4 (gene D), have been extensively used for identification and phylogenetic ...
Raoult Didier +3 more
doaj +2 more sources
Renewed Risk for Epidemic Typhus Related to War and Massive Population Displacement, Ukraine
Epidemic typhus, caused by Rickettsia prowazekii bacteria and transmitted through body lice (Pediculus humanus corporis), was a major public health threat in Eastern Europe as a consequence of World War II.
Paul N. Newton +3 more
doaj +1 more source
Transport of AMP by Rickettsia prowazekii [PDF]
Rickettsia prowazekii possesses an exchange transport system for AMP. Chromatographic analysis of the rickettsiae demonstrated that transported AMP appeared intracellularly as AMP, ADP, and ATP, and no hydrolytic products appeared in either the intracellular or extracellular compartments.
W H, Atkinson, H H, Winkler
openaire +2 more sources
Permeability of Rickettsia prowazekii to NAD [PDF]
Rickettsia prowazekii accumulated radioactivity from [adenine-2,8-3H]NAD but not from [nicotinamide-4-3H]NAD, which demonstrated that NAD was not taken up intact. Extracellular NAD was hydrolyzed by rickettsiae with the products of hydrolysis, nicotinamide mononucleotide and AMP, appearing in the incubation medium in a time- and temperature-dependent ...
W H, Atkinson, H H, Winkler
openaire +2 more sources
Genetic typing of isolates of Rickettsia typhi.
Murine typhus, which is caused by Rickettsia typhi, has a wide range of clinical manifestations. It has a low mortality rate but may result in meningoencephalitis and interstitial pneumonia in severe cases.
Cecilia Y Kato +4 more
doaj +1 more source
Infectious disease in the Pleistocene: Old friends or old foes?
Sources of evidence for studying infectious diseases of humans and other Pleistocene hominins. From top to bottom: DNA analysis of humans and hominins, modern and ancient, including the analysis of genomes at a population scale; palaeopathology, such as osteolytic skeletal lesions resulting from infection, and the study of mummified tissues or palaeo ...
Charlotte J. Houldcroft, Simon Underdown
wiley +1 more source
Detection and Genetic Diversity of Heritable Bacterial Symbionts in Human Lice Based on 16S-rRNA Gene. [PDF]
Candidatus Riesia pediculicola and Wolbachia were found in 79.6% and 95.2% of head lice, and 81.8% and 100% of body lice. Candidatus Riesia pthiripubis and Wolbachia appeared in 41.7% and 75% of pubic lice. Maximum‐likelihood 16S‐rRNA phylogeny revealed substantial heterogeneity within symbiont populations. ABSTRACT Human lice are obligate bloodsucking
Marteau A, Brun S, Izri A, Akhoundi M.
europepmc +2 more sources
Detection of Rickettsia spp. and Anaplasma ovis in Melophagus ovinus from southern Xinjiang, China
First report of the detection of Rickettsia massiliae DNA in M. ovinus. First report of the detection of Candidatus Rickettsia barbariae DNA in M. ovinus. Candidatus Rickettsia barbariae and Genotype III A. ovis can coexist in M. ovinus. Abstract Melophagus ovinus is a hematophagous insect that is distributed worldwide and plays a crucial role in ...
Si‐Ang Li +8 more
wiley +1 more source
Proline transport and metabolism in Rickettsia prowazekii [PDF]
Purified Rickettsia prowazekii cells were able to transport L-proline. The influx of this amino acid had a Kt of 14 microM and a Vmax of about 64 pmol/min per mg of protein. Proline could not be transported by heat-killed or metabolically poisoned rickettsiae or at 0 degrees C. The uptake of proline was linear for almost 2 h.
H H, Winkler, R M, Daugherty
openaire +2 more sources

