Results 41 to 50 of about 16,739,290 (349)

Using antibiotics responsibly: right drug, right time, right dose, right duration [PDF]

Journal of Antimicrobial Chemotherapy, 2011
Everyone prescribing antibiotics should consider both their clinical and public health responsibilities. The objective should be to provide optimal patient care while at the same time seeking to minimize selective pressure that may result in the emergence and spread of antibiotic resistance.
Matthew, Dryden, Alan P, Johnson, Diane, Ashiru-Oredope, Mike, Sharland   +3 more
openaire   +2 more sources

Looking at silk [PDF]

, 1999
Text of Sir Robert Megarry’s speech at the Second Annual Lecture presented by the Society for Advanced Legal Studies, looking at the history and work of Queen’s Counsel.
Megarry, The Right Honourable Sir Robert
core  

Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis, Shauna R. Campbell, Jonathan Jang, Eashwar Somasundaram, Chandana A. Reddy, Jacob G. Scott, Lilyana Angelov, Peter M. Anderson, Matteo Trucco, Zachary Burke, Lukas Nystrom, Nathan Mesko, Anthony Magnelli, Erin S. Murphy   +13 more
wiley   +1 more source

Insulin restores renal neprilysin (NEP) and attenuates the shedding of urinary NEP and KIM-1 in diabetic Akita mice

Frontiers in Pharmacology
ObjectiveDiabetic kidney disease (DKD) is characterized by dysregulation of the renin-angiotensin system (RAS) and renal tubular injury. We investigated whether insulin treatment preserves renal homeostasis by modulating neprilysin (NEP), arginase-2 (Arg-
Rupinder K. Gill, Esam S. B. Salem, Nadja Grobe, Khalid M. Elased   +3 more
doaj   +1 more source

Symbrachydactyly

Indian Journal of Plastic Surgery, 2022
Symbrachydactyly is a rare congenital hand malformation in which a child is born with abnormally short digits that may be webbed, misshaped, or missing, and it is usually a unilateral condition.
Govindasamy Balakrishnan, S. Vijayaragavan, Balakrishnan Somesh   +2 more
doaj   +1 more source

Right here, right now: situated interventions to change consumer habits [PDF]

, 2017
Consumer behavior-change interventions have traditionally encouraged consumers to form conscious intentions, but in the past decade it has been shown that while these interventions have a medium-to-large effect in changing intentions, they have a much ...
Best, Maisy, Papies, Esther K.
core   +1 more source

Cerebrospinal Fluid Liquid Biopsy Enables Targeted Therapy Without Tissue Diagnosis in Pediatric Low‐Grade Gliomas With BRAF V600E Mutation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We present two pediatric cases of pediatric low‐grade gliomas (PLGG) with BRAF V600E mutations diagnosed and monitored using cerebrospinal fluid (CSF) liquid biopsy analyzed via digital droplet PCR (ddPCR), without tissue biopsy. Both patients were treated with dabrafenib and trametinib and monitored through clinical assessments, magnetic ...
Hannah Sultan, Damien Faury, Alexander G. Weil, Harrison J. Westwick, Nada Jabado, Sébastien Perreault   +5 more
wiley   +1 more source

Characterization of the aryl hydrocarbon receptor as a potential candidate to improve cancer T cell therapies

Cancer Immunology, Immunotherapy
The efficacy of T-cell-based cancer therapies can be limited by the tumor microenvironment which can lead to T cell dysfunction. Multiple studies, particularly in murine models, have demonstrated the capacity of the aryl hydrocarbon receptor (AHR) to ...
Valentine De Castro, Oumaïma Abdellaoui, Barbara Dehecq, Babacar Ndao, Patricia Mercier-Letondal, Alexandra Dauvé, Francine Garnache-Ottou, Olivier Adotévi, Romain Loyon, Yann Godet   +9 more
doaj   +1 more source

Chemoradiation triggers antitumor Th1 and tissue resident memory-polarized immune responses to improve immune checkpoint inhibitors therapy

Journal for ImmunoTherapy of Cancer, 2021
Background Multiple synergistic combination approaches with cancer drugs are developed to overcome primary resistance to immunotherapy; however, the mechanistic rationale to combine chemoradiotherapy (CRT) with immune checkpoint inhibitors remains ...
Florence Marliot, Marc Van den Eynde, Franck Pagès, Romain Boidot, Céline Mirjolet, Amos Kirilovsky, Carine El Sissy, Nacilla Haicheur-Adjouri, Viorel Scripcariu, Olivier Adotevi, Laurie Spehner, Elodie Lauret Marie Joseph, Benoît Lecoester, Laura Boullerot, Laurie Rangan, Amélie Marguier, Florent Tochet, Magalie Dosset, Jihane Boustani, Patrice Ravel, Jean-René Pallandre, Francis Bonnefoy, Emmanuel Cornillot   +22 more
doaj   +1 more source

Patient rights in precision oncology: right treatment, right time, right dose, right order, right place

Genome Medicine
Precision oncology has facilitated a transition from a one-size-fits-all to a precise individualized approach. This Comment discusses the broader challenges in the implementation of personalized treatments to further improve patients' outcomes, towards comprehensive strategies that address tumor complexity and patients' molecular portfolios, as well as
Elena Fountzilas, Apostolia-Maria Tsimberidou, Razelle Kurzrock   +2 more
openaire   +3 more sources