TRIM56-mediated production of type I interferon inhibits intracellular replication of Rickettsia rickettsii [PDF]
Rickettsia rickettsii (R. rickettsii), the causative agent of Rocky Mountain spotted fever (RMSF), is the most pathogenic member among Rickettsia spp.
Ruxi Cheng+10 more
doaj +4 more sources
Identification of an autotransporter peptidase of Rickettsia rickettsii responsible for maturation of surface exposed autotransporters. [PDF]
Members of the spotted fever group rickettsia express four large, surface-exposed autotransporters, at least one of which is a known virulence determinant.
Nock AM+10 more
europepmc +4 more sources
Experimental infection of dogs with a Brazilian strain of Rickettsia rickettsii: clinical and laboratory findings [PDF]
The bacterium Rickettsia rickettsii is the etiological agent of an acute, severe disease called Rocky Mountain spotted fever in the United States or Brazilian spotted fever (BSF) in Brazil.
Eliane M Piranda+6 more
doaj +6 more sources
The anal pore route is efficient to infect Amblyomma spp. ticks with Rickettsia rickettsii and allows the assessment of the role played by infection control targets [PDF]
Adult Amblyomma sculptum and Amblyomma aureolatum ticks are partially refractory to Rickettsia rickettsii when fed on infected hosts, hindering the functional characterization of potentially protective targets in the bacterial acquisition. In the current
Marcelly Bastos Nassar+5 more
doaj +3 more sources
The intracellular bacterium Rickettsia rickettsii exerts an inhibitory effect on the apoptosis of tick cells. [PDF]
Rickettsia rickettsii is a tick-borne obligate intracellular bacterium that causes Rocky Mountain spotted fever, a life-threatening illness. To obtain an insight into the vector–pathogen interactions, we assessed the effects of infection with R ...
Martins LA+12 more
europepmc +4 more sources
Core-genome guided novel therapeutic targets identification and chimeric vaccine designing against Rickettsia rickettsii. [PDF]
Rocky Mountain Spotted Fever, caused by the gram-negative intracellular bacteria Rickettsia rickettsii, is a serious tick-borne infection with a fatality rate of 20–30%, if not treated.
Arshad F+7 more
europepmc +3 more sources
Experimental infection of wild boars (Sus scrofa) with Rickettsia rickettsii and evaluation of the transmission potential to Amblyomma sculptum ticks [PDF]
Background Brazilian spotted fever is a tick-borne disease caused by the bacterium Rickettsia rickettsii, whose main vector in Brazil is the tick Amblyomma sculptum.
Lucianne Cardoso Neves+14 more
doaj +3 more sources
Development and validation of a novel detection method for Rickettsia rickettsii using a loop-mediated isothermal amplification assay. [PDF]
Introduction Rickettsia rickettsii is an obligate, intracellular pathogen and the causative agent of Rocky Mountain spotted fever (RMSF). RMSF is an important zoonotic disease due to its high fatal outcome in humans.
Carvajal-Gamez BI+7 more
europepmc +2 more sources
The Transcriptome of the Salivary Glands of Amblyomma aureolatum Reveals the Antimicrobial Peptide Microplusin as an Important Factor for the Tick Protection Against Rickettsia rickettsii Infection. [PDF]
The salivary glands (SG) of ixodid ticks play a pivotal role in blood feeding, producing both the cement and the saliva. The cement is an adhesive substance that helps the attachment of the tick to the host skin, while the saliva contains a rich mixture ...
Martins LA+9 more
europepmc +4 more sources
Susceptibility of Amblyomma sculptum, Vector of Rickettsia rickettsii, Ticks from a National Park and an Experimental Farm to Different Synthetic Acaricides. [PDF]
Amblyomma sculptum is a relevant tick species from a One Health perspective, playing an important role as a vector of Rickettsia rickettsii, the main agent of spotted fever rickettsiosis in Brazil. In this study, we evaluated the susceptibility of two A.
Cardoso ERN+17 more
europepmc +2 more sources