Results 41 to 50 of about 197,250 (302)

The Riddle of Gravitation [PDF]

open access: yes, 2011
There is no doubt that both the special and general theories of relativity capture the imagination. The anti-intuitive properties of the special theory of relativity and its deep philosophical implications, the bizzare and dazzling predictions of the ...
Sid-Ahmed, A. M.
core  

Clinical Significance of Therapeutic Drug Level Monitoring for Mycophenolate in Patients With Extrarenal Systemic Lupus Erythematosus—A Systematic Review and Meta‐Analysis

open access: yesArthritis Care &Research, EarlyView.
Objective Clinical response to mycophenolic acid (MPA) is highly heterogeneous; thus, therapeutic drug level monitoring (TDM) may help improve treatment efficacy. This systematic review and meta‐analysis examined therapeutic ranges for MPA levels associated with better outcomes and safety in patients with systemic lupus erythematosus (SLE ...
Zahraa Qamhieh   +5 more
wiley   +1 more source

The riddle of the coronavirus

open access: yesNew Scientist, 2021
It is the many unknowns about covid-19 that make it so tricky to beat.
openaire   +2 more sources

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui   +14 more
wiley   +1 more source

Comparison of Two Distraction Methods on Venipuncture Pain in Children [PDF]

open access: yesMajallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2019
Background and Aim: Venipuncture is a common iatrogenic procedure and a great source of pain in children who attend to hospital. The aim of the present study was comparing the effect of playing a riddle and music on the severity of pain perception during
Tahminesadat Hoseini   +2 more
doaj  

Measuring CRM Aptitude: Is NOTECHS a Suitable Tool for Pilot Selection?

open access: yesInternational Journal of Aviation, Aeronautics, and Aerospace, 2016
Airline pilot’s primary job requirements have shifted from stick-and-rudder to CRM skills. At the same time, eliminating airline pilots from the job due to a lack of CRM skills is highly inefficient.
Hans-Joachim K. Ruff-Stahl   +6 more
doaj   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

open access: yesAdvanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang   +16 more
wiley   +1 more source

A Conceptual Model for a Universal Severity of Emergency Report (USER): An Example in Aviation

open access: yesInternational Journal of Aviation, Aeronautics, and Aerospace, 2017
In emergency situations, it is important that information be communicated quickly, concisely, and efficiently. Breakdowns can occur when the receiver of the emergency call does not fully understand the information that the person is sending.
Scott R. Winter   +5 more
doaj   +1 more source

Accuracy of vertical velocity determination [PDF]

open access: yes, 1983
Typical wind spectra taken at Poker Flat, Alaska, using the vertically oriented antenna show velocities of 10's of cm to meters per second and spectral widths winds of 0.5 to 1 m/s.
Riddle, A. C.
core   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

open access: yesAdvanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore   +20 more
wiley   +1 more source

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