Results 41 to 50 of about 16,551 (260)

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

open access: yesAdvanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian   +9 more
wiley   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

open access: yesAdvanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen   +8 more
wiley   +1 more source

A Conceptual Model for a Universal Severity of Emergency Report (USER): An Example in Aviation

open access: yesInternational Journal of Aviation, Aeronautics, and Aerospace, 2017
In emergency situations, it is important that information be communicated quickly, concisely, and efficiently. Breakdowns can occur when the receiver of the emergency call does not fully understand the information that the person is sending.
Scott R. Winter   +5 more
doaj   +1 more source

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

open access: yesAdvanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li   +7 more
wiley   +1 more source

Measuring CRM Aptitude: Is NOTECHS a Suitable Tool for Pilot Selection?

open access: yesInternational Journal of Aviation, Aeronautics, and Aerospace, 2016
Airline pilot’s primary job requirements have shifted from stick-and-rudder to CRM skills. At the same time, eliminating airline pilots from the job due to a lack of CRM skills is highly inefficient.
Hans-Joachim K. Ruff-Stahl   +6 more
doaj   +1 more source

Flat Bands Induced by Non‐Collinear Antiferromagnetism in CoBi2Te4

open access: yesAdvanced Science, EarlyView.
Flat bands emerge at the edges of intrinsically non‐collinear antiferromagnetic CoBi2Te4 two‐septuple layers through the interplay of spin–orbit coupling–driven band inversion and non‐collinear antiferromagnetism, uncovering a previously unexplored mechanism for flat‐band formation and opening new opportunities for strongly correlated quantum states ...
Ziyuan Zhao   +4 more
wiley   +1 more source

Not-So-Risky Business? Assessing the Risk of Integrating Large RPVs into the Current Air Traffic System

open access: yesInternational Journal of Aviation, Aeronautics, and Aerospace, 2016
In spite of considerable efforts to commercialize large remotely piloted vehicles (RPV), an integration of these RPVs into the existing Air Transportation System (ATS) and Airspace Structure is pending.
Hans-Joachim K. Ruff-Stahl   +6 more
doaj   +1 more source

The Riddle of Uveitis [PDF]

open access: yesPostgraduate Medical Journal, 1964
INFLAMMATION of the uveal tract, which comprises the iris, ciliary body and choroid, is the cause in 8.3% of cases of blindness in the fourth decade of life and in 2.5% of all cases of blindness in Britain (Sorsby 1956). In other words, about 2,500 of the 100,000 registered blind people in this country were blinded by uveitis and its complications, and
openaire   +2 more sources

Bioadhesive‐Integrated 3D‐Printed Multilayer Scaffolds Secure a Mechanically‐Stable Osteoimmune Niche for Enhanced Bone Augmentation

open access: yesAdvanced Science, EarlyView.
A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao   +7 more
wiley   +1 more source

Space Operations in the Suborbital Space Flight Simulator and Mission Control Center: Lessons Learned with XCOR Lynx

open access: yesJournal of Aviation/Aerospace Education & Research, 2018
This study was conducted to better understand the performance of the XCOR Lynx vehicle. Because the Lynx development was halted, the best knowledge of vehicle dynamics can only be found through simulator flights.
Pedro Llanos   +5 more
doaj   +1 more source

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