Results 21 to 30 of about 13,960 (198)

Autophagy facilitates intracellular survival of pathogenic rickettsiae in macrophages via evasion of autophagosomal maturation and reduction of microbicidal pro-inflammatory IL-1 cytokine responses

Microbiology Spectrum, 2023
The genus Rickettsia is comprised of obligate intracellular bacterial parasites of a wide range of arthropod and vertebrate hosts. Some Rickettsia species (spp.) are responsible for serious human diseases globally.
Oliver H. Voss, Hodalis Gaytan, Saif Ullah, Mohammad Sadik, Imran Moin, M. Sayeedur Rahman, Abdu F. Azad   +6 more
doaj   +1 more source

Significant Growth by Rickettsia Species within Human Macrophage-Like Cells Is a Phenotype Correlated with the Ability to Cause Disease in Mammals

Pathogens, 2021
Rickettsia are significant sources of tick-borne diseases in humans worldwide. In North America, two species in the spotted fever group of Rickettsia have been conclusively associated with disease of humans: Rickettsia rickettsii, the causative agent of ...
M. Nathan Kristof, Paige E. Allen, Lane D. Yutzy, Brandon Thibodaux, Christopher D. Paddock, Juan J. Martinez   +5 more
doaj   +1 more source

Absorption of Rickettsia rickettsii antibodies by Rickettsia rickettsii antigens in four diagnostic tests [PDF]

Journal of Clinical Microbiology, 1983
Immunoabsorption profiles were determined for Rickettsia rickettsii antigens used in four confirmatory tests for detection of antibodies to Rocky Mountain spotted fever. A human serum reactive in the four tests was absorbed with each test antigen and then reexamined by all four tests.
K E, Hechemy, R L, Anacker, N L, Carlo, J A, Fox, H A, Gaafar   +4 more
openaire   +2 more sources

Laboratory Maintenance of Rickettsia rickettsii [PDF]

Current Protocols in Microbiology, 2008
AbstractThis unit includes protocols for the laboratory maintenance of the obligate intracellular bacterium Rickettsia rickettsii, including propagation in mammalian cell cultures, as well as isolation, counting, and storage procedures. Regulations for working with R. rickettsii in biosafety level 3 containment are also discussed. Curr.
Nicole C, Ammerman, Magda, Beier-Sexton, Abdu F, Azad   +2 more
openaire   +2 more sources

Detection of fibrils associated with Rickettsia rickettsii [PDF]

Infection and Immunity, 1983
The ultrastructural appearance of the "halozone" formed at the interface between the spotted fever agent Rickettsia rickettsii and the cytoplasm of persistently infected cultured vole cells (Microtus pennsylvanicus) was studied by transmission electron microscopy. In sections of epoxy-embedded specimens stained with uranyl acetate and lead citrate, the
W J, Todd, W, Burgdorfer, G P, Wray
openaire   +2 more sources

Rickettsia rickettsii Co-feeding Transmission among Amblyomma aureolatum Ticks. [PDF]

Emerg Infect Dis, 2018
Amblyomma aureolatum ticks are vectors of Rickettsia rickettsii, the etiologic agent of Rocky Mountain spotted fever in Brazil. Maintenance of R. rickettsii in nature depends on horizontal transmission along tick generations.
Moraes-Filho J, Costa FB, Gerardi M, Soares HS, Labruna MB.   +4 more
europepmc   +2 more sources

Selective fragmentation of the trans-Golgi apparatus by Rickettsia rickettsii. [PDF]

PLoS Pathog, 2020
Fragmentation of the Golgi apparatus is observed during a number of physiological processes including mitosis and apoptosis, but also occurs in pathological states such as neurodegenerative diseases and some infectious diseases. Here we show that highly virulent strains of Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever ...
Aistleitner K, Clark T, Dooley C, Hackstadt T.   +3 more
europepmc   +5 more sources

In vitro susceptibilities of Rickettsia rickettsii and Rickettsia conorii to roxithromycin and pristinamycin [PDF]

Antimicrobial Agents and Chemotherapy, 1989
In vitro susceptibilities of Rickettsia rickettsii and Rickettsia conorii to roxithromycin, pristinamycin, and the pristinamycin compounds, P1 and P2, were determined by a dye uptake assay and a plaque assay. The MICs were 1 microgram/ml for roxithromycin, 2 micrograms/ml for pristinamycin, greater than 256 micrograms/ml for P1, and 2 micrograms/ml for
M, Drancourt, D, Raoult
openaire   +2 more sources

Application of reverse vaccinology for the identification of epitope candidates from Rickettsia rickettsii [PDF]

, 2020
643-647Rocky mountain spotted fever is a severe disease caused by Rickettsia rickettsii that frequently causes the death of the patients. As there are not effective vaccines for this disease, we employed reverse vaccinology to find epitope candidates ...
Lugo-Caballero, C, Rosado-Vallado, M, Dzul-Rosado, K, Arias-León, J, Peniche-Lara, G, Balam-Romero, B   +5 more
core   +5 more sources

Hosts mobility and spatial spread of Rickettsia rickettsii. [PDF]

PLoS Comput Biol, 2018
There are a huge number of pathogens with multi-component transmission cycles, involving amplifier hosts, vectors or complex pathogen life cycles. These complex systems present challenges in terms of modeling and policy development. A lethal tick-borne infectious disease, the Brazilian Spotted Fever (BSF), is a relevant example of that.
Polo G, Mera Acosta C, Labruna MB, Ferreira F, Brockmann D.   +4 more
europepmc   +6 more sources