Nitric Oxide Inhibition of Rickettsia rickettsii. [PDF]
Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever, is an enzootic, obligate, intracellular bacterial pathogen. Nitric oxide (NO) synthesized by the inducible NO synthase (iNOS) is a potent antimicrobial component of innate ...
Fitzsimmons LF, Clark TR, Hackstadt T.
europepmc +5 more sources
Selective fragmentation of the trans-Golgi apparatus by Rickettsia rickettsii. [PDF]
Fragmentation of the Golgi apparatus is observed during a number of physiological processes including mitosis and apoptosis, but also occurs in pathological states such as neurodegenerative diseases and some infectious diseases.
Aistleitner K+3 more
europepmc +7 more sources
Rickettsia rickettsii and Rickettsia typhi in inhabitants from a rural community of southeast Mexico. [PDF]
-
Torres-Castro M+6 more
europepmc +4 more sources
Hosts mobility and spatial spread of Rickettsia rickettsii. [PDF]
There are a huge number of pathogens with multi-component transmission cycles, involving amplifier hosts, vectors or complex pathogen life cycles. These complex systems present challenges in terms of modeling and policy development.
Polo G+4 more
europepmc +9 more sources
Comparative Susceptibility of Different Populations of Amblyomma sculptum to Rickettsia rickettsii. [PDF]
The bacterium Rickettsia rickettsii is the etiological agent of Brazilian spotted fever (BSF), which is transmitted in Brazil mainly by the tick Amblyomma sculptum. Herein, larvae and nymphs of six populations of A. sculptum were exposed to R. rickettsii
Gerardi M+5 more
europepmc +7 more sources
Transmission dynamics and control of Rickettsia rickettsii in populations of Hydrochoerus hydrochaeris and Amblyomma sculptum. [PDF]
Background Brazilian Spotted Fever (BSF), caused by the bacterium Rickettsia rickettsii, is the tick-borne disease that generates the largest number of human deaths in the world. In Brazil, the current increase of BSF human cases has been associated with
Polo G+3 more
europepmc +4 more sources
Immune Monitoring of Paediatric Patients Infected with Rickettsia rickettsii, Ehrlichia canis and Coinfected. [PDF]
In 2021, 273 Rocky Mountain spotted fever cases were reported nationwide in Mexico. In Chihuahua City, fourteen samples were obtained from children suspected of rickettsial infection.
Garcia-Rosales L+10 more
europepmc +2 more sources
Regulator of Actin-Based Motility (RoaM) Downregulates Actin Tail Formation by Rickettsia rickettsii and Is Negatively Selected in Mammalian Cell Culture. [PDF]
The mechanism of actin-based motility of spotted fever group Rickettsia has been studied extensively, but here, we provide genetic evidence that motility is a regulated process in R. rickettsii.
Nock AM, Clark TR, Hackstadt T.
europepmc +2 more sources
Isolation of Rickettsia rickettsii in Rocky Mountain Spotted Fever Outbreak, Panama. [PDF]
We report new cases of Rocky Mountain spotted fever in patients from Kinkantu, Ngäbe-Bugle indigenous comarca, Panama. We isolated Rickettsia rickettsii in cell culture after intraperitoneal inoculation of guinea pigs with tissues from a deceased patient.
Zaldívar Y+7 more
europepmc +2 more sources
Isolate-Dependent Differences in Clinical, Pathological, and Transcriptional Profiles following In Vitro and In Vivo Infections with Rickettsia rickettsii. [PDF]
Rickettsia rickettsii, the etiological agent of Rocky Mountain spotted fever (RMSF), a life-threatening tick-borne disease that affects humans and various animal species, has been recognized in medicine and science for more than 100 years.
Galletti MFBM+5 more
europepmc +2 more sources