Nitric Oxide Inhibition of Rickettsia rickettsii. [PDF]
Rickettsia rickettsii , the causative agent of Rocky Mountain spotted fever, is an enzootic, obligate, intracellular bacterial pathogen. Nitric oxide (NO) synthesized by the inducible NO synthase (iNOS) is a potent antimicrobial component of innate immunity and has been implicated in the control of virulent ...
Fitzsimmons LF, Clark TR, Hackstadt T.
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Absorption of Rickettsia rickettsii antibodies by Rickettsia rickettsii antigens in four diagnostic tests [PDF]
Immunoabsorption profiles were determined for Rickettsia rickettsii antigens used in four confirmatory tests for detection of antibodies to Rocky Mountain spotted fever. A human serum reactive in the four tests was absorbed with each test antigen and then reexamined by all four tests.
K E, Hechemy +4 more
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Laboratory Maintenance of Rickettsia rickettsii [PDF]
AbstractThis unit includes protocols for the laboratory maintenance of the obligate intracellular bacterium Rickettsia rickettsii, including propagation in mammalian cell cultures, as well as isolation, counting, and storage procedures. Regulations for working with R. rickettsii in biosafety level 3 containment are also discussed. Curr.
Nicole C, Ammerman +2 more
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Selective fragmentation of the trans-Golgi apparatus by Rickettsia rickettsii. [PDF]
Fragmentation of the Golgi apparatus is observed during a number of physiological processes including mitosis and apoptosis, but also occurs in pathological states such as neurodegenerative diseases and some infectious diseases. Here we show that highly virulent strains of Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever ...
Aistleitner K +3 more
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Experimental infection of horses with Rickettsia rickettsii. [PDF]
Rickettsia rickettsii is vectored by ticks, and some vertebrate hosts can be sources of infection to ticks during bacteremic periods. In Brazil, the main vector for R. rickettsii is the tick Amblyomma sculptum, a member of the A. cajennense complex. Horses, in turn, are one of the major hosts for A. sculptum.
Ueno TE +5 more
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Rickettsia rickettsii and Rickettsia typhi in inhabitants from a rural community of southeast Mexico. [PDF]
Torres-Castro M +6 more
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Detection of fibrils associated with Rickettsia rickettsii [PDF]
The ultrastructural appearance of the "halozone" formed at the interface between the spotted fever agent Rickettsia rickettsii and the cytoplasm of persistently infected cultured vole cells (Microtus pennsylvanicus) was studied by transmission electron microscopy. In sections of epoxy-embedded specimens stained with uranyl acetate and lead citrate, the
W J, Todd, W, Burgdorfer, G P, Wray
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Seroepidemiological survey to investigate Rickettsia rickettsii and Rickettsia parkeri in municipalities of the southeast Brazil. [PDF]
ABSTRACT Spotted fever is a tick-borne rickettsiosis caused by several Rickettsia species—including R. rickettsii, R. parkeri, and others—with varying degrees of pathogenicity. Its nonspecific symptoms often lead to misdiagnosis such as dengue. This study investigated anti-R. rickettsii and R.
Franco MB +7 more
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Hosts mobility and spatial spread of Rickettsia rickettsii. [PDF]
There are a huge number of pathogens with multi-component transmission cycles, involving amplifier hosts, vectors or complex pathogen life cycles. These complex systems present challenges in terms of modeling and policy development. A lethal tick-borne infectious disease, the Brazilian Spotted Fever (BSF), is a relevant example of that.
Polo G +4 more
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In vitro susceptibilities of Rickettsia rickettsii and Rickettsia conorii to roxithromycin and pristinamycin [PDF]
In vitro susceptibilities of Rickettsia rickettsii and Rickettsia conorii to roxithromycin, pristinamycin, and the pristinamycin compounds, P1 and P2, were determined by a dye uptake assay and a plaque assay. The MICs were 1 microgram/ml for roxithromycin, 2 micrograms/ml for pristinamycin, greater than 256 micrograms/ml for P1, and 2 micrograms/ml for
M, Drancourt, D, Raoult
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