Results 11 to 20 of about 4,133,743 (170)

Applying machine learning and predictive modeling to retention and viral suppression in South African HIV treatment cohorts

Scientific Reports, 2022
HIV treatment programs face challenges in identifying patients at risk for loss-to-follow-up and uncontrolled viremia. We applied predictive machine learning algorithms to anonymised, patient-level HIV programmatic data from two districts in South Africa,
Mhairi Maskew, Kieran Sharpey-Schafer, Lucien De Voux, Thomas Crompton, Jacob Bor, Marcus Rennick, Admire Chirowodza, Jacqui Miot, Seithati Molefi, Chuka Onaga, Pappie Majuba, Ian Sanne, Pedro Pisa   +12 more
doaj   +1 more source

Predictive biomarkers and specific immune responses of COVID-19 mRNA vaccine in patients with cancer: prospective results from the CACOV-VAC trial

BMJ Oncology, 2023
Objective Vaccinated patients with cancer in follow-up studies showed a high seropositivity rate but impaired antibody titres and T cell responses following mRNA vaccine against COVID-19.
Laura Mansi, Olivier Adotevi, Marie Kroemer, Laurie Spehner, Adeline Bouard, Marine Jary, Romain Loyon, Christophe Borg, Dewi Vernerey, Syrine Abdeljaoued, Myriam Ben Khelil, Quentin Lepiller, Emeline Orillard, Antoine Falcoz, Hamadi Almotlak, Stefano Kim, Elsa Curtit, Guillaume Meynard, Charlee Nardin, Kamal Asgarov, Ugo Chartral, Virginie Mougey, Morgane Lopez   +22 more
doaj   +1 more source

Acute Myeloid Leukemia: From Biology to Clinical Practices Through Development and Pre-Clinical Therapeutics

Frontiers in Oncology, 2020
Recent studies have provided several insights into acute myeloid leukemia. Studies based on molecular biology have identified eight functional mutations involved in leukemogenesis, including driver and passenger mutations.
Xavier Roussel, Xavier Roussel, Etienne Daguindau, Etienne Daguindau, Ana Berceanu, Yohan Desbrosses, Walid Warda, Mathieu Neto da Rocha, Rim Trad, Eric Deconinck, Eric Deconinck, Marina Deschamps, Christophe Ferrand   +12 more
doaj   +1 more source

Epithelial to Mesenchymal Transition History: From Embryonic Development to Cancers

Biomolecules, 2021
Epithelial to mesenchymal transition (EMT) is a process that allows epithelial cells to progressively acquire a reversible mesenchymal phenotype. Here, we recount the main events in the history of EMT.
Camille Lachat, Paul Peixoto, Eric Hervouet   +2 more
doaj   +1 more source

Restoration of Five Digit Hand in Type III B & C Thumb Hypoplasia–A Game Changer in Surgical Management

Indian Journal of Plastic Surgery, 2020
Background Hypoplasia of thumb is the second common congenital difference of the thumb, next only to duplication. It may occur as an isolated hand difference or as a part of radial longitudinal deficiency.
G. Balakrishnan, S. Vijayaragavan, B. Somesh   +2 more
doaj   +1 more source

Changes in COVID-19 in-hospital mortality in hospitalised adults in England over the first seven months of the pandemic: An observational study using administrative data

The Lancet Regional Health. Europe, 2021
Summary: Background: Previous research by our team identified factors associated with in-hospital mortality in patients with a diagnosis of COVID-19 in England between March and May 2020. The aim of the current paper was to investigate the changing role
William K. Gray, Annakan V Navaratnam, Jamie Day, Julia Wendon, Tim W.R. Briggs   +4 more
doaj   +1 more source

Liver metastases of colorectal cancer contain different subsets of tissue-resident memory CD8 T cells correlated with a distinct risk of relapse following surgery

OncoImmunology
Tissue-resident memory (TRM) T cells have emerged as key players in cancer immunosurveillance, and their presence has been linked to a favorable clinical outcome in solid cancer patients.
Syrine Abdeljaoued, Alexandre Doussot, Marie Kroemer, Emilien Laloy, Jean René Pallandre, Antoine El Kaddissi, Laurie Spehner, Myriam Ben Khelil, Adeline Bouard, Virginie Mougey, Ugo Chartral, Angélique Vienot, Julien Viot, Zaher Lakkis, Franck Monnien, Romain Loyon, Christophe Borg   +16 more
doaj   +1 more source

Validation of a method evaluating T cell metabolic potential in compliance with ICH Q2 (R1)

Journal of Translational Medicine, 2021
Background Metabolic cell features are able to give reliable information on cell functional state. Thus, metabolic potential assessment of T cells in malignancy setting represents a promising area, especially in adoptive cell therapy procedures.
Patricia Mercier-Letondal, Chrystel Marton, Yann Godet, Jeanne Galaine   +3 more
doaj   +1 more source

Is Spheroid a Relevant Model to Address Fibrogenesis in Keloid Research?

Biomedicines, 2023
Keloid refers to a fibro-proliferative disorder characterized by an accumulation of extracellular matrix at the dermis level, overgrowing beyond the initial wound and forming tumor-like nodule areas. The absence of treatment for keloid is clearly related
Zélie Dirand, Marion Tissot, Brice Chatelain, Céline Viennet, Gwenaël Rolin   +4 more
doaj   +1 more source

Fomento de la Escritura Creativa y la Ciudadanía Global a través de la Literatura Anglochina Contemporánea en la Enseñanza Superior

Quaderns de Filologia: Estudis Literaris, 2023
En la actual era globalizada, la adquisición de la competencia intercultural se ha convertido en una herramienta de gran relevancia, ya que actualmente es más esencial que nunca fomentar las relaciones entre diferentes personas, culturas y naciones.
Mark H. Levine, Julia Hermosilla-León
doaj   +1 more source